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J-GLOBAL ID：201301005156772022
Update date: Mar. 26, 2025 Hamamoto Hiroshi
ハマモト ヒロシ | Hamamoto Hiroshi
Yamagata University Faculty of Medicine
About Yamagata University Faculty of Medicine
Job title： Professor
Homepage URL (1)： https://infectiousdiseases-yamagata-u.jp
Research keywords (7)：
Host-Microbe interaction
, Chemical Biology
, Antimicrobials
, 細菌感染
, サイトカイン
, 自然免疫
, シグナル伝達
Research theme for competitive and other funds (15)： - 2023 - 2026 新規抗菌治療薬のメナキノン誘導を伴う殺菌メカニズムの解明
- 2022 - 2025 歯周病原細菌の9型分泌機構における選択的分泌メカニズムの解明
- 2022 - 2025 歯周病原細菌などのバクテロイディア綱細菌固有のリポタンパク質輸送機構の解明
- 2021 - 2024 食品由来の強力な自然免疫活性化能を示す新規物質の作用機序解析
- 2019 - 2022 Mechanism of action analysis of novel antibiotics in host factor contribution to therapeutic efficacy
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- Aye Mya Sithu Shein, Dhammika Leshan Wannigama, Cameron Hurst, Peter N Monk, Mohan Amarasiri, Thidathip Wongsurawat, Piroon Jenjaroenpun, Phatthranit Phattharapornjaroen, William Graham Fox Ditcham, Puey Ounjai, et al. Phage cocktail amikacin combination as a potential therapy for bacteremia associated with carbapenemase producing colistin resistant Klebsiella pneumoniae. Scientific reports. 2024. 14. 1. 28992-28992
- Hiroshi Hamamoto. Silkworm model of bacterial infection facilitates the identification of lysocin E, a potent, ultra-rapid bactericidal antibiotic. The Journal of antibiotics. 2024. 77. 8. 477-485
- Pablo Iturbe, Alvaro San Martín, Hiroshi Hamamoto, Marina Marcet-Houben, Toni Galbaldón, Cristina Solano, Iñigo Lasa. Noncontiguous operon atlas for the Staphylococcus aureus genome. microLife. 2024. 5. uqae007
- Aye Mya Sithu Shein, Dhammika Leshan Wannigama, Cameron Hurst, Peter N Monk, Mohan Amarasiri, Vishnu Nayak Badavath, Phatthranit Phattharapornjaroen, William Graham Fox Ditcham, Puey Ounjai, Thammakorn Saethang, et al. Novel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023. 168. 115793-115793
- Junhao Fu, Yosuke Nakata, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Molecular Editing Enhances Oxidation Resistance of Mena-quinone-Targeting Antibiotics Lysocin E and WAP-8294A2. Chemistry - A European Journal. 2023
- 浜本洋, 石島早苗, PANTHEE Suresh, 関水和久. Cryptococcus neoformansの病原性因子の網羅的探索. 関東医真菌懇話会プログラム・抄録集. 2022. 41st
- 浜本洋, 石島早苗, 関水和久. Cryptococcus neoformansの病原性発揮機構の網羅的な理解. 日本医真菌学会雑誌. 2022. 63. Supplement 1
- 浜本 洋. 微生物と宿主の相互作用を利用する新しい作用機序の抗生物質-ライソシンEの治療効果の発揮機構の解明. ファルマシア. 2022. 58. 10. 959-963
- 浜本洋, PANTHEE Suresh, PAUDEL Atmika, 宮下惇嗣, 関水和久, 関水和久. A novel antibiotic Lysocin E exhibits high therapeutic efficacy through host-microbe interaction. 日本細菌学雑誌(Web). 2022. 77. 1
- 浜本, 洋. カイコを用いた医真菌の病原性の評価と抗真菌薬の開発-Evaluation of pathogenicity of medical mycology and development of antifungal drugs using silkworm model. Medical mycology research. 2021. 12. 1. 27-33
Professional career (1)：
- 博士(薬学) (東京大学)
- 2023/04 - 現在 Yamagata University Faculty of Medicine Professor
- 2016/04 - 2023/03 Teikyo University Institute of Medical Mycology
- 2008/02 - 2016/03 The University of Tokyo
- 2006/07 - 2008/01 Genome Pharmaceutical Institute Principal researcher
- 2006/04 - 2006/06 東京大学大学院 薬学系研究科 助教
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- 2023/01 - 現在 Journal of Antibiotics (Tokyo), Section Editor
- 2018/04 - 現在 ナショナルバイオリソースプロジェクト「カイコ」 運営委員
- 2007/06 - 現在 Drug Discovery and Therapeutics誌, Associate Editor
- 2021/03 - 2024/03 日本医療開発機構 AMED課題評価委員
- 2024/08 - Japanese Society for Bacterilogoy Kobayashi Rokuzo Memorial Award Development of next-generation antimicrobial agents with unique mechanisms of action.
- 2023/11 - Sumiki-Umezawa Memorial Award
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