Rchr
J-GLOBAL ID:201801006419658673   Update date: Feb. 01, 2024

Kasahara Yuko

Kasahara Yuko
Affiliation and department:
Research field  (2): Cell biology ,  Molecular biology
Research keywords  (4): 細胞治療 ,  モデル動物 ,  筋ジストロフィー ,  間葉系幹細胞
Research theme for competitive and other funds  (7):
  • 2022 - 2026 筋ジストロフィーに対する機能強化羊膜間葉系幹細胞を用いた抗炎症療法と評価系の構築
  • 2021 - 2024 羊膜間葉系幹細胞由来エクソソームを利用した次世代型脳梗塞治療法の確立
  • 2019 - 2022 Integrated understanding of dermatan sulfate through uncovering pathophysiology of musculocontractural Ehlers-Danlos syndrome
  • 2014 - 2017 Development of rAAV-mediated brain transduction with transient ultrasound-mediated modulation of the blood-brain interface in adult common marmoset toward modeling epilepsy
  • 2014 - 2017 Cell therapeutic approach using gene-transduced mesenchymal stromal cells for muscular dystrophy
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Papers (45):
  • Rimi Miyaoka, Yuji Tsunekawa, Yae Kurosawa, Takako Sasaki, Azusa Onodera, Kenji Sakamoto, Yuko Kakiuchi, Mikako Wada, Yuko Nitahara-Kasahara, Hiromi Hayashita-Kinoh, et al. Development of a novel purification method for AAV vectors using tangential flow filtration. Biotechnology and bioengineering. 2023
  • Masafumi Arakawa, Yuki Sakamoto, Yoshitaka Miyagawa, Chikako Nito, Shiro Takahashi, Yuko Nitahara-Kasahara, Satoshi Suda, Yoshiyuki Yamazaki, Mashito Sakai, Kazumi Kimura, et al. Induced pluripotent stem cell-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury via anti-inflammation and anti-oxidative stress in rats. Molecular Therapy - Methods & Clinical Development. 2023
  • Yuko Nitahara-Kasahara, Soya Nakayama, Koichi Kimura, Sho Yamaguchi, Yuko Kakiuchi, Chikako Nito, Masahiro Hayashi, Tomoyuki Nakaishi, Yasuyoshi Ueda, Takashi Okada. Immunomodulatory amnion-derived mesenchymal stromal cells preserve muscle function in a mouse model of Duchenne muscular dystrophy. Stem cell research & therapy. 2023. 14. 1. 108-108
  • Ayana Hashimoto, Takuya Hirose, Kohei Hashimoto, Shuji Mizumoto, Yuko Nitahara-Kasahara, Shota Saka, Takahiro Yoshizawa, Takashi Okada, Shuhei Yamada, Tomoki Kosho, et al. Collagen Network Formation in In Vitro Models of Musculocontractural Ehlers-Danlos Syndrome. Genes. 2023. 14. 2
  • 荒川 将史, 仁藤 智賀子, 宮川 世志幸, 坂本 悠記, 高橋 史郎, 笠原 優子, 須田 智, 酒井 真志人, 岡田 尚巳, 木村 和美. 一過性局所脳虚血モデルにおけるiPSC由来間葉系幹細胞(iMSC)の脳保護効果. 脳循環代謝. 2022. 34. 1. 114-114
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MISC (54):
  • 笠原 優子, 岡田 尚巳. 間葉系間質細胞による骨格筋を標的とした抗炎症療法. 別冊Bio Clinica: 慢性炎症と疾患. 2023. 12. 2. 112-116
  • Hiromi Hayashita-Kinoh, Posadas Herrera-Guillermo, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Shin'ichi Takeda, Takashi Okada. Development of Administration Protocols for Reduction of the Necessary Dose of rAAV for Treatment. MOLECULAR THERAPY. 2022. 30. 4. 494-494
  • Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Hiromi Hayashita-Kinoh, Shin'ichi Takeda, Takashi Okada. Anti-Inflammatory Properties of IL-10-Expressing Multipotent Mesenchymal Stromal Cells for Duchenne Muscular Dystrophy. MOLECULAR THERAPY. 2022. 30. 4. 490-490
  • 笠原優子, 中山宗哉, 木村公一, 山口翔, 垣内祐子, 仁藤智香子, 林真広, 中石智之, 上田恭義, 岡田尚巳. 羊膜間葉系幹細胞を用いた筋ジストロフィーに対する細胞治療. 日本筋学会学術集会プログラム・抄録集. 2022. 8th
  • Hiromi Hayashita-Kinoh, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Shin'ichi Takeda, Takashi Okada. Improved Transduction of DMD Dog with rAAV-Microdystrophin via Multipotent Mesenchymal Cell Pretreatment. MOLECULAR THERAPY. 2021. 29. 4. 287-288
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Patents (4):
Lectures and oral presentations  (6):
  • CRISPR/Cas9-mediated development and characterization of knockout mice for musculocontractural type Ehlers-Danlos Syndrome caused by mutations in CHST14 (mcEDS-CHST14).
    (Scientific meeting on the rarer types of Ehlers-Danlos Syndrome 2019)
  • Anti-inflammatory therapy using multipotent mesenchymal stromal cells for muscular dystrophy.
    (2019)
  • Efficiency of dental pulp-derived cell therapy for Duchenne muscular dystrophy treatment.
  • 歯髄幹細胞を用いた筋ジストロフィーに対する細胞治療
    (第17回日本再生医療学会 2018)
  • デルマタン4-O-硫酸基転移酵素-1欠損に基づくエーラスダンロス症候群モデルマウス作製と病態解析
    (2017年度生命科学系学会合同年次大会(ConBio2017))
more...
Work history (6):
  • 2024/01 - 現在 The University of Tokyo The Institute of Medical Science
  • 2021/08 - 2024/01 The University of Tokyo The Institute of Medical Science
  • 2015/10 - 2021/07 日本医科大学 生化学・分子生物学(分子遺伝学)
  • 2007/05 - 2015/09 National Center of Neurology and Psychiatry
  • 2005/04 - 2007/04 National Institute of Infectious Diseases
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Committee career (1):
  • 2018/07 - 現在 日本遺伝子細胞治療学会 評議員
Awards (3):
  • 2016 - 日本遺伝子細胞治療学会 第21回 日本遺伝子細胞治療学会 学術奨励賞
  • 2014 - 日本炎症・再生医学会 第35 回 日本炎症・再生医学会 優秀演題賞受賞
  • 2013 - 日本炎症・再生医学会 第34 回 日本炎症・再生医学会 優秀演題賞受賞
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