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J-GLOBAL ID：201601015087490441   Update date: Apr. 15, 2025

白神 宜史

白神 宜史 | 白神 宜史
Affiliation and department：
Osaka University

About Osaka University


Other affiliations (2)：
Research field  (1)： Pharmaceuticals - chemistry and drug development
Research keywords  (5)： radiochemistry ,  targeted alpha therapy ,  radiopharmaceuticals ,  nuclear medicine ,  theranostics
Research theme for competitive and other funds  (6)：
  • 2024 - 2027 Development of innovative alpha therapy targeting cancer-associated fibroblasts
  • 2021 - 2024 アルファ線を用いた切らない日帰りがん治療への挑戦
  • 2020 - 2023 Targeted alpha therapy for patients with tumor
  • 2019 - 2022 Development of Nuclear Medicine Therapy targeting Cancer Stroma
  • 2018 - 2020 アミノ酸トランスポーターLAT1を標的とするα線がんミサイル療法の開発
Show all
Papers (63)：
  • Tadashi Watabe, Takumi Iwasawa, Hiroyuki Kimura, Yoshifumi Shirakami, Sadahiro Naka, Kazuko Kaneda, Takanori Kobayashi, Marina Omokawa, Yusuke Yagi, Noriyuki Tomiyama, et al. Theranostics using 89Zr/177Lu-labeled antibody targeting erythropoietin-producing hepatocellular A2 (EphA2). European Journal of Nuclear Medicine and Molecular Imaging. 2025
  • Tadashi Watabe, Koji Hatano, Sadahiro Naka, Hidetaka Sasaki, Takashi Kamiya, Yoshifumi Shirakami, Atsushi Toyoshima, Jens Cardinale, Frederik L Giesel, Kayako Isohashi, et al. First-in-human SPECT/CT imaging of [211At]PSMA-5: targeted alpha therapy in a patient with refractory prostate cancer. European journal of nuclear medicine and molecular imaging. 2024
  • Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Kentaro Hisada, Sifan Feng, Yuichiro Kadonaga, Kazuhiro Ooe, Tadashi Watabe, Yoshiyuki Manabe, Atsushi Shimoyama, Masashi Murakami, et al. Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-211. International Journal of Molecular Sciences. 2024
  • Kentaro Hisada, Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Atsuko Saito, Tadashi Watabe, Sifan Feng, Kazuhiro Ooe, Xiaojie Yin, Hiromitsu Haba, et al. Comparison Length of Linker in Compound for Nuclear Medicine Targeting Fibroblast Activation Protein as Molecular Target. International Journal of Molecular Sciences. 2024
  • Kaori Abe, Tadashi Watabe, Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Sadahiro Naka, Kazuhiro Ooe, Atsushi Toyoshima, Frederik Giesel, Takeshi Usui, et al. Evaluation of Targeted Alpha Therapy Using [211At]FAPI1 in Triple-Negative Breast Cancer Xenograft Models. International Journal of Molecular Sciences. 2024
ｍore...
MISC (32)：
  • 白神宜史. RIの利用と核医学への応用. ELPH Symposium 2024. ELPH Symposium 2024. 2024
  • 兼田(中島) 加珠子, 樺山 一哉, 白神 宜史, 渡部 直史, 豊嶋 厚史, 深瀬 浩一. 進行がんや手術困難例に対する核医学治療薬の現状と新規治療薬の開発-Development of nuclear medicine for targeting alpha therapy to cancer. 臨床免疫・アレルギー科 = Clinical immunology & allergology / 臨床免疫・アレルギー科編集委員会 編. 2023. 79. 3. 348-352
  • Kabayama Kazuya, Shirakami Yoshifumi, Kaneda Kazuko, Watabe Tadashi, Toyoshima Atsushi. Activities of Targeted Alpha Therapy at Osaka University. MEDCHEM NEWS. 2022. 32. 2. 93-98
  • Zihao Qiu, Yoshifumi Shirakami, Kazuko Kaneda, Yuichiro Kadonaga, Kazuhiro Ooe, Atsushi Toyoshima, Atsushi Shinohara, Koichi Fukase. Synthetic study of At-211 labeled cancer targeting amino acids,. 2021
  • 渡部 直史, 兼田 加珠子, 白神 宜史, 大江 一弘, 豊嶋 厚史, 篠原 厚. アスタチンを用いた難治性甲状腺がんに対するアルファ線核医学治療. アイソトープ・放射線研究発表会. 2021. 1. 67
ｍore...
Patents (7)：
  • アスタチン溶液及びその製造方法
  • 放射標識されたアリール化合物の製造方法
  • アスタチン溶液およびその製造方法
  • 放射標識されたFAPIα親和性化合物およびその用途
  • 放射標識された化合物及びその用途
ｍore...
Books (2)：
  • NAS/COMMENTARIES:No.27
    2023
  • Iodine chemistry and applications
    Wiley & Sons Inc 2014
Lectures and oral presentations  (59)：
  • 医師主導治験に向けた[211At]PSMA-5注射液のプロセスバリデーション
    (第64回日本核医学 2024)
  • 前立腺がん治療薬[211At]PSMA-5及び[225Ac]PSMA-617の前臨床における性能比較.
    (第64回日本核医学会学術総会 2024)
  • SYNTHESIS AND EVALUATION OF ASTATINE-211-LABELED AGENT TARGETING FIBROBLAST ACTIVATION PROTEIN IN CANCER.
    (2024)
  • Absorbed dose estimation of [211At]PSMA-5 using a novel semiconductor imaging system in a preclinical study.
    (EANM2024 2024)
  • Analysis of eluates toward standardization of 211At quality (2) HPLC analysis of 211At aqueous solutions
    (2024)
ｍore...
Professional career (1)：
  • 理学博士 (東北大学)
Work history (6)：
  • 2022/04 - 現在 Osaka University Forefront Research Center, Graduate School of Science Specially Appointed Associated Professor
  • 2019/04 - 現在 Osaka University Institute for Radiation Sciences Specially appointed Associate Professor
  • 2021/04 - 2022/03 Osaka University
  • 2020/04 - 2021/03 Osaka University Research Center for Nuclear Physics
  • 2015/06 - 2019/03 Osaka University Graduate School of Medicine Nuclear Medicine and Tracer Kinetics Specially Appointed Associate Professor
Show all
Association Membership(s) (2)：
JAPAN RADIOLOGICAL SOCIETY ,  JAPANESE SOCIETY OF NUCLEAR MEDICINE
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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