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J-GLOBAL ID：201401030522702123 Update date: Mar. 04, 2025

Takata Takumi

タカタタクミ | Takata Takumi

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Affiliation and department：

Research field (2)： Nutrition and health science , Structural biochemistry

Research keywords (8)：クリスタリン , ヒートショックプロテイン , シャペロン , 電磁波 , 水晶体 , 加齢性疾患 , フォールディング , D-アミノ酸

Research theme for competitive and other funds (6)：

2023 - 2026 蛋白質中トリプトファン残基の段階的酸化を標的とした新しい光老化科学の基盤研究
2020 - 2023 蛋白質分子内の老化を可視化する革新的研究
2021 - 蛋白質中D-アミノ酸を基盤とした未知生命科学研究領域の開拓
2017 - 2020 Isomerization of Aspartate residue as a new indicator of aging
2018 - 2018 加齢に応じてタンパク質中に蓄積する異性化アミノ酸残基の生理的意義を解明する研究

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Papers (46)：

Jiayue Sun, Toshiya Matsubara, Tamaki Koide, Kirsten Lampi, Larry David, Takumi Takata. Characterization of different-sized human αA-crystallin homomers and implications to Asp151 isomerization. PLOS ONE. 2024
Jiayue Sun, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Takumi Taka. Characterization of βB2-crystallin tryptophan mutants reveals two different folding states in solution. Protein Science. 2024. 33. 7
Amber D Rolland, Takumi Takata, Micah T Donor, Kirsten J Lampi, James S Prell. Eye lens β-crystallins are predicted by native ion mobility-mass spectrometry and computations to form compact higher-ordered heterooligomers. Structure (London, England : 1993). 2023
Toshiyuki Chatake, Yasuhide Yanagisawa, Risa Murakami, Tadanori Ohsugi, Hiroyuki Sumi, Takumi Takata, Aya Okuda, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama. Characterization of K-binding factor involved in water-soluble complex of menaquinone-7 produced by Bacillus subtilis natto. Journal of biochemistry. 2023. 174. 4. 383-389
Identification of D-amino acid residues in proteins using mass spectrometry. BUNSEKI KAGAKU. 2022. 71. 6. 319-324

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MISC (19)：

Takumi Takat, Noriko Fujii. The spontaneous isomerization of aspartate residues in lens crystallin. 2019. 91. 3. 322-328
Takumi Takata. Heat stability and chaperone like function of aged lens protein mimics. 2019
藤井紀子, 高田匠, 金仁求. 蛋白質中のD-アミノ酸と老化. 臨床免疫・アレルギー科. 2018. 70. 467-474
Takumi Takata. 水晶体構成蛋白質中におけるアミノ酸の自発的化学修飾が引き起こす白内障発症機構に関する研究. 日本白内障学会誌. 2018. 30. 7-12
Noriko Fujii, Takumi Takata. 生命科学におけるパラキラリティーの重要性. 日本眼薬理. 2017. 31. 20-27

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Books (4)：

The Importance of the Idea of“Parachirality” in Life Science.
Elsevier Inc 2017 ISBN:9780128128244
D-Amino acids: Physiology, Metabolism, and Application
Springer 2016 ISBN:9784431560753
皮膚蛋白質中のアスパラギン酸残基異性体と紫外線による皮膚老化の関連性
シーエムシー出版 2015
D-Amino Acids: A New Frontier in Amino Acid and Protein Rsearch-practical Methods and Protocol's
Nova Science Publishers, New York 2007

Lectures and oral presentations (138)：

ヒト水晶体内部シャペロン様分子αB-Crystallin中において部位特異的に修飾を受けるAsp部位の重要性
(第97回日本生化学会 2024)
Oxidation models of βB2-crystallin and their insights of cataract formation
(2024)
ヒト水晶体内部シャペロン様分子αB-Crystallin中において部位特異的に修飾を受けるAsp部位の重要性
(第97回日本生化学会 2024)
X線小角散乱法を用いたβB2-クリスタリン酸化モデルフォールディング経路の解析
(第63回白内障学会総会、第50回水晶体研究会 2024)
Analysis of the Susceptible Tryptophan Residues on the Greek Key Motifs of βB2-Crystallin
(9th International Conference on the Lens 2023)

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Education (3)：

2003 - 2006 京都大学理学研究科化学専攻博士後期課程
2001 - 2003 京都大学理学研究科化学専攻博士前期課程
1997 - 2001 Ritsumeikan University College of Science and Engineering Department of Applied Chemistry

Professional career (1)：

理学博士 (京都大学)

Work history (10)：

2025/03 - 現在 Kyoto University Kyoto University Institute for Integrated Radiation and Nuclear Science
2021/04 - 現在 JST創発的研究支援事業
2020/04 - 2025/02 Kyoto University Kyoto University Institute for Integrated Radiation and Nuclear Science
2018/04 - 2020/03 Kyoto University Institute for Integrated Radiation and Nuclear Science
2017/04 - 2018/03 Kyoto University Research Reactor Institute, Division of Radiation Life Science

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Committee career (4)：

2021/12 - 現在 D-アミノ酸学会運営委員
2019/07 - 現在日本白内障学会評議員
2018/08 - 現在日本白内障学会編集委員
2018 - 現在水晶体研究会世話人

Awards (6)：

2017/11 - International Conference of Lens 2017 Travel Award
2017/05 - 日本白内障学会第29回日本白内障学会学術賞
2016/06 - 日本皮膚科学会第115回日本皮膚科学会優秀ポスター賞
2015/12 - International Conference of Lens 2015 Travel Award
2015/08 - D-アミノ酸学会奨励賞

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Association Membership(s) (6)：

水晶体研究会 , International Society of Eye Research , Association for Research in Vision and Ophthalmology , THE JAPANESE SOCIETY FOR CATARACT RESEARCH , THE JAPANESE BIOCHEMICAL SOCIETY , D-AMINO ACID RESEARCH SOCIETY

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