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J-GLOBAL ID：200901083456569677 Update date: Mar. 26, 2025

Iwama Atsushi

イワマアツシ | Iwama Atsushi

Affiliation and department：
Job title： Professor

Research field (1)： Immunology

Research theme for competitive and other funds (62)：

2024 - 2029 Pathogenec implication of hematopoietic stem cell aging in age-associated hematological malignancies
2020 - 2025 Analysis of stemness, aging and carcinogenesis using hematopoietic stem cell ex vivo amplification system
2019 - 2024 Characterization of chromatin replication associated with stem cell fate decision
2019 - 2024 Deciphering of the epigenetic machinery that determines the hallmarks of hematopoietic stem cell aging
2021 - 2023 新規マウスモデルを用いた多発性骨髄腫のエピジェネティック治療法の開発

2019 - 2020 Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell aging

2018 - 2020 Pathogenic role of niche aging in the development of age-associated hematological malignancies

2017 - 2019 Role of the polycomb-group protein Pcgf1 in hematopoietic

2016 - 2019 Epigenetic pathogenesis of multiple myeloma related to drug resistance

2016 - 2019 Importance of loss-of-function of ARID family proteins in liver cancer

2015 - 2019 Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell aging

2014 - 2019 Epigenetics and stress signals in stem cell aging

2014 - 2019 Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell aging

2014 - 2019 Establishing a new paradigm of the pathogenesis of diseases through the understanding of stem cell aging

2016 - 2018 Tumor suppressor role of BCOR in hematopoiesis

2015 - 2018 Pathological role of the dysregulated polycomb functions in hematological malignancies

2014 - 2017 HSC regulation by TERT-binding proteins, chromatin remodeling factor BRG1/BRM

2014 - 2017 Analysis of the mechanism of myelofibrosis with Smad3 knock out mice

2014 - 2017 Epigenetic dysregulation in myelodysplastic syndromes in the absence of Ezh2

2014 - 2016 Abberant histone methylation as a therapeutic target in multiple myeloma

2013 - 2016 The regulatory machinery of histone methyltransferases ESET in normal liver and liver cancer

2013 - 2015 白血病幹細胞における新規治療標的としての長鎖非蛋白コードRNAの同定と機能解析

2012 - 2015 Role of epigenetic dysregulation in the pathogenesis of hematological malignancies

2010 - 2015 Clarification of molecular mechanisms regulating lineage commitment taking place on the way from multipotent hematopoietic progenitors to unipotent T cell progenitors

2011 - 2013 癌幹細胞の特性維持に関わる長鎖非蛋白コードRNAの同定と新規治療標的としての検討

2011 - 2013 Analysis of the function of LR11 on normal leukocytes and leukemia cells

2011 - 2013 Molecular mechanism of MLL mutant-induced MDS

2011 - 2012 Direct reprogramming of hematopoietic cells into hematopoietic stem cells

2009 - 2011 Regulation of hematopoietic and leukemic stem cells by the polycomb complexes

2009 - 2010 Investigation of novel target genes regulated by polycomb group genes in hepatocellular carcinoma

2008 - 2009 ポリコーム複合体を中心としたエピゲノムネットワークの解析

2007 - 2008 Investigation of cancer stem cell system in hepatocellular carcinoma

2007 - 2008 自家培養細胞移植の新規分子基盤の確立とその応用

2006 - 2007 Epigenetic regulation of hematopoietic stem cell self renewal

2006 - 2007 ポリコーム遺伝子Bmi-1によるエピジェネティクス制御

2006 - 2007 生殖系幹細胞の自己複製制御機構の解明

2006 - 2007 白血病幹細胞の自己複製の分子基盤の解明

2002 - 2006 骨髄幹細胞の可塑性とそのメカニズム

2005 - 2005 胎児型造血幹細胞の新しい純化法と遺伝子プロファイリング

2005 - 2005 ポリコーム複合体によるDNAメチル化の維持と幹細胞機能

2004 - 2005 Regulation of hematopoietic stem cell self-renewal by a polycomb gene product Bmi1

2004 - 2005 ポリコーム遺伝子Bmi-1による精子幹細胞の未分化性維特機構

2003 - 2003 造血幹細胞の可視化とその応用

2002 - 2003 造血幹細胞をニッシェに導くホーミングレセプターのクローニング

2002 - 2003 Role of STAT5 in regulation of hematopoietic stem cell function

2002 - 2003 Development of a novel molecular therapy for rheumatoid arthritis by regulation of Th1/Th2 differentiation

2001 - 2003 Plasticity and diversity of hematopoietic stem cells

2001 - 2002 転写調節因子による骨髄球系樹状細胞の分化と機能制御

2001 - 2001 C/EBP転写因子ファミリーによる骨髄球分化の制御機構

2001 - 2001 レンチウイルスベクターによるHIV感染症の遺伝子治療

2000 - 2001 Transcriptional regulation of eosinophil development

2000 - 2001 ANALYSIS OF IMMUNE REGULATION BY ADHESION MOLECULE COMPLEX ON KILLER LYMPHOCYTES

2000 - 2000 急性骨髄性白血病の病態形成における転写因子C/EBPαの遺伝子変異の生物学的意義

2000 - 2000 LFA-1/DNAM-1リンパ球接着分子複合体による免疫制御機構の解析

2000 - 2000 転写調節による好酸球分化の制御機構の解析

1996 - 1997 Functional analyzes for common receptor tyrosine kinases of hematopoietic stem cells and vascular endothelial cells

1996 - 1996 受容体型チロシンキナーゼSTK/RONの血液細胞における機能解析

1994 - 1994 全能性幹細胞における受容体型チロシンキナーゼtieの発現

1994 - 1994 c-kitがん原遺伝子の発現と機能

1993 - 1994 Cloning of Seel-renewal factor receptors from hemopoietic stem cells

1993 - 1993 造血幹細胞の増殖、分化に関与する受容体型チロシンキナーゼTIEファミリーの解析

1993 - 1993 血液幹細胞に特異的に発現されるTIE受容体のリガンドの検索

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Papers (304)：

Takao Yogo, Hans Jiro Becker, Takaharu Kimura, Satoshi Iwano, Takahiro Kuchimaru, Atsushi Miyawaki, Tomomasa Yokomizo, Toshio Suda, Atsushi Iwama, Satoshi Yamazaki. Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation. Cell reports. 2025. 44. 2. 115241-115241
Yuki Yamanashi, Shinpei Takamaru, Atsushi Okabe, Satoshi Kaito, Yuto Azumaya, Yugo R. Kamimura, Kenzo Yamatsugu, Tomoya Kujirai, Hitoshi Kurumizaka, Atsushi Iwama, et al. Chemical catalyst manipulating cancer epigenome and transcription. Nature Communications. 2025. 16. 1
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, et al. Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization. Nature Communications. 2024. 15. 1
Naru Sato, Susumu Goyama, Yu-Hsuan Chang, Takeshi Fujino, Tamami Denda, Shuhei Asada, Shiori Shikata, Xiaoxiao Liu, Taishi Yonezawa, Reina Takeda, et al. CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate Immunity. 2024
Sudip Kumar Paul, Motohiko Oshima, Ashwini Patil, Masamitsu Sone, Hisaya Kato, Yoshiro Maezawa, Hiyori Kaneko, Masaki Fukuyo, Bahityar Rahmutulla, Yasuo Ouchi, et al. Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model. Nature communications. 2024. 15. 1. 4772-4772

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MISC (222)：

大島基彦, 高山直也, 中島やえ子, 小出周平, 原田浩徳, 原田結花, Ding Ye, 明星智洋, 岩間厚志. 幹細胞分画を用いたクロマチン特性解析による骨髄異形成症候群の病態解明. 日本血液学会学術集会. 2023. 85回. 398-398
福田貴規, 中島やえ子, 青山和正, 小出周平, 山下真幸, 大島基彦, 岩間厚志. ポリコーム抑制複合体1.1は炎症性細胞死を抑制的に制御する. 日本血液学会学術集会. 2023. 85回. 565-565
神谷高博, 大島基彦, 小出周平, 中島やえ子, 青山和正, 海渡智史, 糸川直樹, 山下真幸, 土岐典子, 片岡圭亮, et al. シングルセルRNAシークエンスを用いた多発性骨髄腫の治療抵抗性に関わる不均一性の解明. 日本血液学会学術集会. 2023. 85回. 769-769
鈴木雄太郎, 中島やえ子, 黒澤修兵, オラ・リズク, 越智陽太郎, 昆彩奈, 伊藤悦朗, 小川誠司, 岩間厚志. GATA1s変異とSTAG2・EZH2変異の協調は異常な巨核球産生を介し致死性の骨髄線維症を誘発する. 日本血液学会学術集会. 2023. 85回. 666-666
加藤裕子, 横溝貴子, 指田吾郎, 岩間厚志, 宮城聡. Phip遺伝子の造血における役割. 日本生化学会大会(Web). 2023. 96th

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Lectures and oral presentations (28)：

幹細胞分画を用いたクロマチン特性解析による骨髄異形成症候群の病態解明
(日本血液学会学術集会 2023)
TOPORSの機能抑制はDNMT1の安定化を介してDNAメチル化阻害剤の効果を増強する
(日本血液学会学術集会 2023)
ポリコーム抑制複合体1.1は炎症性細胞死を抑制的に制御する
(日本血液学会学術集会 2023)
シングルセルRNAシークエンスを用いた多発性骨髄腫の治療抵抗性に関わる不均一性の解明
(日本血液学会学術集会 2023)
レパトア特異性を活用したシングルセルRNAシークエンスが明らかにする多発性骨髄腫の不均一性(Single-Cell RNA Sequencing with Repertoire Clonality Reveals the Heterogeneity of Multiple Myeloma)
(International Journal of Myeloma 2023)

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Professional career (1)：

M.D. (Kumamoto University)

Work history (1)：

2005/03 - 2018/09 Chiba University Graduate School of Medicine

Association Membership(s) (7)：

International Society for Stem Cell Research , TheAmerican Society of Hematology , 日本癌学会 , 日本生化学会 , 日本分子生物学会 , 日本免疫学会 , 日本血液学会

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