Rchr
J-GLOBAL ID:201801001538444850
Update date: Apr. 21, 2025 Kazuki Yasuhiro
カヅキ ヤスヒロ | Kazuki Yasuhiro
Affiliation and department: Research field (1):
Laboratory animal science
Research keywords (1):
Chromosome engineering
Research theme for competitive and other funds (20): - 2024 - 2027 ゲノム編集誘導性分子多様化による、機能抗体・ペプチド表現型スクリーニングシステム
- 2023 - 2027 ゲノム編集誘導性分子多様化による、機能抗体・ペプチド表現型スクリーニングシステム
- 2023 - 2026 ヒト人工染色体ベクターによるデザイナーiCAR-T細胞創出プラットフォーム開発
- 2022 - 2025 染色体工学的アプローチによるクラインフェルター症候群の原因遺伝子同定
- 2022 - 2025 Development of a predictive mouse model for drug efficacy of IgG antibody therapeutics targeting cancer cells
- 2020 - 2023 Generation of humanized rats expressing multiple drug-metabolizing enzyme-related genes using mammalian artificial chromosome technologies
- 2019 - 2022 Development of induciblydiversified antibody-expressing cell library that enables antibody phenotypic screening
- 2017 - 2020 Production of genetically modified pigs by combined techniques of chromosome engineering and genome editing
- 2015 - 2020 Generation of humanized rats expressing drug-metabolizing enzyme using human artificial chromosome and genome editing technologies
- 2014 - 2017 Development of rapid system for generation of consomic mice via chromosome transfer and elimination technologies
- 2013 - 2016 Establishment of in vitro and in vivo models for human CES which promote rational development of ester-based prodrugs
- 2011 - 2013 Study for sex differences of CYP3A enzymes using trans-chromosomic mice containing a human CYP3A gene cluster
- 2009 - 2012 Creation of CYP3A- and P-glycoprotein-humanized mouse and its application to the study of drug metabolism and disposition
- 2010 - 2011 Development of the antibody drug production system using a highly efficient artificial chromosome vector.
- 2009 - 2011 Gene therapy of Duchenne muscular dystrophy using own stem cells and human artificial chromosome
- 2010 - 2010 iPS細胞とヒト人工染色体ベクターを用いた毛細血管拡張性運動失調症の遺伝子治療
- 2009 - 2010 スティーブンス・ジョーンソン症候群モデルマウス創製の試み
- 2007 - 2009 Generation of gene therapy method for ataxia-telangiectasia using a human artificial chromosome
- 2006 - 2008 Construction of human artificial chromosome for gene therapy of Duchenne muscular dystrophy
- 2003 - 2004 ヒト21番染色体移入によるダウン症候群モデルマウスの作製と解析
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Papers (168): -
Yuki Anraku, Shunsuke Kita, Taishi Onodera, Akihiko Sato, Takashi Tadokoro, Shiori Ito, Yu Adachi, Ryutaro Kotaki, Tateki Suzuki, Jiei Sasaki, et al. Structural and virological identification of neutralizing antibody footprint provides insights into therapeutic antibody design against SARS-CoV-2 variants. Communications biology. 2025. 8. 1. 483-483
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Yosuke Hiramuki, Miwa Hosokawa, Kayo Osawa, Taku Shirakawa, Yasuhiro Watanabe, Ritsuko Hanajima, Hiroyuki Kugoh, Hiroyuki Awano, Masafumi Matsuo, Yasuhiro Kazuki. Titin fragment is a sensitive biomarker in Duchenne muscular dystrophy model mice carrying full-length human dystrophin gene on human artificial chromosome. Scientific reports. 2025. 15. 1. 1778-1778
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Yayan Wang, Kanako Kazuki, Genki Hichiwa, Masaharu Hiratsuka, Ryohei Ogihara, Satoshi Abe, Haochen Tu, Yanze Li, Xu Gao, Mitsuo Oshimura, et al. Human artificial chromosome carrying R-spondin1 and IL-22 expression cassettes in rejuvenated MSCs enhances therapeutic efficacy in ulcerative colitis model mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024. 182. 117751-117751
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Narumi Uno, Hitomaru Miyamoto, Kyotaro Yamazaki, Masaya Egawa, Hiroaki Kobayashi, Kanako Kazuki, Mitsuhiko Osaki, Teruhiko Suzuki, Shusei Hamamichi, Mitsuo Oshimura, et al. Microcell-mediated chromosome transfer between non-identical human iPSCs. Molecular Therapy - Nucleic Acids. 2024. 35. 4. 102382-102382
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Kazuto Shimoya, Takashi Moriwaki, Kanako Kazuki, Akane Okada, Shigenori Baba, Yuana Masuda, Satoshi Abe, Yasuhiro Kazuki. Mice carrying the full-length human immunoglobulin loci produce antigen-specific human antibodies with the lambda light chain. iScience. 2024. 27. 12. 111258-111258
more... MISC (150): -
大関淳一郎, 山崎匡太郎, 久郷和人, 岡崎考映, 中野めぐみ, 大竹興一郎, 白澤健太, 磯部祥子, 遠藤祐介, 舛本寛, et al. 染色体工学技術応用(10):合成ヒトセントロメアから読み解く,CENP-A疎密領域の構造とエピジェネティックな制御機構. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th
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宇野愛海, 宮本人丸, 山崎匡太郎, 永川真也, 小林大晃, 鈴木輝彦, 濱道修生, 香月加奈子, 押村光雄, 冨塚一磨, et al. 染色体工学技術応用(3):ヒトiPS細胞からヒトiPS細胞への染色体導入法を用いた21番,X,Y染色体異数性細胞の作製と解析. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th
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小林大晃, 坂野仁美, 宮本人丸, 山崎匡太郎, 香月加奈子, 平塚正治, 平塚正治, 鈴木輝彦, 香月康宏, 香月康宏, et al. 染色体工学技術応用(1):密度勾配遠心法を利用した染色体導入技術の開発. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th
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宇野愛海, 宮本人丸, 山崎匡太郎, 永川真也, 鈴木輝彦, 濱道修生, 押村光雄, 冨塚一磨, 香月康宏, 香月康宏. ヒトiPS細胞からの微小核細胞融合法を用いた染色体異常症候群モデルヒトiPS細胞の開発. 日本再生医療学会総会(Web). 2024. 23rd
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濱道修生, 森脇崇史, 森脇崇史, 香月康宏, 香月康宏, 香月康宏. 医学用語解説 完全ヒト抗体産生動物を用いたヒト抗体作製. 炎症と免疫. 2024. 32. 3
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