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J-GLOBAL ID：200901068240732655 Update date: Oct. 11, 2024

Fujieda Nobutaka

フジエダノブタカ | Fujieda Nobutaka

Affiliation and department：
Job title： Professor

Research field (4)： Inorganic and coordination chemistry , Bioorganic chemistry , Molecular biochemistry , Biochemistry

Research keywords (7)： Biomolecular Technology , Bioinorganic Chemistry , Artificial Metalloenzyme , Chemomimetics , Biomimetics , Xenobiology , Artzyme

Research theme for competitive and other funds (31)：

2024 - 2027 金属中心のミクロ転位を誘起する人為酵素設計法の構築
2024 - 2026 カルコゲン含有補因子を自発形成する機能性タンパク質の創出
2023 - 2025 人工非ヘム金属酵素の分子設計と立体分岐型合成への応用
2023 - 2025 高選択的タングステン超集積バイオマテリアルの開発
2022 - 2024 立体分岐型合成を実現するタンパク質配位子ライブラリーの創出

2022 - 2024 Homeostasis of Early Transition Metals Regulated by Molybdenum Transport Protein

2021 - 2024 Rational design of artificial metalloenzymes using protein metal complexes

2021 - 2023 Creation of functional proteins bearing highly modified unusual protein-derived cofactors

2021 - 2022 Creation of Protein Ligand Library for Stereodivergent Synthesis

2021 - 2022 Development of Protein Ligand Library for Stereodivergent Synthesis

2020 - 2022 Homeostasis of Early Transition Metals Regulated by Molybdenum Storage Protein

2017 - 2021 革新的多機能性タグペプチドの開発

2019 - 2020 立体異性体の作り分けを実現するタンパク質配位子ライブラリーの開発

2018 - 2020 補因子組込型人工ラジカル金属酵素の合理的創出

2018 - 2020 タンパク質を多能性配位子とした精密制御反応場の創出

2016 - 2020 PRESTO

2018 - 2019 バイオ触媒を利用したガス状アルカンのアップグレーディング

2018 - 2019 黒髪形成と白皙を司るチロシナーゼの反応機構解明

2017 - 2019 化学進化を促進する原始金属酵素の探求

2017 - 2018 高立体選択的C-C結合反応を触媒する人工金属酵素の創製

2016 - 2018 タンパク質を機能性配位子とした精密制御反応場の創製

2016 - 2017 超安定な貴金属酵素を触媒とした高選択的酸化反応の開発

2016 - 2017 チロシナーゼと基質複合体結晶構造に基づいた反応機構の解明

2015 - 2017 新奇な補因子組込型人工ラジカル酵素の開発

2015 - 2017 化学進化を促進する古代金属タンパク質の構築

2010 - 2016 Creation of Transition-metal-Oxido Complexes for Direct C-H Bond Hydroxylation

2013 - 2015 Development of Novel Artificial Dinuclear Metalloenzymes and Application to Catalytic Oxidation Reactions

2012 - 2014 酸化的自己修飾を利用した高機能タンパク質の創製

2009 - 2011 潜在的酵素活性の制御による新規酵素の創製

2007 - 2008 三次元構造をもとにしたミニチュアメタン酸化酵素の創製

2005 - 2006 新しい原理に基づく電子移動型バイオセンサの基盤研究

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Papers (53)：

Nobutaka Fujieda, Atsuki Matsuo, Shinobu Itoh. Copper Complexes with Protein-Based N-Donor Ligands as cis-Selective Nascent Cyclopropanases. Chemistry - A European Journal. 2024
Yoshitsugu Morita, Hiroki Kubo, Ryusei Matsumoto, Nobutaka Fujieda. A thiopyridine-bound mirror-image copper center in an artificial non-heme metalloenzyme. Journal of Inorganic Biochemistry. 2024. 260. 112694-112694
Nobutaka Fujieda, Atsushi Tonomura, Tomofumi Mochizuki, Shinobu Itoh. Asymmetric Michael addition catalysed by copper-amyloid complexes. RSC Advances. 2024. 14. 1. 206-210
Ryusei Matsumoto, Saho Yoshioka, Miho Yuasa, Yoshitsugu Morita, Genji Kurisu, Nobutaka Fujieda. An Artificial Metallolyase with Pliable 2-His-1-Carboxylate Facial Triad for Stereoselective Michael Addition. Chemical Science. 2023
Yu SUGIMOTO, Nobutaka FUJIEDA, Kenji KANO. Electrochemical Consideration of Electrostatic Interaction of Charged Molecules with Partially Overlapped Electric Field: Zwitterions and Proteins. Electrochemistry. 2021

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MISC (23)：

藤枝伸宇. モリブデン中心を代替する生命金属. 生体の科学. 2024. 75. 2. 153-157
藤枝伸宇, 松本隆聖. 立体選択的反応を触媒する人工金属酵素のデザイン. バイオサイエンスとインダストリー. 2023. 81. 6. 520-521
藤枝伸宇, 伊東忍. チロシナーゼ反応機構における銅活性酸素種の動的挙動. 生化学. 2021. 93. 3. 521-525
Nobutaka Fujieda. His-Cys and Trp-Cys cross-links generated by post-translational chemical modification. Bioscience, Biotechnology, and Biochemistry. 2020. 84. 3. 445-454
藤枝伸宇. 非ヘム人工金属酵素の機能創製. 化学と工業. 2019. 72. 12. 1051-1052

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Patents (2)：

アルコールの製造方法
タンパク質によるタングステンの回収

Books (4)：

Encyclopedia of Catalysts and Catalysis
2023 ISBN:9784254252743
生命金属ダイナミクス ~生体内における金属の挙動と制御~
エヌ・ティー・エス 2021 ISBN:9784860437060
Assembly of Dinuclear Copper Center in Tyrosinase and Hemocyanins [Metalloprotein Active Site Assembly (Handbook of Metalloproteins to the Encyclopedia of Inorganic and Bioinorganic Chemistry)]
John Wiley & Sons, Ltd 2017
Fungal Pro-tyrosinase (Handbook of Metalloproteins to the Encyclopedia of Inorganic and Bioinorganic Chemistry)
John Wiley & Sons, Ltd: Chichester 2015

Lectures and oral presentations (20)：

Simple Designing Artificial Mononuclear Metalloenzymes that Catalyze Stereoselective Reactions
(RECONNECT Seminar 2024)
Simple Designing Artificial Non-heme Metalloenzymes that Catalyze Stereoselective Reactions
(Japan-Korea-Taiwan Bioinorganic Chemistry Symposium in Hokkaido 2024)
Toward Creation of Artificial Tungsten Hyperaccumulator
(The 3rd International Symposium on Biofunctional Chemistry (Satellite) 2024)
A Simple Method for Repurposing Cupin as Artificial Metalloenzymes that Catalyze Stereoselective Reactions
(IPR seminar “Enzymes & Photosynthesis - key for a green and sustainable future” 2024)
Artificial Metallolyases with Pliable Copper Center for Stereoselective Michael Addition
(Pre-ISBC2024 Symposium in Nara 2024)

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Education (1)：

2001 - 2006 Kyoto University Graduate School of Agriculture Division of Applied Life Sciences

Professional career (1)：

PhD (Kyoto University)

Work history (11)：

2022/04 - 現在 Osaka Metropolitan University Graduate School of Agriculture Professor
2013/04 - 現在 Osaka University Institute for Protein Research Research Fellow
2021/04 - 2022/03 Osaka Prefecture University Graduate School of Life and Environmental Sciences Professor
2017/04 - 2021/03 Osaka Prefecture University Graduate School of Life and Environmental Sciences Associate Professor
2016/10 - 2020/03 JST PRESTO Researcher

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Committee career (8)：

2024/04 - 現在金属の関与する生体関連反応シンポジウム評議員
2022/05 - 現在 Japan Society for Bioscience, Biotechnology, and Agrochemistry Delegate
2021/04 - 現在 The Kansai Branch of the Japan Society for Bioscience, Biotechnology, and Agrochemistry Consultant
2021/01 - 現在 ChemRxiv Scientific Advisory Board
2023/04 - 2025/03 Journal of Inorganic Biochemistry Guest editor (Special Issue on Artificial Metalloenzymes)

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Awards (8)：

2022/07 - ICCEOCA-15 Asian Core Program Lectureship Award (China)
2020/08 - 大阪府立大学 2020年度学長顕彰
2019/08 - 大阪府立大学 2019年度学長顕彰
2019/04 - 長瀬科学技術振興財団長瀬研究振興賞
2019/03 - 日本農芸化学会日本農芸化学奨励賞

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Association Membership(s) (5)：

The Society of Biological Inorganic Chemistry , 日本蛋白質科学会 , JAPAN SOCIETY OF COORDINATION CHEMISTRY , THE CHEMICAL SOCIETY OF JAPAN , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

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