Rchr
J-GLOBAL ID：200901099902059320
Update date: Jan. 30, 2024
Nakai Toshiki
ナカイ トシキ | Nakai Toshiki
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Research field (3)：
Structural biochemistry
, Cell biology
, Molecular biology
Research keywords (10)：
PTHrP
, membrane protein
, membrane topology
, Lewy body
, synuclein
, synphilin
, γ-secretase
, presenilin
, protein sorting
, functional genetic screening
Research theme for competitive and other funds (10)：
2001 - 2002 Establishment of ?-secretes assay and functional analysis of Presenilin
1999 - 2000 Identification of interacting molecules with α-synuclein and of their function in the pathology of neurodegenerative diseases
1996 - 1997 Intersection between familial Alzheimer's disease and Notch signal transduction pathway
1996 - 1997 Molecular mechanism of perexisomal protein import into peroxisomes.
アルツハイマー病関連遺伝子産物の機能解析
ペロキシゾーム生合成に関する研究
細胞内タンパク分解系に関する研究
Functional analyses of Alzheimer's disease-related gene products
Study on peroxisome biogenesis
Study on intracellular protein degradation
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Papers (6)：
Yoshihiro Amaya, Toshiki Nakai, Satoshi Miura. Evolutionary well-conserved region in the signal peptide of parathyroid hormone-related protein is critical for its dual localization through the regulation of ER translocation. JOURNAL OF BIOCHEMISTRY. 2016. 159. 4. 393-406
Yoshihiro Amaya, Toshiki Nakai, Keiichi Komaru, Masayuki Tsuneki, Satoshi Miura. Cleavage of the ER-targeting signal sequence of parathyroid hormone-related protein is cell-type-specific and regulated in Cis by its nuclear localization signal. JOURNAL OF BIOCHEMISTRY. 2008. 143. 4. 569-579
A Ryo, T Togo, T Nakai, A Hirai, M Nishi, A Yamaguchi, K Suzuki, Y Hirayasu, H Kobayashi, K Perrem, et al. Prolyl-isomerase Pin1 accumulates in Lewy bodies of Parkinson disease and facilitates formation of alpha-synuclein inclusions. JOURNAL OF BIOLOGICAL CHEMISTRY. 2006. 281. 7. 4117-4125
M Tamura, T Nagasawa, T Tange, K Miyano, S Kobayashi, T Nakai, S Miura. A new type of O-2(-)-generating tool for oxidative stress studies by remodeling neutrophil NADPH oxidase. JOURNAL OF BIOTECHNOLOGY. 2005. 120. 4. 421-429
E Iseki, N Takayama, Y Furukawa, W Marui, T Nakai, S Miura, K Ueda, K Kosaka. Immunohistochemical study of synphilin-1 in brains of patients with dementia with Lewy bodies - synphilin-1 is non-specifically implicated in the formation of different neuronal cytoskeletal inclusions. NEUROSCIENCE LETTERS. 2002. 326. 3. 211-215
ｍore...
MISC (5)：
Membrane Topology of Alzheimer's Disease-related Presenilin 1. The Journal of Biological Chemistry. 1999. 274. 33. 23647
AAA スーパーファミリータンパク質(共著). 細胞工学. 1996. 15. 7. 968
Peroxisome assembly factor-2, a putative ATP are cloned by functional complementation on a peroxisome-deficient mammalian cell mutant(共著). Nature Genetics. 1995. 11. 4. 395-401
Multiple genes including a member of the AAA family are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria(共著). Mol. Cell Biol. 1995. 15. 13651
Divalent metal ion-dependent mitochondrial degradation of unassembled subunits 2 and 3 of cytochrome c oxidase. J. Biochem. 1994. 116. 752
Education (4)：
- 1984 The University of Tokyo
- 1984 The University of Tokyo Graduate School, Division of Bioresearch
- 1982 The University of Tokyo Faculty of Science
- 1982 The University of Tokyo Faculty of Science
Professional career (1)：
(BLANK)
Work history (4)：
2007/04 - 現在 Yokohama City University School of Medicine assistant professor
1995/03 - 2007/03 Yokohama City University School of Medicine assistant professor
1984/04 - 1995/02 Meiji Health Science Institute Researcher
Yokohama City University School of Medicine Medical Course Graduate School of Medicine Degree Program
Association Membership(s) (2)：
日本生化学会
, 日本分子生物学会
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