Ogawa Takuya

オガワタクヤ | Ogawa Takuya

Affiliation and department：
Job title： Associate Professor

Research field (3)： Orthopedics , Cell biology , Molecular biology

Research keywords (18)：ゲノム編集 , ウイルスベクター , microRNA , 分化 , L-セリン , 発現制御 , RANK , 発生・分化 , 骨・軟骨代謝学 , セリン , シグナル伝達 , 細胞・組織 , アミノ酸 , 細胞分化 , マクロファージ , 破骨細胞 , 骨芽細胞 , 骨代謝

Research theme for competitive and other funds (5)：

2022 - 2025 ロコモ改善を志向した骨代謝を制御する天然機能分子の探索
2022 - 2025 Exploration of the regulatory mechanism of cell-cell fusion in osteoclastogenesis by CRISPR screening and proximity labeling
2012 - 2014 Significance of L-serine in intercellular communication between cancer cells and tumor-associated macrophages
2010 - 2011 L-serine starvation response in osteoclast precursors and its physiological significance in the bone marrow microenvironment
2008 - 2009 L-serine regulation of RANK signaling machinery and its role in bone metabolism

Papers (37)：

Misaki Watanabe, Tadahiro Yahagi, Takahiro Shirayama, Katsunori Miyake, Hitoshi Kotani, Takuya Ogawa, Keiichi Matsuzaki. Effects of a Whole Plant Extract of Scutellaria rubropunctata var. rubropunctata on Bone Metabolism with Estrogen Receptor Activation. Plants. 2022. 11. 16. 2075-2075
Hiromi Funayama, Itaru Tashima, Satoru Okada, Takuya Ogawa, Hideki Yagi, Hiroyuki Tada, Ryo Wakita, Yoshinobu Asada, Yasuo Endo. Effects of Zoledronate on Local and Systemic Production of IL-1β, IL-18, and TNF-α in Mice and Augmentation by Lipopolysaccharide. Biological & pharmaceutical bulletin. 2019. 42. 6. 929-936
Momoko Hamano, Yurina Haraguchi, Tomoko Sayano, Chong Zyao, Yashiho Arimoto, Yui Kawano, Kazuki Moriyasu, Miyako Udono, Yoshinori Katakura, Takuya Ogawa, et al. Enhanced vulnerability to oxidative stress and induction of inflammatory gene expression in 3-phosphoglycerate dehydrogenase-deficient fibroblasts. FEBS Open Bio. 2018. 8. 6. 914-922
Miyuki Ookura, Tatsuya Fujii, Hideki Yagi, Takuya Ogawa, Shinji Kishi, Naoko Hosono, Hiroko Shigemi, Takahiro Yamauchi, Takanori Ueda, Akira Yoshida. YM155 exerts potent cytotoxic activity against quiescent (G0/G1) multiple myeloma and bortezomib resistant cells via inhibition of survivin and Mcl-1. Oncotarget. 2017. 8. 67. 111535-111550
Tomoko Sayano, Yuki Kawano, Wataru Kusada, Yashiho Arimoto, Kayoko Esaki, Momoko Hamano, Miyako Udono, Yoshinori Katakura, Takuya Ogawa, Hisanori Kato, et al. Adaptive response to l-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts. FEBS Open Bio. 2016. 6. 4. 303-316

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MISC (9)：

Norihiro Ishida-Kitagawa, Takuya Ogawa. IDENTIFICATION OF A NOVEL PARTNER OF DAP12 IN THE REGULATION OF ACTIN-RING FORMATION IN OSTEOCLASTS. OSTEOPOROSIS INTERNATIONAL. 2011. 22. S606-S606
Tatsuo Takeya, Anton Bahtiar, Norihiro Ishida-Kitagawa, Takuya Ogawa. ISOLATION OF L-SER ANALOGS AS NOVEL INHIBITORS OF OSTEOCLASTOGENESIS AND BONE TURNOVER WITH A DISTINCT FUNCTIONAL MECHANISM. OSTEOPOROSIS INTERNATIONAL. 2010. 21. 211-211
Extracellular L-Serine controls the activation of nutrient-sensing signal in osteoclast precursors. Amino acid research. 2010. 4. 2. 167-169
An essential role of extracellular L-serine for RANKL-induced osteoclastogenesis in vitro. Amino acid research. 2009. 3. 1. 63-65
Takuya Ogawa, Toshiki Sakai, Anton Bahtiar, Norihiro Ishida-Kitagawa, Tatsuo Takeya. A Novel Role of L-Serine for the Activation of Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL)-RANK Signaling Machinery in Osteoclastogenesis in vitro. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S150-S150

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Lectures and oral presentations (42)：

タンパク質スプライシングによる融合破骨細胞の選択的脱落法の開発
(第13回国際医療福祉大学学術大会 2023)
Cas9-インテグラーゼヘテロ二量体化によるゲノム編集法の改良
(第12回国際医療福祉大学学術大会 2022)
エストロゲン受容体活性化作用を有する琉球弧植物の骨代謝への影響
(日本薬学会第142年会 2022)
Heterodimerization of Cas9-DNA binding protein for Improvement of Genome Edditing.
(2021)
ウイルス様小胞によるゲノム編集法の改良
(第10回国際医療福祉大学学術大会 2020)

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Professional career (1)：

博士(バイオサイエンス) (奈良先端科学技術大学院大学)

Work history (7)：

2022/04 - 現在 International University of Health and Welfare Department of Pharmaceutical Sciences, School of Pharmacy Associate Professor
2012/04 - 2022/03 International University of Health and Welfare Department of Pharmaceutical Sciences, School of Pharmacy Lecturer
2011/10 - 2012/03 Nara Institute of Science and Technology Graduate School of Biological Sciences
2007/04 - 2011/09 Nara Institute of Science and Technology Graduate School of Biological Sciences
2006/10 - 2007/03 Nara Institute of Science and Technology Graduate School of Biological Sciences

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Awards (1)：

2008/03 - 加藤記念バイオサイエンス研究振興財団第19回加藤記念研究助成

Association Membership(s) (5)：

JAPANESE SOCIETY FOR AMINO ACID SCIENCES , JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , Japan Society of Nutrition and Food Science , American Society for Bone and Mineral Research

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