Research theme for competitive and other funds (12)：
2024 - 2027 全身の代謝および老化からみたアルツハイマー病の解析
2022 - 2025 成熟前および成熟後Mafaノックアウトによる膵β細胞成熟機構の解明
2021 - 2024 Functional analysis of a novel membrane protein involved in the quality control of insulin in pancreatic beta cells
2021 - 2024 糖尿病や加齢が認知症の後天的危険因子である分子メカニズムの多角的解明
2019 - 2022 Molecular elucidation of two-step maturation process using immature pancreatic beta cell lines
2017 - 2020 Interactions between diabetes, aging and dementia
2016 - 2019 Analysis of the pancreatic beta cell maturation using Mafa-knockout MIN6 cells.
2014 - 2017 Functional analyses of Zac1: a candidate gene for chromosome 6q24-related transient neonatal diabetes mellitus
2014 - 2017 Analysis of the mechanism of homeostatic maintenance against Alzheimer's disease and its failure due to diabetes
2013 - 2015 Transdifferentiation of pancreatic exocrine cells to beta cells
2008 - 2009 Beta cell regeneration induced by the tetracycline-regulated expression of a pancreas-specific gene in mice.
2005 - 2006 転写因子遺伝子導入によるES細胞からのインスリン産生細胞の分化誘導の研究
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Papers (31)：
Satsuki Miyazaki, Hiroyuki Yamano, Daisuke Motooka, Fumi Tashiro, Takumi Matsuura, Tatsushi Miyazaki, Jun-Ichi Miyazaki. Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells. Communications biology. 2023. 6. 1. 771-771
Yasuki Nagai, Taka-Aki Matsuoka, Naoki Shimo, Takeshi Miyatsuka, Satsuki Miyazaki, Fumi Tashiro, Jun-Ichi Miyazaki, Naoto Katakami, Iichiro Shimomura. Glucotoxicity-induced suppression of Cox6a2 expression provokes β-cell dysfunction via augmented ROS production. Biochemical and biophysical research communications. 2021. 556. 134-141
Satsuki Miyazaki, Fumi Tashiro, Takashi Tsuchiya, Kazuki Sasaki, Jun-Ichi Miyazaki. Establishment of a long-term stable β-cell line and its application to analyze the effect of Gcg expression on insulin secretion. Scientific reports. 2021. 11. 1. 477-477
Kenta Niimi, Misaki Kohara, Eriko Sedoh, Moe Fukumoto, Satoshi Shibata, Toshinori Sawano, Fumi Tashiro, Satsuki Miyazaki, Yoshiaki Kubota, Jun-ichi Miyazaki, et al. FOXO1 regulates developmental lymphangiogenesis by upregulating CXCR4 in the mouse-tail dermis. Development. 2020. 147. 2. dev181545-dev181545
Moe Fukumoto, Kanako Kondo, Kazumasa Uni, Tomoko Ishiguro, Mikiko Hayashi, Shinnosuke Ueda, Itsuki Mori, Kenta Niimi, Fumi Tashiro, Satsuki Miyazaki, et al. Tip-cell behavior is regulated by transcription factor FoxO1 under hypoxic conditions in developing mouse retinas. Angiogenesis. 2018. 21. 2. 203-214
