Rchr

J-GLOBAL ID：200901072082312543 Update date: Aug. 21, 2024

Miyazaki Jun-ichi

ミヤザキジュンイチ | Miyazaki Jun-ichi

Affiliation and department：
Job title： Specially Appointed Professor

Research field (2)： Metabolism and endocrinology , Medical biochemistry

Research keywords (4)：遺伝子治療 , 糖尿病学 , 再生医学 , 発生工学

Research theme for competitive and other funds (86)：

2021 - 2024 Functional analysis of a novel membrane protein involved in the quality control of insulin in pancreatic beta cells
2013 - 2016 Analysis of a novel gene that affects the pluripotency of embryonic stem cells
2010 - 2012 Analysis of the transcriptional regulation of gametogenesis involving SOHLH proteins
2007 - 2008 The study of mechanism and treatment for the hyperammonemia in the glutamate dehydrogenase abnormality
2003 - 2005 骨髄幹細房誘導による人工血管感染の治療

2003 - 2005 Molecular characterization of congenital hyperinsulinism/hyperammonemia caused by glutamate dehydrogenase gene defects

2003 - 2005 Differentiation of ES cells to insulin-producing cells by expression of transcription factors

2003 - 2004 膵ベータ細胞における核内レセプターの機能の研究

2003 - 2004 Research on differentiation of endodermal cells from ES cells by introducing genes of transcription factor

2002 - 2004 Gene therapy for spinal code protection

2002 - 2004 Induction of insulin secreting cell and its application for transplantation

2001 - 2003 Development of islet regeneration therapy by stem cell biology

2001 - 2002 Improvement of muscle function by introducing genes by electroporation following intramuscular injection

2001 - 2002 The Identification of Cardioprotective Mechanism Afforded by Ischemic Preconditioning and its Application to the Therapy Against Acute Myocardial Infarction

2000 - 2002 Molecular characterization of congenital hyperinsulinism/hyperammonemia caused by glutamate dehydrogenase gene defects

2000 - 2002 Diabetes as a Model for Functional Genomics in Multifactorial Diseases

2000 - 2002 Study on prevention of fetal abnormalities by maternal diabetes mellitus using transgenic mice overexpressing thioredoxin

2000 - 2002 バイオ人工膵による移植治療システムの開発

2000 - 2001 多因子疾患糖尿病における機能ゲノム学の新展開

2000 - 2001 Construction of adenovirus vectors using of Cre-loxPrecombination system

2000 - 2001 Acquirement of the Ischemic Cardioprotection and ecto-5'-nucleotidase : Investigation of the Receptor Activation and Subsequent Signal Transduction

1999 - 2001 Novel Therapy for Heart Failure of cardiomyopathic Hamster with Gene Transfection of Hepatocyte Growth Factor

1999 - 2001 ESTABLISHMENT OF FEEDER- AND SERUM-FREE CULTURE SYSTEM OF ES CELLS AND ITS APPLICATION TO PROPAGATE ES CELLS FROM INBRED MICE EMBRYOS

2000 - 2000 新しい血管新生因子受容体ncuropilin familyと血管神経相互作用

2000 - 2000 Oct-3/4による初期分化決定機構の解析

1998 - 2000 Xenogenic islet transplantation system based on tissue engineering

1999 - 1999 Oct-3/4による初期分化決定機構の解析

1999 - 1999 免疫病とその修復

1998 - 1999 Molcular Mechanisms and Clinical Role of the Phosphorylation and Activation of Ecto-5'-Nucleotidase, Adenosine Producing Enzyme in Cardioprotection.

1998 - 1999 Development and Establishment of a New Therapeutic Strategy for Chronic Heart Failure due to Adenosine.

1998 - 1999 Redundancy and specified function of the serine protease inhibitors, SLPI and elafin, in the airway tracts

1997 - 1998 Immunological analyses and gene therapy in chronic colitis of IL-12p40 transgenic mice

1996 - 1998 Development of insulin secreting B cell line for Diabetes Mellitus by transgenic pigs

1996 - 1998 DEVELOPMENT OF A NOVEL STRATEGY FOR GENETIC ANALYSIS OF MULTIFACTORIAL TRAITS USING DIABETES AS A MODEL CASE

1995 - 1998 Molecular mechanism of synaptic plasticity

1997 - 1997 発生工学を用いた膵島移植における免疫拒絶反応制御の研究

1996 - 1996 筋肉内直接遺伝子導入法によるI型糖尿病の予防的遺伝子治療の基礎的研究

1996 - 1996 I型糖尿病モデルマウスの膵島浸潤Tリンパ球のクローナリティーの解析

1996 - 1996 トランスジェニックマウスを用いた自己免疫性糖尿病発症機構の解析

1996 - 1996 マウス発生工学を用いた核内レセプターRXRの機能解析

1995 - 1996 DEVELOPMENT OF BIOARTIFICIAL ENDOCRINE PANCREAS USING GLUCOSE-RESPONSIVE B-CELL LINE MIN6

1995 - 1996 Xenogeneic Tnukplantation of Islets Employing Bioartificial Pancreas

1995 - 1995 インスリン分泌制御におけるPI3キナーゼの役割の解析

1995 - 1995 マウス発生工学を用いた核内レセプターRXRの機能解析

1995 - 1995 胚幹細胞への欠失変異導入法の開発

1995 - 1995 トランスジェニックマウスを用いたI型糖尿病発症機構の解析

1995 - 1995 免疫担当細胞の活性化と発癌抑制の研究

1994 - 1995 Molecular Biology of B-Cells of Pancreatic Islets of Langerhans : Basic Study to develop Gene Therapy for Diabetes

1994 - 1994 グルコース反応性β細胞株MIN6を用いたグルコースセンシング機構の解析

1994 - 1994 マウス発生工学を用いた核内レセプターRXRの機能解析

1994 - 1994 胚幹細胞への欠失変異導入法の開発

1994 - 1994 トランスジェニックマウスを用いたI型糖尿病発症機構の解析

1993 - 1994 遺伝子導入法を用いた疾患モデルマウスの作出しと疾患制御機構に関する研究

1993 - 1994 Analysis of Immunological Destruction Mechanism of Pancreatic Islet B Cells Using a Transgenic Mouse Model

1992 - 1994 Development of Gene Therapy for Type I Diabetes Using Cytokine Gene and Pancreatic Islet B Cell-Specific Lymphocytes

1993 - 1993 胚幹細胞への欠失変異導入法の開発

1993 - 1993 MHCトランスジェニックマウスを用いたI型糖尿病発症機構の解析

1993 - 1993 MODY型糖尿病のモデルマウス作製による発症機構の解析

1993 - 1993 癌浸潤モデルとしてのトロフォブラストの研究

1993 - 1993 免疫系担当細胞の発生・分化に関与するリンホカイン及びその受容体の解析

1992 - 1992 NODマウスのI型糖尿病発症に関与するMHCクラスII・I-Aβ鎖の解析

1992 - 1992 発生異常の分子機構のジーントラッピング法による解析

1992 - 1992 癌浸潤モデルとしてのトロフォブラストの研究

1992 - 1992 リンパ系幹細胞とストローマ細胞間の相互作用に関する研究

1991 - 1992 Study on the relationship between expression of islet amyloid polypeptide and onset of type 2 diabetes mellitus.

1991 - 1992 Molecular Analysis of a Glucose-concentration sensing system which Regulates Insulin Gene Expression

1991 - 1991 トランスジェニックNODマウスを用いたI型糖尿病に関与するMHC遺伝子の解析

1991 - 1991 NODマウスにおける膵島β細胞腫瘍の誘導とその解析

1991 - 1991 リンパ系幹細胞とストロ-マ細胞間の相互作用に関する研究

1989 - 1991 Analysis on the molecular mechanism of development using insertional mutant mice.

1990 - 1990 主要組織適合クラス工抗原の胎生期発現とそのマウス胎児母体関係への影響

1990 - 1990 NODマウスにおける膵島β細胞腫瘍の誘導とその解析

1989 - 1989 主要組織適合クラスI抗原の胎生期発現とそのマウス胎児-母体関係への影響

1989 - 1989 Transgenic mouseを用いた発癌の組織特異性に関する研究

1988 - 1989 Molecular genetic analysis of familial amyloidotic polyneuropathy

1988 - 1988 Transgenic mouseを用いた発癌の組織特異性に関する研究

1987 - 1987 Transgenic mouseを用いた発癌の組織特異性に関する研究

1986 - 1987 Production of a transgenic mouse model of familial amyloidotic polyneuropathy.

Application of stem cells to cell replacement therapy for diabetes

Study on in vitro differentiation of ES cells

Study on human diseases using knock-out mice

Study on human diseases using transgenic mice

幹細胞からのインスリン産生細胞の作製法

ES細胞の試験管内分化の研究

ノックアウトマウスを用いた疾患研究

トランスジェニックマウスを用いた疾患研究

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Papers (460)：

Satsuki Miyazaki, Hiroyuki Yamano, Daisuke Motooka, Fumi Tashiro, Takumi Matsuura, Tatsushi Miyazaki, Jun-Ichi Miyazaki. Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells. Communications biology. 2023. 6. 1. 771-771
Yasuki Nagai, Taka-Aki Matsuoka, Naoki Shimo, Takeshi Miyatsuka, Satsuki Miyazaki, Fumi Tashiro, Jun-Ichi Miyazaki, Naoto Katakami, Iichiro Shimomura. Glucotoxicity-induced suppression of Cox6a2 expression provokes β-cell dysfunction via augmented ROS production. Biochemical and biophysical research communications. 2021. 556. 134-141
Keitaro Yoshioka, Haruki Yamashita, Kazunori Shimizu, Sayako Shimomura, Takahiro Shibata, Jun-Ichi Miyazaki, Hiroyuki Honda. Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution. Biochemical and biophysical research communications. 2021. 550. 177-183
Satsuki Miyazaki, Fumi Tashiro, Takashi Tsuchiya, Kazuki Sasaki, Jun-Ichi Miyazaki. Establishment of a long-term stable β-cell line and its application to analyze the effect of Gcg expression on insulin secretion. Scientific reports. 2021. 11. 1. 477
Katsuhide Okunishi, Hao Wang, Maho Suzukawa, Ray Ishizaki, Eri Kobayashi, Miho Kihara, Takaya Abe, Jun-Ichi Miyazaki, Masafumi Horie, Akira Saito, et al. Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses. The Journal of clinical investigation. 2020. 130. 7. 3919-3935

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MISC (744)：

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Patents (19)：

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Books (23)：

プログレッシブ生命科学
南山堂 2014
遺伝子導入プロトコール
2012
再生医療叢書第5巻代謝系臓器
朝倉書店 2012
糖尿病ナビゲーター第2版
メディカルレビュー社 2010
2型糖尿病における膵β細胞研究の進歩
2008

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Works (2)：

Improved method for adenovirus vector production
2000 -
高効率アデノウイルスベクター作製法の開発
2000 -

Education (4)：

1979 - 1983 Osaka University Faculty of Medicine Medical School
1975 - 1978 Kyoto University Graduate School of Science
1973 - 1975 Kyoto University Graduate School of Science
1969 - 1973 Kyoto University Faculty of Science

Professional career (1)：

Ph.D. (Kyoto University)

Work history (8)：

2020/04 - 現在 Osaka University The Institute of Scientific and Industrial Research
2016/04 - 2020/03 Osaka University
1996/09 - 2016/03 Osaka University Graduate School of Medicine Professor
1994/03 - 1997/03 Tohoku University Professor
1991/04 - 1996/03 The University of Tokyo Faculty of Medicine

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Committee career (3)：

2003 - 日本炎症・再生医学会評議員
2001 - 日本再生医療学会評議員
日本糖尿病学会功労学術評議員

Association Membership(s) (4)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本炎症・再生医学会 , 日本再生医療学会 , 日本糖尿病学会

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