ARAI Eri

アライエリ | ARAI Eri

Affiliation and department：
Job title： Associate Professor
Other affiliations (1)：

国立研究開発法人国立がん研究センター研究所客員主任研究員

Homepage URL (1)： https://pathology.med.keio.ac.jp/

Research field (2)： Experimental pathology , Human pathology

Research keywords (29)： DNAメチル化 , 前がん状態 , 腎がん , 分子病理 , 多段階発がん , 肝細胞がん , 腫瘍 , ウイルス性肝炎 , 尿路上皮がん , 炎症 , 腎細胞がん , BACアレイ , 非アルコール性脂肪肝 , 分子病理学 , 慢性炎症 , アルコール性肝炎 , 発がんリスク , 予後予測 , 発がんリスク評価 , DNMT1 , BAMCA法 , 肺がん , 慢性閉塞性肺疾患 , DNAメチルトランスフェラーゼ , 慢性肝炎 , ヒストンメチルトランスフェラーゼ , ヒストン修飾 , ヒストンアセチルトランスフェラーゼ , 肝がん

Research theme for competitive and other funds (13)：

2023 - 2028 尿路上皮がんに対する新規エピゲノム解析による治療効果予測バイオマーカー開発
2022 - 2025 Molecular aberrations of micropapillary architecture leading to malignant trait formation in cancer
2021 - 2024 Pathological diagnosis based on integration of morphological images and multi-layer omics data by artificial intelligence
2019 - 2023 Development of personalized therapy for patients with CpG island methylator phenotype renal cell carcinoma
2019 - 2022 Epigenomic regulation during development of testicular germ cell tumor

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Papers (90)：

河原徹, 藤本真央, 下田将之, 淺村尚生, 金井弥栄, 新井恵吏. 肺腺がんのDNAメチル化プロファイルに対する腫瘍微小環境の影響(Tumor microenvironment impacts genome-wide DNA methylation profiles of lung adenocarcinomas). 日本病理学会会誌. 2024. 113. 1. 367-367
Satomi Makiuchi, Ying Tian, Mao Fujimoto, Junko Kuramoto, Noboru Tsuda, Hidenori Ojima, Masahiro Gotoh, Nobuyoshi Hiraoka, Teruhiko Yoshida, Yae Kanai, et al. DNA methylation alterations of ADCY5, MICAL2, and PLEKHG2 during the developmental stage of cryptogenic hepatocellular carcinoma. Hepatology Research. 2023. 54. 3. 284-299
河原徹, 藤本真央, 下田将之, 淺村尚生, 金井弥栄, 新井恵吏. 肺腺がんのDNAメチル化プロファイルに対する免疫微小環境の影響. 日本病理学会会誌. 2023. 112. 1. 329-329
Junko Kuramoto, Eri Arai, Mao Fujimoto, Ying Tian, Yuriko Yamada, Takuya Yotani, Satomi Makiuchi, Noboru Tsuda, Hidenori Ojima, Moto Fukai, et al. Quantification of DNA methylation for carcinogenic risk estimation in patients with non-alcoholic steatohepatitis. Clinical epigenetics. 2022. 14. 1. 168-168
Hideki Ohmomo, Shohei Komaki, Yoichi Sutoh, Tsuyoshi Hachiya, Kanako Ono, Eri Arai, Hiroyuki Fujimoto, Teruhiko Yoshida, Yae Kanai, Koichi Asahi, et al. Potential DNA methylation biomarkers for the detection of clear cell renal cell carcinoma identified by a whole blood-based epigenome-wide association study. Epigenetics Communications. 2022. 2. 1

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MISC (27)：

北爪賀子, 新井恵吏, 松田厚志, 角田修一, 尾原健太郎, 前島亜希子, 久野敦, 吉田輝彦, 金井弥栄. 腎発がん過程におけるタンパク質の糖鎖修飾変化(Alteration of protein glycosylation in renal carcinogenesis). 日本癌学会総会記事. 2019. 78回. P-3075
Masahiro Gotoh, Eri Arai, Akio Matsuda, Hiroyuki Fujimoto, Kenji Matsumoto, Yae Kanai. Reduced expression of microRNA-200 family associated with aggressiveness and poorer patient outcome of clear cell renal cell carcinomas. CANCER RESEARCH. 2016. 76
Novel therapeutic target, prognostic indicator and companion diagnostic marker arising from integrative omics of renal cell carcinoma. 2015. 255. 6. 615-621
新井恵吏, 三浦史仁, 十時泰, 山下聡, 田迎, 後藤政広, 尾島英知, 中村浩実, 濱奈津子, 鈴木穣, et al. 国際ヒトエピゲノムコンソーシアム(IHEC)における日本人正常肝細胞の標準エピゲノムプロファイル解析. 日本癌学会総会記事. 2015. 74回. E-1157
Takashi Sato, Kenzo Soejima, Eri Arai, Junko Hamamoto, Hiroyuki Yasuda, Daisuke Arai, Kota Ishioka, Keiko Ohgino, Katsuhiko Naoki, Takashi Kohno, et al. PTPRH Hypomethylation as a Prognostic Factor in Non-Small Cell Lung Cancer. JOURNAL OF THORACIC ONCOLOGY. 2015. 10. 9. S722-S722

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Professional career (1)：

博士(医学)

Work history (10)：

2021/04 - 現在 Keio University School of Medicine Department of Pathology Associate Professor
2015/08 - 現在 National Cancer Center Research Institute Fundamental Innovative Oncology Core, FIOC Visiting fellow
2015/08 - 2021/03 Keio University School of Medicine Department of Pathology Assistant professor
2014/04 - 2015/07 National Cancer Center Research Institute Division of Molecular Pathology Senior scientist
2011/04 - 2015/07 National Cancer Center Hospital Department of Pathology and Clinical Laboratories

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