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J-GLOBAL ID：201801012780020926   Update date: Mar. 16, 2025

Nabekura Tsukasa

ナベクラ ツカサ | Nabekura Tsukasa
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Affiliation and department：
Aichi Cancer Center, Research Institute Division of Immune Response

About Aichi Cancer Center, Research Institute Division of Immune Response


Job title： Chief
Other affiliations (1)：
Homepage URL  (2)： https://cancer-c.pref.aichi.jp/research-institute/immune-response/ ,  https://scholar.google.com/citations?hl=en&user=j0r_5S4AAAAJ&view_op=list_works&sortby=pubdate
Research field  (2)： Immunology ,  Tumor diagnostics and therapeutics
Research keywords  (14)： Natural killer cells ,  NK cells ,  Immunology ,  Tumor immunology ,  Immunological memory ,  NK receptors ,  Cell biology ,  Cancer immunotherapy ,  Innate lymphoid cells ,  Viral infection ,  Flow cytometry ,  primary cell culture ,  Hematology ,  Bone marrow transplantation
Research theme for competitive and other funds  (31)：
  • 2022 - 2029 記憶NK細胞の人為的分化誘導法の開発とその応用
  • 2025 - 2028 記憶細胞分化とがん免疫の抑制因子を標的にした次世代CARナチュラルキラー細胞の開発
  • 2025 - 2027 次世代キメラ抗原受容体ナチュラルキラー細胞がん免疫療法の開発
  • 2024 - 2027 転写機構改変による自己複製能を持つCAR-NK細胞の開発
  • 2025 - 2026 次世代ナチュラルキラー細胞療法の開発に向けた基盤技術の構築
Show all
Papers (45)：
  • Nabekura,Tsukasa, Matsuo,Soichi, Shibuya,Kazuko, Shibuya,Akira. CD96 enhances the anti-viral activity of natural killer cells by promoting Ly49H-mediated activation during mouse cytomegalovirus infection. MOLECULAR IMMUNOLOGY. 2025. 179. 65-70
  • Immunological memory in natural killer cells. INTERNATIONAL IMMUNOLOGY. 2025
  • Immunological memory of natural killer cells. 2024. 82. 5
  • Nabekura,Tsukasa, Matsuo,Soichi, Shibuya,Akira. Concanavalin A-induced acute liver injury in mice. CURRENT PROTOCOLS. 2024. 4. 8. e1117
  • Deborah, Elfira Amalia, Nabekura, Tsukasa, Shibuya, Kazuko, Shibuya, Akira. THEMIS2 Impairs Antitumor Activity of NK Cells by Suppressing Activating NK Receptor Signaling. JOURNAL OF IMMUNOLOGY. 2024. 212. 11. 1819-1828
ｍore...
MISC (1)：
  • Tsukasa Nabekura, Lewis Lanier. DNAM-1 is required for expansion of effector NK cells and generation of memory NK cells during mouse cytomegalovirus infection. JOURNAL OF IMMUNOLOGY. 2013. 190
Patents (7)：
  • ACTIVITY MODULATOR, MEDICINAL AGENT COMPRISING SAME, USE OF CD300A GENE-DEFICIENT MOUSE, AND ANTI-CD300A ANTIBODY
  • NKp46-CreERT2 transgenic mice
  • 活性調節剤、これを含有する医薬品、および抗CD300a抗体
  • ACTIVITY MODULATOR, MEDICINAL AGENT COMPRISING SAME, USE OF CD300A GENE-DEFICIENT MOUSE, AND ANTI-CD300A ANTIBODY
  • Use of Celiac disease-associated CD300a gene-deficient mouse, activity modulator for CD300a-expressing cells, and medical and pharmaceutical agent comprising activity modulators for CD300a-expressing cells
ｍore...
Books (1)：
  • An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2
    2008
Lectures and oral presentations  (47)：
  • Themis2 impairs anti-tumor activity of natural killer cells
    (Aichi Cancer Center 60th Anniversary Symposium jointly held with MD Anderson Cancer Center 2025)
  • Themis2 regulates natural killer cell memory function and formation
    (2024)
  • Themis2 impairs anti-tumor activity of NK cells by suppressing activating NK receptor signaling
    (第52回日本免疫学会学術集会 2024)
  • DNAM-1 immunoreceptor protects mice from concanavalin A-induced acute liver injury by reducing neutrophil infiltration
    (第52回日本免疫学会学術集会 2024)
  • DNAM-1 deficiency exacerbates Concanavalin A-induced acute liver injury through neutrophil infiltration
    (2024)
ｍore...
Education (1)：
  • 2005 - 2008 University of Tsukuba Graduate School of Comprehensive Human Sciences Doctoral Program in Advanced Biomedical Applications
Professional career (1)：
  • Ph.D. (University of Tsukuba)
Work history (7)：
  • 2024/11 - 現在 Nagoya University Graduate School of Medicine Division of Cellular Oncology, Department of Cancer Diagnostics and Therapeutics Professor
  • 2024/06 - 現在 Aichi Cancer Center, Research Institute Division of Immune Response Chief
  • 2018/04 - 2024/05 University of Tsukuba Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), Department of Immunology Assistant Professor
  • 2014/03 - 2018/03 University of Tsukuba Life Science Center of Tsukuba Advanced Research Alliance (TARA), Department of Immunology International Tenure-track Assistant Professor
  • 2014/11 - 2016/10 University of California, San Francisco Department of Microbiology and Immunology Assistant Specialist
Show all
Committee career (28)：
  • 2024/11 - 現在 愛知県がんセンター研究所 バイオバンク利活用推進審査委員会
  • 2024/11 - 現在 中部先端医療開発円環コンソーシアム 実務者 シーズ発掘・評価WG
  • 2024/11 - 現在 中部先端医療開発円環コンソーシアム 実務者 産学連携WG
  • 2024/11 - 現在 中部先端医療開発円環コンソーシアム 実務者 人材育成WG
  • 2024/10 - 現在 公私立大学実験動物施設協議会 代議員
Show all
Awards (15)：
  • 2018/11 - Young Investigator Award in University of Tsukuba
  • 2018/02 - University of Tsukuba BEST FACULTY MEMBER in University of Tsukuba
  • 2017/12 - The Japanese Society of Immunology Young Investigator Award
  • 2013/05 - American Association of Immunologists AAI Trainee Abstract Award of IMMUNOLOGY 2013 Annual Meeting, The American Association of Immunologists
  • 2012/11 - Japan Society for the Promotion of Science Postdoctoral Fellowship for Research Abroad of the Japan Society for the Promotion of Science (JSPS)
Show all
Association Membership(s) (6)：
Japanese Association of Cancer Immunology ,  Japanese Cancer Association ,  Japanese Society of Immunotherapy for Hematological Disorders ,  The American Association of Immunologists ,  JAPANESE SOCIETY FOR IMMUNOLOGY ,  THE JAPANESE SOCIETY OF HEMATOLOGY
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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