Yasukawa Takashi

Affiliation and department：

Research field (1)： Molecular biology

Research theme for competitive and other funds (7)：

2021 - 2024 新規アルツハイマー病治療薬創出に向けたNRBP1-ユビキチンリガーゼ阻害剤の探索
2018 - 2021 Basic research for the development of therapeutic drugs for Alzheimer's disease targeting a novel ubiquitin ligase
2015 - 2018 Identification of target genes of transcription elongation factor Elongin A and analysis of its regulation
2012 - 2015 Role of transcription factor Elongin A with E3 activity in mouse neural development
2009 - 2011 Role of mammalian transcription elongation factor Elongin A in mouse neural development

Show all

Papers (30)：

Takashi Yasukawa, Aya Tsutsui, Chieri Tomomori-Sato, Shigeo Sato, Anita Saraf, Michael P Washburn, Laurence Florens, Tohru Terada, Kentaro Shimizu, Ronald C Conaway, et al. NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation. Cell reports. 2020. 30. 10. 3478-3491
Juston C. Weems, Brian D. Slaughter, Jay R. Unruh, Stefan Boeing, Shawn M. Hall, Merry B. McLaird, Takashi Yasukawa, Teijiro Aso, Jesper Q. Svejstrup, Joan W. Conaway, et al. Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage. JOURNAL OF BIOLOGICAL CHEMISTRY. 2017. 292. 16. 6431-6437
Harumasa Nakazawa, Kyungho Chang, Shohei Shinozaki, Takashi Yasukawa, Kazuhiro Ishimaru, Shingo Yasuhara, Yong-Ming Yu, J. A. Jeevendra Martyn, Ronald. G. Tompkins, Kentaro Shimokado, et al. iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-kappa B and p53. PLOS ONE. 2017. 12. 1. e0170391
Juston C. Weems, Brian D. Slaughter, Jay R. Unruh, Shawn M. Hall, Merry B. McLaird, Joshua M. Gilmore, Michael P. Washburn, Laurence Florens, Takashi Yasukawa, Teijiro Aso, et al. Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses. JOURNAL OF BIOLOGICAL CHEMISTRY. 2015. 290. 24. 15030-15041
Junya Kawauchi, Makoto Inoue, Mizue Fukuda, Yohei Uchida, Takashi Yasukawa, Ronald C. Conaway, Joan W. Conaway, Teijiro Aso, Shigetaka Kitajima. Transcriptional Properties of Mammalian Elongin A and Its Role in Stress Response. JOURNAL OF BIOLOGICAL CHEMISTRY. 2013. 288. 34. 24302-24315

ｍore...

MISC (6)：

Makoto Inoue, Junya Kawauchi, Mizue Fukuda, Yohei Uchida, Takashi Yasukawa, Ronald Conaway, Joan Conaway, Teijiro Aso, Shigetaka Kitajima. Transcriptional properties of mammalian Elongin A and its role in stress response. FASEB JOURNAL. 2014. 28. 1
Teijiro Aso, Takumi Kamura, Shigetaka Kitajima, Ronald C. Conaway, Joan W. Conaway, Takashi Yasukawa. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. FASEB JOURNAL. 2009. 23
T Yasukawa, M Kaneki, S Yasuhara, JAJ Martyn. Steroidal nondepolarizing muscle relaxants do not simulate the effects of glucocorticoids on glucocorticoid receptor-mediated transcription in cultured skeletal muscle cells. CRITICAL CARE MEDICINE. 2003. 31. 12. A38-A38
M Kaneki, E Tokunaga, H Sugita, T Yasukawa, J Martyn. S-nitrosylation-mediated inactivation ofAkt/PKB in cultured cells and diabetic (db/db) mice. DIABETES. 2003. 52. A289-A290
Y Hashimoto, T Niikura, H Tajima, T Yasukawa, H Sudo, Y Ito, Y Kita, M Kawasumi, K Kouyama, M Doyu, et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and A beta (vol 98, pg 6336, 2001). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001. 98. 22. 12854-12854

ｍore...

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page