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J-GLOBAL ID：201601011762460322 Update date: Feb. 03, 2025

Watanabe Sachiko

ワタナベサチコ | Watanabe Sachiko

Affiliation and department：
Homepage URL (1)： https://kaken.nii.ac.jp/ja/search/?qm=80770619

Research field (1)： Immunology

Research theme for competitive and other funds (10)：

2019 - 2022 Mechanism of NLRP3 inflammasome in CAWS-induced vasculitis
2018 - 2022 Role of ARIH2 in the inflammasome-related cardiovascular disease
2018 - 2022 Neutrophils in inflammatory response induced by lipid crystals
2017 - 2021 Study of the role of the immunoproteasome in glucose- or lipid-metabolism
2018 - 2020 ASC contributes to thrombus formation independent of NLRP3

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Papers (27)：

Kosuke Zenke, Rino Sugimoto, Sachiko Watanabe, Masashi Muroi. NF-κB p105-mediated nuclear translocation of ERK is required for full activation of IFNγ-induced iNOS expression. Cellular signalling. 2024. 124. 111424-111424
Sachiko Watanabe, Kosuke Zenke, Masashi Muroi. Lipoteichoic Acid Inhibits Lipopolysaccharide-Induced TLR4 Signaling by Forming an Inactive TLR4/MD-2 Complex Dimer. The Journal of Immunology. 2023
Sachiko Watanabe, Kosuke Zenke, Yuka Sugiura, Masashi Muroi. Minimal structure of IRAK-1 to induce degradation of TRAF6. Immunobiology. 2022. 227. 5. 152256-152256
Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Emi Aizawa, Yoshiko Mizushina, Sachiko Watanabe, Chintogtokh Baatarjav, Takayoshi Matsumura, Masafumi Takahashi. Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome. eLife. 2022. 11
Sachiko Watanabe, Fumitake Usui-Kawanishi, Takanori Komada, Tadayoshi Karasawa, Ryo Kamata, Naoya Yamada, Hiroaki Kimura, Katsuya Dezaki, Tsukasa Ohmori, Masafumi Takahashi. ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome. Biochemical and biophysical research communications. 2020. 531. 2. 125-132

MISC (6)：

善家孝介, 善家孝介, 瀬田玲奈, 辻悠人, 渡邊幸子, 渡邊幸子, 室井正志, 室井正志. Regualtion of TRIF-dependent TLR sginaling by PPM family phosphatases. 日本薬学会年会要旨集(Web). 2024. 144th
渡邊幸子, 渡邊幸子, 寺牛あゆみ, 古川憂菜, 善家孝介, 善家孝介, 室井正志, 室井正志. STAT1 N-terminal domain is required for the formation of parallel dimeric structure of activated STAT1. 日本薬学会年会要旨集(Web). 2024. 144th
善家孝介, 善家孝介, 杉本梨乃, 渡邊幸子, 渡邊幸子, 室井正志, 室井正志. NF-κB p105 is necessary for IFNγ-induced iNOS expression. 日本薬学会年会要旨集(Web). 2023. 143rd
渡邊幸子, 渡邊幸子, 善家孝介, 善家孝介, 室井正志, 室井正志. Lipoteichoic acid inhibits TLR4 signaling by forming an inactive TLR4/MD-2 complex dimer under serum-free conditions. 日本薬学会年会要旨集(Web). 2023. 143rd
渡邊幸子, 善家孝介, 室井正志. Lipoteichoic acidはTLR4/MD-2複合体の非活性化型二量体を形成することでTLR4シグナリングを抑制する. 日本エンドトキシン・自然免疫研究会プログラム・抄録集. 2022. 27th (Web)

Education (1)：

Professional career (1)：

Work history (3)：

2021/04 - 現在 Musashino University Faculty of Pharmacy Department of Pharmaceutical Sciences
2016/03 - 2019/09 Jichi Medical University
- 2016/02 Kyoto University

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