Nakada Shinichiro

Affiliation and department：
Job title：教授
Other affiliations (2)：

Homepage URL (1)： http://www.bcr.med.osaka-u.ac.jp

Research field (1)： Molecular biology

Research keywords (4)：ゲノム恒常性 , DNA修復 , ゲノム編集 , DNA損傷応答

Research theme for competitive and other funds (15)：

2022 - 2026 Muliple nicks-induced interhomolog recombination
2021 - 2025 DNA1本鎖損傷により誘導される染色体構造異常発生機構の解明
2019 - 2022 DNA2本鎖切断修復制御の中核となるユビキチン依存的DNA損傷応答の解明
2019 - 2022 Elucidation of the mechanism underlying DNA replication stress response regulating genomic instability
2018 - 2022 New development of genome editing technologies and disease models

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Papers (36)：

Akiko Tomita, Hiroyuki Sasanuma, Tomoo Owa, Yuka Nakazawa, Mayuko Shimada, Takahiro Fukuoka, Tomoo Ogi, Shinichiro Nakada. Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells. Nature communications. 2023. 14. 1. 5607-5607
Yoko Katsuki, Masako Abe, Seon Young Park, Wenwen Wu, Hiromasa Yabe, Miharu Yabe, Haico van Attikum, Shinichiro Nakada, Tomohiko Ohta, Michael M. Seidman, et al. RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair. Cell Reports. 2021. 37. 4. 109879-109879
Yasuyoshi Oka, Motoharu Hamada, Yuka Nakazawa, Hideki Muramatsu, Yusuke Okuno, Koichiro Higasa, Mayuko Shimada, Honoka Takeshima, Katsuhiro Hanada, Taichi Hirano, et al. Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome. SCIENCE ADVANCES. 2020. 6. 51
Remi Akagawa, Hai Thanh Trinh, Liton Kumar Saha, Masataka Tsuda, Kouji Hirota, Shintaro Yamada, Atsushi Shibata, Masato T Kanemaki, Shinichiro Nakada, Shunichi Takeda, et al. UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks. iScience. 2020. 23. 4. 101027-101027
Yuka Nakazawa, Yuichiro Hara, Yasuyoshi Oka, Okiru Komine, Diana van den Heuvel, Chaowan Guo, Yasukazu Daigaku, Mayu Isono, Yuxi He, Mayuko Shimada, et al. Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair. Cell. 2020. 180. 6. 1228-1244

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MISC (21)：

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Patents (3)：

Education (2)：

2001 - 2005 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
1992 - 1998 Tokyo Medical and Dental University Faculty of Medicine School of Medicine

Awards (6)：

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