Rchr
J-GLOBAL ID：200901062346449725   Update date: Jan. 31, 2024

Takefumi Sone

ソネ タケフミ | Takefumi Sone
Affiliation and department：
Keio University

About Keio University


Job title： Project Assistant Professor / Project Research Associate / Project Instructor
Research field  (3)： Genetics ,  Molecular biology ,  Genomics
Research keywords  (3)： recombinase ,  Molecular cloning ,  genome editing
Research theme for competitive and other funds  (1)：
  • 2015 - 2017 Development of genome editing technology with low off-target risk and high efficiency in human pluripotent stem cells
Papers (36)：
  • Takefumi Sone, Masashi Shin, Takehito Ouchi, Hiroki Sasanuma, Arei Miyamoto, Satoshi Ohte, Sho Tsukamoto, Mahito Nakanishi, Hideyuki Okano, Takenobu Katagiri, et al. Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation. Scientific reports. 2019. 9. 1. 9705-9705
  • Tetsuya Akiyama, Naoki Suzuki, Mitsuru Ishikawa, Koki Fujimori, Takefumi Sone, Jiro Kawada, Ryo Funayama, Fumiyoshi Fujishima, Shio Mitsuzawa, Kensuke Ikeda, et al. Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons. EBioMedicine. 2019. 45. 362-378
  • Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita, Takefumi Sone, Moe Watanabe, Aya Maekawa, Takuya Matsumoto, Wado Akamatsu, Katsuhide Igarashi, et al. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain : a journal of neurology. 2019. 142. 6. 1675-1689
  • Sho Yoshimatsu, Junko Okahara, Takefumi Sone, Yuta Takeda, Mari Nakamura, Erika Sasaki, Noriyuki Kishi, Seiji Shiozawa, Hideyuki Okano. Robust and efficient knock-in in embryonic stem cells and early-stage embryos of the common marmoset using the CRISPR-Cas9 system. Scientific reports. 2019. 9. 1. 1528-1528
  • Tabata Y, Imaizumi Y, Sugawara M, Andoh-Noda T, Banno S, Chai M, Sone T, Yamazaki K, Ito M, Tsukahara K, et al. T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease. Stem cell reports. 2018. 11. 5. 1171-1184
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MISC (53)：
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Patents (5)：
  • 生細胞内の特定タンパク質の定量方法および標準蛍光マイクロビーズの作製方法
  • タンパク質溶液の調製方法、当該タンパク質溶液、当該タンパク質溶液を利用したモノクローナル抗体の作製方法及び当該モノクローナル抗体
  • 新規なバイオビーズの作製方法
  • 外来性遺伝物質又は生理活性物質を細胞内へ導入する新規な方法
  • Method For Introduction Of An Exogenous Genetic Substance Or A Physiologically Active Compound
Books (9)：
  • 2. Multigene assembly for construction of synthetic operons: Creation and delivery of an optimized all-in-one expression construct for generating mouse iPS cells. <I>In:</I> Primary and Stem Cells: Gene Transfer Technologies and Applications
    John Willey & Sons, Inc. Hoboken, NJ 2011 ISBN:9780470610749
  • 第2章 遺伝子クローニング 6. Gateway・Multisite Gatewayクローニング法. <I>In:</I> 「新遺伝子工学ハンドブック(改訂第5版)」実験医学別冊
    羊土社 東京 2010 ISBN:9784758101776
  • 8. 細胞への複数遺伝子の導入と発現量の制御 <I>In:</I> 「Gatewayを用いた遺伝子導入マニュアル」
    シュプリンガー・ジャパン株式会社 2009 ISBN:9784431100706
  • 21. Cell engineering using integrase and recombinase systems. <I>In:</I> Emerging Technology Platforms for Stem Cells
    John Willey & Sons, Inc. Hoboken, NJ 2009 ISBN:9780470146934
  • 第4章 組換えタンパク質の発現と精製のコツ 3. タンパク質発現系 -発現クローンの構築: Gateway®/MultiSite Gateway®法 <I>In:</I> 「タンパク質精製と取扱のコツ」実験医学別冊
    羊土社 東京 2007 ISBN:9784758101684
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Education (3)：
  • 1996 - 1999 Kyoto University Graduate School of Agriculture Division of Agricultural Chemistry
  • 1994 - 1996 Kyoto University Graduate School of Agriculture Division of Agricultural Chemistry
  • 1990 - 1994 Kyoto University Faculty of Agriculture Department of Agricultural Chemistry
Professional career (3)：
  • 博士(農学) (京都大学大学院)
  • 修士(農学) (京都大学大学院)
  • 学士(農学) (京都大学)
Work history (8)：
  • 2013/01/01 - Keio University Department of Physiology, School of Medicine Project Assistant Professor
  • 2011/01/01 - 2012/12/31 Saitama Medical University Research Center of Genomic Medicine Assistant Professor
  • 2007/04/01 - 2010/12/31 Osaka University Research Institute for Microbial Deseases Assistant Professor
  • 2004/04/01 - 2007/03/31 Osaka University Research Institute for Microbial Deseases Assistant Professor
  • 2001/12/01 - 2004/03/31 Osaka University Research Institute for Microbial Deseases Teacher
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Awards (1)：
  • 2003/09/16 - 日本生物工学会 日本生物工学会論文賞
Association Membership(s) (3)：
Japan Society for Bioscience, Biotechnology, and Agrochemistry ,  The Molecular Biology Society of Japan ,  The Japanese Society for Regenerative Medicine
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