Koizumi Yukio

コイズミユキオ | Koizumi Yukio

Affiliation and department：

Research field (3)： Medical biochemistry , Bioorganic chemistry , Environmental and pharmaceutical development resources

Research theme for competitive and other funds (9)：

2022 - 2025 Exploration and evaluation of low molecular weight thrombolytic agents that induce endogenous uPA expression
2020 - 2021 秋田県内で分離した微生物由来の新規抗菌物質の開発
2014 - 2017 Analysis of molecular targets and development into drug discovery for cyclic peptides possessing thrombolysis-enhancing action
2012 - 2015 The availability of combination therapy using G2 checkpoint inhibitor against radiation-sensitive solid tumor
2011 - 2011 天然物由来の環状ペプチドを基盤とした新規血栓溶解剤の開発

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Papers (31)：

Yushi Nagaki, Satoru Motoyama, Tomokazu Yamaguchi, Midori Hoshizaki, Yusuke Sato, Teruki Sato, Yukio Koizumi, Akiyuki Wakita, Yuta Kawakita, Kazuhiro Imai, et al. m(6)A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis. GENES TO CELLS. 2020. 25. 8. 547-561
Yukio Koizumi, Jun Fukushima, Yayoi Kobayashi, Ayumi Kadowaki, Miyuki Natsui, Tomokazu Yamaguchi, Yumiko Imai, Toshihiro Sugiyama, Keiji Kuba. Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1. CHEMBIOCHEM. 2019. 20. 12. 1563-1568
Yukio Koizumi, Kenichiro Nagai, Lina Gao, Souichi Koyota, Tomokazu Yamaguchi, Miyuki Natsui, Yumiko Imai, Keiji Hasumi, Toshihiro Sugiyama, Keiji Kuba. Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity. SCIENTIFIC REPORTS. 2018. 8. 1. 5472-5472
Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, et al. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. SCIENCE SIGNALING. 2018. 11. 516
Yukio Koizumi, Kenichiro Nagai, Keiji Hasumi, Keiji Kuba, Toshihiro Sugiyama. Structure-activity relationship of cyclic pentapeptide malformins as fibrinolysis enhancers. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2016. 26. 21. 5267-5271

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MISC (25)：

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Patents (4)：

Awards (1)：

2018/09 - 日本農芸化学会東北支部日本農芸化学会東北支部奨励賞血栓溶解を賦活化させる微生物由来の環状ペプチドのケミカルバイオロジー研究

Association Membership(s) (5)：

日本血栓止血学会 , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , SOCIETY FOR ACTINOMYCETES JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

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