Rchr
J-GLOBAL ID：200901080356743832
Update date: May. 14, 2024
Yasuhiko Yukuto
ヤスヒコ ユクト | Yasuhiko Yukuto
Affiliation and department：
Job title：
Senior researcher
Research field (1)：
Developmental biology
Research keywords (5)：
Reproductive and Developmental Toxicity
, トランスジェニック動物
, 遺伝子ノックアウト
, 発現制御
, 発生工学
Research theme for competitive and other funds (6)：
Papers (23)：
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Yukuto Yasuhiko, Miwa Ishigami, Satoshi Machino, Tatsuya Fujii, Masanori Aoki, Fumi Irie, Yasunari Kanda, Midori Yoshida. Comparison of the lower limit of benchmark dose confidence interval with no-observed-adverse-effect level by applying four different software for tumorigenicity testing of pesticides in Japan. Regulatory toxicology and pharmacology : RTP. 2022. 133. 105201-105201
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Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko, Yasunari Kanda. Transforming Growth Factor Beta Promotes the Expansion of Cancer Stem Cells <i>via</i> S1PR3 by Ligand-Independent Notch Activation. Biological and Pharmaceutical Bulletin. 2022. 45. 5. 649-658
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Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko, Motohiro Nishida, Yasunari Kanda. Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer. International journal of molecular sciences. 2022. 23. 4. 1967-1967
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Yusuke Okubo, Fumiaki Ohtake, Katsuhide Igarashi, Yukuto Yasuhiko, Yoko Hirabayashi, Yumiko Saga, Jun Kanno. Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal dependent and independent pathways. Development (Cambridge, England). 2021
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Toshime Igarashi, Yukuto Yasuhiko, Ryuichi Ono, Erika Tachihara, Miki Uchiyama, Atsuya Takagi, Yu Takahashi, Makiko Kuwagata, Satoshi Kitajima. Diverse unintended on-target mutations induced by zygote genome-editing using CRISPR/Cas9 system. Fundamental Toxicological Sciences. 2021. 8. 5. 161-167
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MISC (9)：
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Toshime Igarashi, Yukuto Yasuhiko, Ryuichi Ono, Erika Tachihara, Miki Uchiyama, Atsuya Takagi, Yu Takahashi, Makiko Kuwagata, Satoshi Kitajima. Germline-transmission in the knock-in mice of N0 generation with diverse and unintended on-target mutations induced by CRISPR/Cas9-mediated genome editing. 2021. 46. Supplement. P-91
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Toshime Igarashi, Yukuto Yasuhiko, Ryuichi Ono, Erika Tachihara, Yu Takahashi, Makiko Kuwagata, Satoshi Kitajima. CRISPR/Cas9-mediated genome editing of mouse zygotes induces diverse on-target unintentional mutations. Journal of Toxicological Sciences. 2020. 45. Supplement. P-180
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K. Takeda, I. Kou, N. Kawakami, Y. Yasuhiko, Y. Ogura, E. Imagawa, N. Miyake, N. Matsumoto, H. Sudo, T. Kotani, et al. Expanding the phenotype of DNAJC3 mutations: A case with hypothyroidism additionally to diabetes mellitus and multisystemic neurodegeneration Response. CLINICAL GENETICS. 2017. 92. 5. 563-564
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Yukuto Yasuhiko, Yoko Hirabayashi, Ryuichi Ono. Tbx6 regulates gene expression via binding sites in Long Terminal Repeats (LTR) of endogenous retrovirus during mouse embryogenesis. MECHANISMS OF DEVELOPMENT. 2017. 145. S112-S113
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武田和樹, 武田和樹, 武田和樹, 黄郁代, 小倉洋二, 小倉洋二, 川上紀明, 川上紀明, 小谷俊明, 小谷俊明, et al. TBX6遺伝子のnull mutationとhypomorphic risk haplotypeのcompound heterozygoteは先天性側弯症およびSpondylocostal dysostosisを引き起こす. 日本整形外科学会雑誌. 2017. 91. 8
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Education (2)：
- - 2002 東京大学大学院 理学系研究科 生物科学専攻
- - 2002 University of Tokyo Graduate School of Science Department of Biogical Sciences
Professional career (1)：
- Ph.D (University of Tokyo)
Work history (5)：
- 2021/10 - 現在 National Institute of Health Sciences Division of Pharmacology Section Chief
- 2019/10 - 2021/09 Food Safety Commission Secretariat, Cabinet Office, Japan Assessment Methodology Development Office Deputy Director
- 2007/04 - 2019/09 Natl Inst of Health Sciences Div of Cellular and Molecular Toxicology Senior Researcher
- 2003/04 - 2007/03 Natl Inst of Health Sciences Div of Cellular and Molecular Toxicology Researcher
- 2002/04 - 2003/03 Natl Inst of Genetics Div of Mammalian Development Postdoctoral Fellow
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