Makiyama Takeru

Research field (1)： Cardiology

Research theme for competitive and other funds (15)：

2021 - 2026 臨床予後予測に向けたiPS細胞由来心筋症モデルによる特発性拡張型心筋症の病態解明
2022 - 2025 バイオインフォマティクスを用いた非コードDNA解析による若年突然死の発症機序解明
2021 - 2024 The elucidation of complicated genetic backgrounds and pathogenicity in patients with inherited primary arrhythmia syndromes caused by unknown etiology
2020 - 2023 Elucidation of molecular pathogenesis for inherited lethal arrhythmia associated with transporter abnormalities
2019 - 2022 Elucidation of the pathogenesis of lethal inherited arrhythmias using iPS cells and development of therapeutic approaches

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Papers (269)：

Makiyama Takeru, Gao Jingshan, Yamamoto Yuta, Kobayashi Takuya, Takanori Aizawa, Huang Hai, Kasahiwa Asami, Imamura Tomohiko, Aoki Hisaaki, Kato Koichi, et al. 心疾患の発症機構解明と新たな治療戦略 iPS細胞を用いたカルモジュリン遺伝子異常による致死性不整脈疾患の病態解明(Elucidation of the pathogenesis of heart diseases and development of new therapeutic strategies Modeling calmodulin-related life-threatening arrhythmias using iPS cells). The Journal of Physiological Sciences. 2024. 74. Suppl.2. 99-99
Manon Baudic, Hiroshige Murata, Fernanda M. Bosada, Uirá Souto Melo, Takanori Aizawa, Pierre Lindenbaum, Lieve E. van der Maarel, Amaury Guedon, Estelle Baron, Enora Fremy, et al. TAD boundary deletion causes PITX2-related cardiac electrical and structural defects. Nature Communications. 2024. 15. 1
Aizawa Takanori, Makiyama Takeru, Huang Hai, Imamura Tomohiko, Fukuyama Megumi, Sonoda Keiko, Kato Koichi, Ohno Seiko, Horie Minoru, Ono Koh. Fatal Arrhythmic Events are Higher in Non-missense than in Missense Variants in SCN5A-positive Brugada Syndrome(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. FRS5-3
Huang Hai, Makiyama Takeru, Shirai Manabu, Wakabayashi Masaki, Yoshida Morikatsu, Nishiuchi Suguru, Moriuchi Kenji, Gao Jing Shan, Kashiwa Asami, Imamura Tomohiko, et al. Histological Characteristics of a Rat Model of Cardiac Laminopathy Carrying Lmna p.S143P(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PE61-4
Asami Kashiwa, Hideki Itoh, Takeru Makiyama, Yuko Wada, Junichi Ozawa, Koichi Kato, Megumi Fukuyama, Tadashi Nakajima, Seiko Ohno, Minoru Horie. Clinical characterization of type 1 long QT syndrome caused by C-terminus Kv7.1 variants. Heart rhythm. 2024

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MISC (462)：

大野美紀子, 松浦博, 西清人, 糀谷泰彦, 牧山武, 池田真也, 西英一郎. M16メタロエンドペプチダーゼによる心拍数制御機構. 日本循環薬理学会口演要旨集. 2024. 33rd
三谷孟司, 三谷孟司, 糀谷泰彦, 糀谷泰彦, 岡本有司, 相澤卓範, 牧山武, 牧山武, 大野聖子, 堀江稔, et al. Development of Deep-Generative Models with Fine-tuning Techniques for Genetic Risk Prediction and Prognosis Stratification of Hereditary Arrhythmic Disease. 日本循環器学会学術集会(Web). 2024. 88th
井上智之, 喜多村恭平, 羽賀博典, 森永晃史, 米田史哉, 西脇修司, 田中宗和, 糀谷泰彦, 牧山武, 尾野亘, et al. 持続性心房細動に対するアブレーション中に大量の右左シャントによる低酸素血症で救命困難となった不整脈原性右室心筋症の1例. 日本心臓病学会学術集会(Web). 2023. 71st
KOHJITANI Hirohiko, KOHJITANI Hirohiko, MITANI Takeshi, OKAMOTO Yuji, AIZAWA Takanori, MAKIYAMA Takeru, MAKIYAMA Takeru, KASHIWA Asami, IMAMURA Tomohiko, OHNO Seiko, et al. Development of Precise Genetic Prognostic Model for Hereditary Arrhythmia Disease Using Machine Learning. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2022. 68th
KASHIWA Asami, MAKIYAMA Takeru, WADA Yuko, OZAWA Junichi, AIZAWA Takanori, IMAMURA Tomohiko, HUANG Hai, GAO Jingshan, KOHJITANI Hirohiko, OHNO Seiko, et al. Arrhythmic Risk is NOT Homogeneous in C-Terminal KCNQ1 Variants of Long QT Syndrome. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2022. 68th

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Patents (3)：

Books (3)：

変化と環境 : テクノロジーは何を変えるのか
産業能率短期大学出版部 1970
技術と変化 : テクノロジーの波及効果
産業能率短期大学出版部 1970
研究開発プロジェクト : その評価と管理
日本能率協会 1969

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