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J-GLOBAL ID:201801009703300230   Update date: Jan. 25, 2025

Itoh Hiroaki

イトウ ヒロアキ | Itoh Hiroaki
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Affiliation and department:
Homepage URL  (2): https://inoue.f.u-tokyo.ac.jp/index.htmlhttps://inoue.f.u-tokyo.ac.jp/e_index.html
Research field  (5): Chemical biology ,  Synthetic organic chemistry ,  Molecular biochemistry ,  Bioorganic chemistry ,  Pharmaceuticals - chemistry and drug development
Research keywords  (4): 生物有機化学 ,  biological activity ,  organic synthesis ,  natural products
Research theme for competitive and other funds  (7):
  • 2023 - 2028 天然物が織り成す化合物潜在空間が拓く生物活性分子デザイン
  • 2023 - 2028 異常アミノ酸含有天然物類縁体ライブラリー構築による化合物潜在空間探索
  • 2021 - 2024 固相ライブラリー戦略に基づくペプチド系天然物の精密構造制御と新機能創製
  • 2019 - 2021 ライブラリー戦略に基づく金属相互作用天然物の機能解明と新機能分子創製
  • 2017 - 2019 中・大型複雑構造ペプチド天然物の大規模構造活性相関による新規生物活性分子創出
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Papers (36):
  • Yuanqi Lin, Hiroaki Itoh, Shingo Dan, Masayuki Inoue. Methyl scanning approach for enhancing the biological activity of the linear peptidic natural product, efrapeptin C. Chemical Science. 2024
  • Junhao Fu, Yosuke Nakata, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Molecular Editing Enhances Oxidation Resistance of Menaquinone-Targeting Antibiotics Lysocin E and WAP-8294A2. Chemistry - A European Journal. 2023. e202301224
  • Yosuke Nakata, Junhao Fu, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives. Chemistry - A European Journal. 2023. e202301225
  • Yun-Wei Xue, Kensuke Miura, Hiroaki Itoh, Masayuki Inoue. C-Terminal modification of polytheonamide B uncouples its dual functions in MCF-7 cancer cells. Chemical Communications. 2023. 59. 26. 3914-3917
  • Hiroaki Itoh. Total Synthesis and Functional Analysis of Complex Peptidic Natural Products and Their Artificial Analogues. YAKUGAKU ZASSHI. 2022. 142. 6. 561-571
more...
Patents (26):
Books (6):
  • 実験医学増刊 Vol.43 No.2 中分子ペプチド医薬
    羊土社 2025 ISBN:9784758104241
  • New Tide of Natural Product Chemistry
    Springer 2023 ISBN:9789819917136
  • Preparation of Hindered Aniline CyanH and Application in the Allyl-Ni-Catalyzed α,β-Dehydrogenation of Carbonyls
    Organic Syntheses, Inc. 2021
  • Synthesis of 4-Nitrophenyl (2,2,6,6-Tetramethylpiperidin-1-yl) Carbonate (NPTC) for N-Protection of L-Phenylalanine Ethyl Ester
    Organic Syntheses, Inc. 2020
  • ライソシンEを基盤としたOBOCライブラリー構築と評価による新規抗菌類縁体の探索
    MEDCHEM NEWS 2020
more...
Professional career (1):
  • 博士(薬学) (東京大学)
Committee career (2):
  • 2017/04 - 現在 次世代を担う有機化学シンポジウム 世話人
  • 2021 - 2022 第20回次世代を担う有機化学シンポジウム実行委員
Awards (6):
  • 2024/10 - MSD生命科学財団 Chemist Award BCA 固相戦略が拓くペプチド系複雑天然物の全合成と機能応用への展開
  • 2022/07 - Asian Core Program / Advanced Research Network Lectureship Award (China)
  • 2021/07 - 天然物化学談話会 奨励賞 ペプチド系複雑天然物の固相全合成と類縁体群構築を基盤とした機能研究
  • 2021/03 - 日本薬学会 奨励賞 ペプチド系複雑天然物の全合成を基盤とした機能解明・新機能分子創出
  • 2019 - 日本薬学会医薬化学部会メディシナルケミストリーシンポジウム優秀賞(共同受賞)
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Association Membership(s) (4):
The Japanese Peptide Society ,  THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
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