Rchr
J-GLOBAL ID：201801016926108419
Update date: Jan. 17, 2024
Han Song-iee
Han Song-iee
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Affiliation and department：
University of Tsukuba
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Research field (2)：
Metabolism and endocrinology
, Molecular biology
Research keywords (4)：
転写
, lipid metabolism
, protease
, SREBP
Research theme for competitive and other funds (3)：
2019 - 2022 新規SREBP-1プロテアーゼR4によるlipid-sensing分子機構の解明
2016 - 2019 SREBP-1活性化を制御する新奇プロテアーゼによる新たな脂質代謝制御機構の解明
2014 - 2016 エネルギー代謝における転写因子複合体形成と遺伝子発現制御
Papers (25)：
Masaya Araki, Yoshimi Nakagawa, Asayo Oishi, Song-iee Han, Yunong Wang, Kae Kumagai, Hiroshi Ohno, Yuhei Mizunoe, Hitoshi Iwasaki, Motohiro Sekiya, et al. The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. International Journal of Molecular Sciences. 2018. 19. 7. E2148
Hiroshi Ohno, Takashi Matsuzaka, Nie Tang, Rahul Sharma, Kaori Motomura, Takuya Shimura, Aoi Satoh, Song-Iee Han, Yoshinori Takeuchi, Yuichi Aita, et al. Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance. Endocrinology. 2018. 159. 6. 2308-2323
Yuta Yamamoto, Kenta Takei, Sundaram Arulmozhiraja, Vladimir Sladek, Naoya Matsuo, Song-iee Han, Takashi Matsuzaka, Motohiro Sekiya, Takaki Tokiwa, Mitsuo Shoji, et al. Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα. Biochemical and Biophysical Research Communications. 2018. 499. 2. 239-245
Hui Zhao, Takashi Matsuzaka, Yuta Nakano, Kaori Motomura, Nie Tang, Tomotaka Yokoo, Yuka Okajima, Song-iee Han, Yoshinori Takeuchi, Yuichi Aita, et al. Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding beta-Cell Mass and Increasing Insulin Secretory Capacity. DIABETES. 2017. 66. 7. 1833-1846
Kenta Takei, Song-iee Han, Yuki Murayama, Aoi Satoh, Fusaka Oikawa, Hiroshi Ohno, Yoshinori Osaki, Takashi Matsuzaka, Motohiro Sekiya, Hitoshi Iwasaki, et al. Selective peroxisome proliferator-activated receptor-alpha modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-alpha pathway and improves lipid metabolism in mice. JOURNAL OF DIABETES INVESTIGATION. 2017. 8. 4. 446-452
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Lectures and oral presentations (13)：
MafAはリン酸によりBeta2/NeuroD1との相互作用が亢進する
(第39回日本分子生物学会 2016)
Gata3はSP1との相互作用を介してMafB及びGcm2と協調的に副甲状腺ホルモン遺伝子の発現を活性化する
(第38回日本分子生物学会・第88回日本生化学大会 合同大会 2015)
MafAのリン酸化によるインスリン遺伝子転写制御と膵臓β細胞疲弊
(転写サイクル・転写代謝システム・転写研究会共催「若手ワークショップ2014」 2014)
核内受容体ER/LXRクロストークによる脂質代謝制御機構の解明
(転写研究会・転写サイクル・転写代謝システム共催「若手ワークショップ@鬼怒川」 2013)
Non-classical ER/LXR pathway in lipid metabolism
(2012)
ｍore...
Education (2)：
1998 - 2004 Tokyo Institute of Technology
1994 - 1998 梨花女子大学 自然科学科
Work history (5)：
2019/02 - 現在 University of Tsukuba International Institute for Integrative Sleep Medicine
2014/04 - 2019/01 University of Tsukuba Faculty of Medicine
2011/04 - 2014/03 横浜市立大学 / 筑波大学 生命医科学研究科 / 生命環境系 日本学術振興会 特別研究員RPD
2006/04 - 2011/03 University of Tsukuba Faculty of Life and Environmental Sciences
2004/04 - 2006/03 Nara Institute of Science and Technology Graduate School of Biological Sciences
Association Membership(s) (1)：
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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