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J-GLOBAL ID：201601014636233760 Update date: Mar. 25, 2025

Matsushita Hirokazu

マツシタヒロカズ | Matsushita Hirokazu

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Affiliation and department：
Job title： Chief
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/80597782.ja.html

Research field (5)： Digestive surgery , Respiratory surgery , Cardiovascular surgery , Urology , Tumor diagnostics and therapeutics

Research keywords (30)：変異ペプチド , ミスセンス変異 , 次世代シーケンス , 固有抗原 , 全エクソームシーケンス , 全RNAシーケンス , 腎がん , MHC class I 結合予測法 , γδT細胞 , エクソームシーケンス , 胃がん , ワクチン治療 , 化学療法 , 膵癌 , 免疫反応 , 腎細胞癌 , 免疫細胞治療 , メッセンジャーRNA(mRNA) , 肺癌 , 肺がん , CAR , Chimeric Antigen Receptor(CAR) , 細胞傷害性T細胞 , 樹状細胞療法 , 有害事象 , HSP105 , MHC binding prediction法 , 免疫学的評価 , メッセンジャーRNA , 樹状細胞ワクチン治療

Research theme for competitive and other funds (31)：

2024 - 2027 転移性肺腫瘍の免疫学的微小環境の解析および遺伝子相互作用とネオアンチゲン探索
2024 - 2027 Development of personalized neoantigen immunotherapy for glioblastome using patient-derived organoids
2022 - 2025 The determination of T-cell fate by different tumor antigens and prevention of post-operative recurrence of lung cancer
2022 - 2025 The determination of T-cell fate by different tumor antigens and prevention of post-operative recurrence of lung cancer
2022 - 2025 Identification of resistant mechanisms of tumor cells against CAR-T cell-mediated cytotoxicity

2021 - 2025 Ready-tp-Use RNA-drug discovery for the acceleration of personalized cancer vaccine

2021 - 2025 簡易モニタリングのための好酸球を用いた頭頸部がん免疫治療バイオマーカーの開発

2021 - 2023 免疫一細胞データ解析による改変型T細胞受容体デザイン技術の開発

2020 - 2023 個別化がんワクチン療法に向けた統合プロテオミクスによる新規がん抗原同定法の開発

2020 - 2023 末梢血中循環腫瘍細胞を用いた非小細胞肺癌への化学療法による免疫原性細胞死の解析

2020 - 2023 In-depth surfaceome analysis of PDX models to develop innovative personalized therapies in pancreatic cancer

2019 - 2023 卵巣癌の個別化治療を目指した免疫プロファイルに基づく包括的バイオマーカーの開発

2019 - 2022 Specific immune responses against tumor antigens in long term survivors of cancer

2017 - 2020 Analysis of intratumoral immune response in head and neck cancer for optimal combination immunotherapy

2017 - 2020 Comprehensive profiling of tumor immune microenvironment for effective personalized lung cancer vaccine

2017 - 2020 Analysis of intratumoral immune response in gastric and esophageal cancer for optimal combination immunotherapy

2016 - 2020 Integrative analysis of lineage-survival signaling in lung adenocarcinoma

2016 - 2019 Neoantigen and local immune profile in ovarian clear cell carcinoma

2016 - 2019 Development of cancer immunotherapy targeting mutation-derived neoantigens

2016 - 2019 Novel cancer immunotherapy targeting neoantigens in combination with epigenetics and immune modulation

2015 - 2019 Analysis of intra-tumor immune response toward development of autologous gamma-delta T-cell transfer therapy in patients with advanced urothelial carcinoma

2015 - 2018 Development of personalized lung cancer vaccine targeting neoantigens

2015 - 2017 Detection of neoantigens by gene-engineered T cells

2014 - 2017 Identification of neoantigens and development of a novel personalized lung cancer treatment targeting passenger mutations

2013 - 2016 DC-based vaccination combined with interferon for metastatic renal cell carcinoma

2013 - 2016 Mutanome analyses by next generation sequencing and individualized cancer vaccine development in gastric cancer

2013 - 2016 Identification of unique antigens by next generation sequencing and development of individualized cancer immunotherapy in clear cell renal cell carcinoma

2012 - 2016 Chimeric antigen receptor gamma delta T cell immunotherapy for the treatment of malignant mesothelioma

2012 - 2015 Development of cancer vaccine therapy targeting individual genetic mutations identified by next generation sequencing

2012 - 2015 Reverse Translational Research for Understanding immune response in the Tumor and Identification of Biomarkers

2011 - 2013 Vaccination therapy combined with chemotherapy for recurrent pancreatic cancer patients

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Papers (112)：

Takanari Okamoto, Ryo Mizuta, Ayako Demachi-Okamura, Daisuke Muraoka, Eiichi Sasaki, Katsuhiro Masago, Rui Yamaguchi, Satoshi Teramukai, Yoshihiro Otani, Isao Date, et al. Immune prognostic model for glioblastoma based on the ssGSEA enrichment score. Cancer genetics. 2025. 294-295. 32-41
Eiichi Sasaki, Yasuko Fujita, Katsuhiro Masago, Akari Iwakoshi, Nobuhiro Hanai, Hirokazu Matsushita. S100-positive stroma in salivary gland basal cell adenomas: a neoplastic component with CTNNB1 mutations. Virchows Archiv : an international journal of pathology. 2024
Aiko Ogasawara, Hirokazu Matsushita, Tuan Zea Tan, Daisuke Shintani, Jieru Ye, Shoji Nagao, Ayako Demachi-Okamura, Daisuke Muraoka, Yukari Kobayashi, Kazuhiro Kakimi, et al. Immunological impact of intraperitoneal and intravenous chemotherapy in ovarian cancer, translational analyses of the Phase 3 iPocc trial. Gynecologic oncology. 2024. 191. 124-131
Yosuke Chiba, Tomomitsu Doi, Kunie Obayashi, Kazuhiro Sumida, Shohei Nagasaka, Ke-Yong Wang, Kei Yamasaki, Katsuhiro Masago, Hirokazu Matsushita, Hiroaki Kuroda, et al. Caspase-4 promotes metastasis and interferon-γ-induced pyroptosis in lung adenocarcinoma. Communications biology. 2024. 7. 1. 699-699
Eiichi Sasaki, Katsuhiro Masago, Hirokazu Matsushita. Are Solitary Fibrous Tumors of the Pancreas the Same Tumor as Pancreatic Hamartomas?. The American journal of surgical pathology. 2024

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MISC (61)：

長谷川幸清, 松下博和, 織田克利, 山本尚吾, 浅田佳代, 西島明, 唐崎隆弘, 池田悠至, 藤原恵一, 油谷浩幸, et al. 卵巣漿液性癌におけるDNA相同組換え修復、ネオアンチゲンおよび局所免疫の関連(A subgroup with a T-cell inflamed phenotype in homologous recombination proficient high-grade serous ovarian carcinoma). 日本癌学会総会記事. 2018. 77回. 1149-1149
根城尭英, 松下博和, 野村昌志, 田中將太, 永江玄太, 成田善孝, 永根基雄, 西川亮, 植木敬介, 油谷浩幸, et al. 神経膠腫におけるネオアンチゲンと免疫微小環境の経時変化に関するマルチオミクス解析(Integrated Omics Analysis on Temporal Changes of Neoantigen and Tumor Microenvironment in Primary and Recurrent Gliomas). 日本癌学会総会記事. 2018. 77回. 1778-1778
松下博和, 垣見和宏. ネオ抗原同定と免疫治療への応用次世代シーケンサーを活用したネオアンチゲンと抗腫瘍免疫応答の解析. 日本がん免疫学会総会プログラム・抄録集. 2018. 22回. 45-45
根城尭英, 松下博和, 唐崎隆弘, 野村昌志, 永江玄太, 高柳俊作, 田中將太, 成田善孝, 永根基雄, 西川亮, et al. 神経膠腫におけるネオアンチゲンと免疫微小環境の経時変化に関するマルチオミクス解析. 日本がん免疫学会総会プログラム・抄録集. 2018. 22回. 84-84
長岡孝治, 唐崎隆弘, 長山和弘, 中島淳, 松下博和, 垣見和宏. 免疫チェックポイント阻害剤治療によるイムノグラムの変動. 日本がん免疫学会総会プログラム・抄録集. 2018. 22回. 87-87

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Work history (1)：

2013 - The University of Tokyo

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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