Yasuhiko Yukuto

ヤスヒコユクト | Yasuhiko Yukuto

Affiliation and department：
Job title： Senior researcher

Research field (1)： Developmental biology

Research keywords (5)： Reproductive and Developmental Toxicity , トランスジェニック動物 , 遺伝子ノックアウト , 発現制御 , 発生工学

Research theme for competitive and other funds (6)：

2015 - 2018 ヒトiPSおよび新規遺伝子改変マウスを用いたネフローゼ症候群の病因解明
2011 - 2013 Analysis of relationship between somite segmentation and vertebra segmentation
2008 - 2010 Functional difference between Notch ligands Dll1 and Dll3 in mouse somitogenesis
2005 - 2009 The mechanism of somite segmentation with periodic patterning
2005 - 2006 Molecular genetic analysis of relationship between traveling wave and constant wave of molecular clock in somitogenesis

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Papers (24)：

Shigeru Yamada, Tadahiro Hashita, Shota Yanagida, Hiroyuki Sato, Yukuto Yasuhiko, Kaori Okabe, Takamasa Noda, Motohiro Nishida, Tamihide Matsunaga, Yasunari Kanda. SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway. Fluids and barriers of the CNS. 2024. 21. 1. 32-32
Yukuto Yasuhiko, Miwa Ishigami, Satoshi Machino, Tatsuya Fujii, Masanori Aoki, Fumi Irie, Yasunari Kanda, Midori Yoshida. Comparison of the lower limit of benchmark dose confidence interval with no-observed-adverse-effect level by applying four different software for tumorigenicity testing of pesticides in Japan. Regulatory toxicology and pharmacology : RTP. 2022. 133. 105201-105201
Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko, Yasunari Kanda. Transforming Growth Factor Beta Promotes the Expansion of Cancer Stem Cells <i>via</i> S1PR3 by Ligand-Independent Notch Activation. Biological and Pharmaceutical Bulletin. 2022. 45. 5. 649-658
Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko, Motohiro Nishida, Yasunari Kanda. Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer. International journal of molecular sciences. 2022. 23. 4. 1967-1967
Yusuke Okubo, Fumiaki Ohtake, Katsuhide Igarashi, Yukuto Yasuhiko, Yoko Hirabayashi, Yumiko Saga, Jun Kanno. Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal dependent and independent pathways. Development (Cambridge, England). 2021

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MISC (10)：

Toshime Igarashi, Yukuto Yasuhiko, Ryuichi Ono, Yu Takahashi, Makiko Kuwagata, Satoshi Kitajima. Diverse on-target mutations in the genome-edited mice and their transmission to the next generation. Experimental Animals. 2024. 73. Supplement. S126-S126
Toshime Igarashi, Yukuto Yasuhiko, Ryuichi Ono, Erika Tachihara, Miki Uchiyama, Atsuya Takagi, Yu Takahashi, Makiko Kuwagata, Satoshi Kitajima. Germline-transmission in the knock-in mice of N0 generation with diverse and unintended on-target mutations induced by CRISPR/Cas9-mediated genome editing. 2021. 46. Supplement. P-91
Toshime Igarashi, Yukuto Yasuhiko, Ryuichi Ono, Erika Tachihara, Yu Takahashi, Makiko Kuwagata, Satoshi Kitajima. CRISPR/Cas9-mediated genome editing of mouse zygotes induces diverse on-target unintentional mutations. Journal of Toxicological Sciences. 2020. 45. Supplement. P-180
K. Takeda, I. Kou, N. Kawakami, Y. Yasuhiko, Y. Ogura, E. Imagawa, N. Miyake, N. Matsumoto, H. Sudo, T. Kotani, et al. Expanding the phenotype of DNAJC3 mutations: A case with hypothyroidism additionally to diabetes mellitus and multisystemic neurodegeneration Response. CLINICAL GENETICS. 2017. 92. 5. 563-564
Yukuto Yasuhiko, Yoko Hirabayashi, Ryuichi Ono. Tbx6 regulates gene expression via binding sites in Long Terminal Repeats (LTR) of endogenous retrovirus during mouse embryogenesis. MECHANISMS OF DEVELOPMENT. 2017. 145. S112-S113

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Education (2)：

- 2002 東京大学大学院理学系研究科生物科学専攻
- 2002 University of Tokyo Graduate School of Science Department of Biogical Sciences

Professional career (1)：

Ph.D (University of Tokyo)

Work history (5)：

2021/10 - 現在 National Institute of Health Sciences Division of Pharmacology Section Chief
2019/10 - 2021/09 Food Safety Commission Secretariat, Cabinet Office, Japan Assessment Methodology Development Office Deputy Director
2007/04 - 2019/09 Natl Inst of Health Sciences Div of Cellular and Molecular Toxicology Senior Researcher
2003/04 - 2007/03 Natl Inst of Health Sciences Div of Cellular and Molecular Toxicology Researcher
2002/04 - 2003/03 Natl Inst of Genetics Div of Mammalian Development Postdoctoral Fellow

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