Kinugawa Shintaro

キヌガワシンタロウ | Kinugawa Shintaro

Affiliation and department：
Job title：准教授
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/60399871.ja.html

Research field (1)： Cardiology

Research keywords (17)：酸化ストレス , ミトコンドリア , 心不全 , 小動物用トレッドミル , 運動能力 , メタボリックシンドローム , アンジオテンシンII , ミトコンドリア呼吸能 , ミトコンドリア機能 , 骨格筋 , NAD(P)H oxidase , 心筋リモデリング , 活性酸素 , 転写因子 , 心血管病 , DNA , ストレス応答

Research theme for competitive and other funds (28)：

2022 - 2025 Pathobiological role of Ca2+/calmodulin-dependent PDE1 in HFpEF
2022 - 2025 Pathophysiology and Clinical Impact of Anemia in Patients with Advanced Heart Failure
2022 - 2025 Golgi apparatus-centered organelle network in cardiac remodeling
2022 - 2024 O結合グリコシル化制御に基づくサルコペニアの新規治療法開発
2021 - 2024 マイオカインによる老化進展制御機構の解明

2018 - 2023 Role of alpha-defensins derived from the small intestine and gut microbiota in heart failure

2018 - 2021 Study on the mechanism of regulation of mitochondrial function by brain-derived neurotrophic factor

2017 - 2020 The role of protein lysine-acetlation in congenital heart disease

2015 - 2018 Role of epicardial adipose tissue mitochondria in cardiovascular disease

2015 - 2018 Effects of skeletal muscle ischemic preconditioning for fatigability and damage protection

2015 - 2018 Regulatory mechanism of mitochondrial iron contents by mitoMEET in cardiac remodeling

2015 - 2017 Regulatory mechanism of mitochondrial morphology by Nox4 and treatment for heart failure

2015 - 2017 The role of Helicobacter Pylori in heart failure and effect of eradiation of Helicobacter Pylori

2014 - 2017 Immunohistochemical identification of Propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients

2014 - 2017 The role of mitoNEET on the regulation of mitochondrial function in skeletal muscle failure

2012 - 2016 Comprehensive risk assessment by using myocardial flow reserve in patients with diastolic dysfunction

2013 - 2015 Regulating mechanism of mitochondrial function by Nox4 in cardiac remodeling

2012 - 2015 Nutritional status and clinical outcomes in patients with heart failure: Clinical nutritional epidemiology

2012 - 2015 Role of natural killer T cells in myocardial remodeling and its therapeutic implication.

2011 - 2015 Role of natural killer T cells in chronic inflammation of atherogenesis

2011 - 2015 Adaptive servo-ventilation improves cardiac sympathetic nerve activity in patients with heart failure: Evaluation by cardiac 11C-Hydroxyephedrine positron emission tomography

2013 - 2014 Development of novel preventive strategy for post-infarct cardiac rupture via the regulation of inflammatory process by the activation of natural killer T cells

2011 - 2013 Resistance training with blood flow restriction: from basic physiological study to creative clinical application

2012 - 2012 Development of novel therapeutic strategy for atherosclerotic vascular diseases via the activation of natural killer T cells

2008 - 2012 Regulation of mitochondrial ROS signaling in the cardiovascular stress response

2009 - 2011 Study on the molecular mechanisms and treatment for mitochondrial regulation in cardiac remodeling

2008 - 2010 Study on the molecular mechanisms and treatment for the impaired exercise capacity in metabolic syndrome

2006 - 2007 酸化ストレス制御による心不全における運動能力改善を目指した新規治療法の開発

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Papers (201)：

Shota Ikeda, Keisuke Shinohara, Koshiro Tagawa, Takeshi Tohyama, Junji Kishimoto, Masaya Kazurayama, Shinji Tanaka, Masamitsu Yamaizumi, Hirokazu Nagayoshi, Kensuke Toyama, et al. Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population. Scientific Reports. 2024. 14. 1
Tatsuya Watanabe, Takeshi Tohyama, Masataka Ikeda, Takeo Fujino, Toru Hashimoto, Shouji Matsushima, Junji Kishimoto, Koji Todaka, Shintaro Kinugawa, Hiroyuki Tsutsui, et al. Development of Deep-Learning Models for Real-Time Anaerobic Threshold and Peak VO2 Prediction during Cardiopulmonary Exercise Testing. European journal of preventive cardiology. 2023
Takashi Yokota, Arata Fukushima, Miyuki Tsuchihashi-Makaya, Takahiro Abe, Shingo Takada, Takaaki Furihata, Naoki Ishimori, Takeo Fujino, Shintaro Kinugawa, Masayuki Ohta, et al. The AppCare-HF randomized clinical trial: a feasibility study of a novel self-care support mobile app for individuals with chronic heart failure. European Heart Journal - Digital Health. 2023. 4. 4. 325-336
Nobuyuki Enzan, Shouji Matsushima, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Taishi Yamamoto, Masashi Sada, Ryo Miyake, Yoshitomo Tsutsui, Ryohei Nishimura, et al. ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts. Circulation research. 2023. 132. 9. 1110-1126
Ryosuke Shirakawa, Takayuki Nakajima, Aya Yoshimura, Yukako Kawahara, Chieko Orito, Miwako Yamane, Haruka Handa, Shingo Takada, Takaaki Furihata, Arata Fukushima, et al. Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults. Scientific Reports. 2023. 13. 1

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MISC (290)：

松島将士, 円山信之, 井手友美, 絹川真太郎, 筒井裕之. 我が国における心筋症の臨床的特徴-臨床個人調査票データベース解析-. 日本心不全学会学術集会プログラム・抄録集. 2021. 25th
松島将士, 円山信之, 井手友美, 絹川真太郎, 筒井裕之. 心不全における貧血の意義. 日本心不全学会学術集会プログラム・抄録集. 2021. 25th
Symposium2-5. Japanese Journal of Physical Fitness and Sports Medicine. 2020. 69. 1. 22-22
Hideo Nambu, Shingo Takada, Satoshi Maekawa, Naoya Kakutani, Takaaki Furihata, Akimichi Saito, Arata Fukushima, Takashi Yokota, Shintaro Kinugawa. Empagliflozin Restores Lowered Exercise Endurance Capacity via the Activation of Skeletal Muscle Fatty Acid Oxidation in Murine Heart Failure. CIRCULATION. 2019. 140
角谷尚哉, 吉田一郎, 福島新, 中村梨沙子, 塚田貴紀, 絹川真太郎, 安斉俊久. 重複障害を有する超高齢心疾患患者に対するリハビリテーションの工夫難渋重症例をどのように対応するか? 後期高齢心不全患者に対する急性期離床プログラムの開発と運用. 日本循環器学会学術集会抄録集. 2019. 83回. CS4-1

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Professional career (1)：

医学博士 (九州大学)

Work history (3)：

2020/04 - 現在九州大学大学院医学研究院
2012/11 - 2020/03 北海道大学医学系研究科講師
2007/05 - 2012/10 北海道大学医学(系)研究科(研究院) 助教

Awards (2)：

2013/07 - 日本心臓リハビリテーション学会木村登賞
1997/10 - 第1回日本心不全学会YIA最優秀賞

Association Membership(s) (6)：

国際心臓研究会日本部会 , JAPANESE HEART FAILURE SOCIETY , JAPANESE COLLEGE OF CARDIOLOGY , 日本心臓リハビリテーション学会 , THE JAPANESE CIRCULATION SOCIETY , THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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