Sayaka Sobue

ソブエサヤカ | Sayaka Sobue

Affiliation and department：

Research field (5)： Experimental pathology , Nutrition and health science , Other , Cell biology , Molecular biology

Research keywords (3)：酸化ストレス , ミトコンドリア , 分子状水素

Research theme for competitive and other funds (4)：

2018 - 2019 水素を用いた非アルコール性脂肪肝炎の病態制御及び発癌の新規予防法の確立
2014 - 2017 水素の経口投与を基盤とした非アルコール性脂肪肝炎の病態制御及び発癌の予防法の開発
2010 - 2013 トランスジェニックマウスを用いたCD109の機能解析および発癌機構の検討
2008 - 2010 赤白血病モデル細胞の分化および腫瘍化におけるスフィンゴシンキナーゼ1発現の関与

Papers (28)：

Chisato Inoue, Sayaka Sobue, Yuka Aoyama, Naoki Mizutani, Yoshiyuki Kawamoto, Yuji Nishizawa, Masatoshi Ichihara, Akihiro Abe, Fumihiko Hayakawa, Motoshi Suzuki, et al. BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells. Biochemistry and biophysics reports. 2018. 15. 69-75
Matsuoka H, Miyata S, Okumura N, Watanabe T, Hashimoto K, Nagahara M, Kato K, Sobue S, Takeda K, Ichihara M, et al. Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993). 2018. 1-5
Hiroshi Nishiwaki, Mikako Ito, Shuto Negishi, Sayaka Sobue, Masatoshi Ichihara, Kinji Ohno. Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles. Free Radical Research. 2018. 52. 4. 434-445
Sayaka Sobue, Chisato Inoue, Fumiko Hori, Shanlou Qiao, Takashi Murate, Masatoshi Ichihara. Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017. 493. 1. 318-324
Yuka Aoyama, Sayaka Sobue, Naoki Mizutani, Chisato Inoue, Yoshiyuki Kawamoto, Yuji Nishizawa, Masatoshi Ichihara, Mamoru Kyogashima, Motoshi Suzuki, Yoshinoti Nozawa, et al. Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017. 486. 2. 551-557

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Lectures and oral presentations (27)：

分子状水素はH3K27のメチル化状態を変化させ遺伝子発現を修飾しmtUPRを誘導する
(2017)
Molecular hydrogen activates the mitochondrial unfolded protein response via epigenetic histone modification and ameliorates ultraviolet light-induced damage in Caenorhabditis elegans
(8th World Congress on Targeting Mitochondria 2017 2017)
分子状水素はエピジェネティックに遺伝子発現を修飾するとともにmtUPRを誘導し生体を保護する
(第7 回日本分子状水素医学生物学会大会 2017)
分子状水素による肝障害軽減作用の背景にあるミトコンドリア保護効果に関与する分子機構の解析
(2016)
Molecular hydrogen is a novel antioxidant to reduce oxidative stress and attenuate disease progression through modification of cell signaling and gene expressions.
(15th International Conference on Oxidative Stress Reduction, Redox Homeostasis &Antioxidants 2015)

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Education (3)：

2005 - 2008 名古屋大学大学院医学系研究科医療技術学専攻博士後期課程
2003 - 2005 名古屋大学大学院医学系研究科医療技術学専攻博士前期課程
1999 - 2003 Nagoya University School of Medicine

Professional career (1)：

博士(医療技術学) (名古屋大学)

Work history (3)：

2016/09 - 現在 Chubu University College of Life and Health Sciences
2012/01 - 2016/08 Chubu University College of Life and Health Sciences
2008/04 - 2011/12 Chubu University Department of Biomedical Sciences, College of Life and Health Sciences

Association Membership(s) (3)：

日本分子状水素医学生物学会 , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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