白神宜史

白神宜史 | 白神宜史

Affiliation and department：
Other affiliations (2)：

Osaka University Research Center for Nuclear Physics
Osaka University

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (5)： radiochemistry , targeted alpha therapy , radiopharmaceuticals , nuclear medicine , theranostics

Research theme for competitive and other funds (6)：

2024 - 2027 Development of innovative alpha therapy targeting cancer-associated fibroblasts
2021 - 2024 アルファ線を用いた切らない日帰りがん治療への挑戦
2020 - 2023 Targeted alpha therapy for patients with tumor
2019 - 2022 Development of Nuclear Medicine Therapy targeting Cancer Stroma
2018 - 2020 アミノ酸トランスポーターLAT1を標的とするα線がんミサイル療法の開発

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Papers (62)：

Tadashi Watabe, Koji Hatano, Sadahiro Naka, Hidetaka Sasaki, Takashi Kamiya, Yoshifumi Shirakami, Atsushi Toyoshima, Jens Cardinale, Frederik L Giesel, Kayako Isohashi, et al. First-in-human SPECT/CT imaging of [211At]PSMA-5: targeted alpha therapy in a patient with refractory prostate cancer. European journal of nuclear medicine and molecular imaging. 2024
Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Kentaro Hisada, Sifan Feng, Yuichiro Kadonaga, Kazuhiro Ooe, Tadashi Watabe, Yoshiyuki Manabe, Atsushi Shimoyama, Masashi Murakami, et al. Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-211. International Journal of Molecular Sciences. 2024
Kentaro Hisada, Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Atsuko Saito, Tadashi Watabe, Sifan Feng, Kazuhiro Ooe, Xiaojie Yin, Hiromitsu Haba, et al. Comparison Length of Linker in Compound for Nuclear Medicine Targeting Fibroblast Activation Protein as Molecular Target. International Journal of Molecular Sciences. 2024
Kaori Abe, Tadashi Watabe, Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Sadahiro Naka, Kazuhiro Ooe, Atsushi Toyoshima, Frederik Giesel, Takeshi Usui, et al. Evaluation of Targeted Alpha Therapy Using [211At]FAPI1 in Triple-Negative Breast Cancer Xenograft Models. International Journal of Molecular Sciences. 2024
Tadashi Watabe, Kazuko Kaneda-Nakashima, Yuichiro Kadonaga, Kazuhiro Ooe, Thosapol Sampunta, Naoki Hirose, Xiaojie Yin, Hiromitsu Haba, Yukiyoshi Kon, Atsushi Toyoshima, et al. Preclinical Evaluation of Biodistribution and Toxicity of [211At]PSMA-5 in Mice and Primates for the Targeted Alpha Therapy against Prostate Cancer. International journal of molecular sciences. 2024. 25. 11

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MISC (31)：

兼田(中島) 加珠子, 樺山一哉, 白神宜史, 渡部直史, 豊嶋厚史, 深瀬浩一. 進行がんや手術困難例に対する核医学治療薬の現状と新規治療薬の開発-Development of nuclear medicine for targeting alpha therapy to cancer. 臨床免疫・アレルギー科 = Clinical immunology & allergology / 臨床免疫・アレルギー科編集委員会編. 2023. 79. 3. 348-352
Kabayama Kazuya, Shirakami Yoshifumi, Kaneda Kazuko, Watabe Tadashi, Toyoshima Atsushi. Activities of Targeted Alpha Therapy at Osaka University. MEDCHEM NEWS. 2022. 32. 2. 93-98
Zihao Qiu, Yoshifumi Shirakami, Kazuko Kaneda, Yuichiro Kadonaga, Kazuhiro Ooe, Atsushi Toyoshima, Atsushi Shinohara, Koichi Fukase. Synthetic study of At-211 labeled cancer targeting amino acids,. 2021
渡部直史, 兼田加珠子, 白神宜史, 大江一弘, 豊嶋厚史, 篠原厚. アスタチンを用いた難治性甲状腺がんに対するアルファ線核医学治療. アイソトープ・放射線研究発表会. 2021. 1. 67
白神宜史, 白神宜史, 白神宜史, 兼田加珠子, 兼田加珠子, 渡部直史, 渡部直史, 大江一弘, 大江一弘, 角永悠一郎, et al. アスタト-脱ボロン酸反応による²¹¹At標識αメチルチロシンの製造と生物活性に関する研究. 核医学(Web). 2021. 58. Supplement

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Patents (7)：

アスタチン溶液及びその製造方法
放射標識されたアリール化合物の製造方法
アスタチン溶液およびその製造方法
放射標識されたFAPIα親和性化合物およびその用途
放射標識された化合物及びその用途

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Books (2)：

NAS/COMMENTARIES:No.27
2023
Iodine chemistry and applications
Wiley & Sons Inc 2014

Lectures and oral presentations (33)：

Synthesis and Preclinical Evaluation of 225Ac-PSMA-617 for Targeted Alpha Therapy in Mice with Prostate Cancer.
(IMR-Oarai & Oarai-Alpha Workshop 2022/09/28-30 2022)
. 211At標識PSMA誘導体による前立腺がんα線核医学治療
(第5回日本核医学会分科会放射性薬品科学研究会第21回放射性医薬品・画像診断薬研究会 2022)
核医学利用に向けたCe-141の加速器製造と分離精製の検討.
(日本放射化学会第66回討論会 2022.9.15-17(東京) 2022)
難治性甲状腺がんに対するアスタチンを用いた医師主導治験
(第59回アイソトープ・放射線研究発表会(オンライン、2022年7月6-8日) 2022)
がんの創薬研究:PET画像診断からα線核医学治療へ.
(ギルソン社ピペットマン生誕50周年記念研究フォーラム 2022)

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Professional career (1)：

理学博士 (東北大学)

Work history (6)：

2022/04 - 現在 Osaka University Forefront Research Center, Graduate School of Science Specially Appointed Associated Professor
2019/04 - 現在 Osaka University Institute for Radiation Sciences Specially appointed Associate Professor
2021/04 - 2022/03 Osaka University
2020/04 - 2021/03 Osaka University Research Center for Nuclear Physics
2015/06 - 2019/03 Osaka University Graduate School of Medicine Nuclear Medicine and Tracer Kinetics Specially Appointed Associate Professor

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Association Membership(s) (2)：

JAPAN RADIOLOGICAL SOCIETY , JAPANESE SOCIETY OF NUCLEAR MEDICINE

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白神 宜史

白神宜史