Research theme for competitive and other funds (10):
2016 - 2019 グルカゴンシグナルを指標とした食餌性亜硝酸塩による抗糖尿病効果の解明
2013 - 2016 食餌性由来亜硝酸塩によるAMPK活性化機構の解明
2006 - 2007 生体内における亜硝酸由来NO生成因子の解明
2004 - 2005 腎虚血-再潅流時の腎臓内亜硝酸由来NO産生の病態生理学的役割の解明
2002 - 2003 生体内でのフラボノイド代謝物の抗酸化機序の解明
2000 - 電子スピン共鳴(ESR)法を用いた生体由来一酸化窒素(NO)測定に関する基礎的研究
2000 - Application of Electron Spin resonance spectroscopy for quantitation of nitric oxide in living system
1997 - 生体内活性酸素測定法の開発
1997 - Detection of reactive oxygen species in in vivo samples
糖尿病性腎症モデルラットにおける亜硝酸塩による腎保護作用の検討
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Papers (73):
Masateru Kondo, Masaki Imanishi, Keijo Fukushima, Raiki Ikuto, Yoichi Murai, Yuya Horinouchi, Yuki Izawa-Ishizawa, Mitsuhiro Goda, Yoshito Zamami, Kenshi Takechi, et al. Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis. American journal of hypertension. 2019. 32. 3. 249-256
Yuki Izawa-Ishizawa, Masaki Imanishi, Yoshito Zamami, Hiroki Toya, Tomoko Nagao, Marin Morishita, Koichi Tsuneyama, Yuya Horinouchi, Yoshitaka Kihira, Kenshi Takechi, et al. Development of a novel aortic dissection mouse model and evaluation of drug efficacy using in-vivo assays and database analyses. Journal of hypertension. 2019. 37. 1. 73-83
Yuya Horinouchi, Yasumasa Ikeda, Keijo Fukushima, Masaki Imanishi, Hirofumi Hamano, Yuki Izawa-Ishizawa, Yoshito Zamami, Kenshi Takechi, Licht Miyamoto, Hiromichi Fujino, et al. Renoprotective effects of a factor Xa inhibitor: fusion of basic research and a database analysis. Scientific reports. 2018. 8. 1. 10858-10858
Hirofumi Hamano, Yasumasa Ikeda, Hiroaki Watanabe, Yuya Horinouchi, Yuki Izawa-Ishizawa, Masaki Imanishi, Yoshito Zamami, Kenshi Takechi, Licht Miyamoto, Keisuke Ishizawa, et al. The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2018. 33. 4. 586-597