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J-GLOBAL ID：201801017596153028 Update date: Apr. 02, 2025

Nagayasu Takeshi

ナガヤスタケシ | Nagayasu Takeshi

Affiliation and department：
Job title： Professor & Chairman
Other affiliations (1)：

長崎大学病院腫瘍外科診療科長

Homepage URL (1)： http://www.med.nagasaki-u.ac.jp/surgery1/

Research field (4)： General surgery, pediatric surgery , Respiratory surgery , Respiratory surgery , Respiratory surgery

Research keywords (5)： medical engineering , tracheal regeneration , lung regeneration , lung transplantation , lung cancer

Research theme for competitive and other funds (58)：

2023 - 2026 脂肪幹細胞での肛門機能低下の新規予防法開発と人工肛門括約筋による肛門機能再生研究
2023 - 2026 バイオ3Dプリンティング技術を応用した、人工子宮構造体によるラット子宮の部分再生
2023 - 2026 Establishment of an in vitro human pulmonary fibrosis model using a novel culture system of alveolar organoids
2022 - 2026 Research on the effects of microplastics accumulated in airway and lung specimens on respiratory diseases
2022 - 2025 Basic research on the production of basic artificial organ skeletons and on the mass production and quality improvement

2022 - 2025 Ex vivo再生肺による肺線維症モデルとマクロファージの役割の解明

2022 - 2025 Development of rectal anastomosis device using tissue fusion technology and establishment of management for prevention of anastomotic leakage

2022 - 2025 Expanding of indication about the new diagnostic kit to detect lymph node metastases for breast cancer patients with preoperative systemic therapy

2022 - 2025 肺オルガノイド細胞療法による肺再生の基盤技術の開発

2021 - 2024 ウルトラファインバブル(ナノバブル)水を使用した創傷治癒促進戦略

2021 - 2024 ゼラチンマイクロスフェアを用いた増殖因子投与による人工管腔臓器作製法の開発

2021 - 2024 臍帯組織、臍帯血より抽出した細胞による人工気管作製による気道再生法の確立

2021 - 2024 カーボンナノチューブを用いた自己細胞からなる人工管腔臓器の新たな作製技術の確立

2021 - 2024 脂肪幹細胞による肺胞バリア機能強化とALI/ARDSへの新たな細胞治療の基礎研究

2020 - 2023 短腸症候群に対する自己細胞のみからなる人工小腸による再生医療

2020 - 2023 バイオ3Dプリンターを用いた人工臓器作成におけるiPS細胞応用に関する基礎研究

2020 - 2023 脱細胞・再細胞による再生医療と異種移植によるハイブリッド気道移植モデルの開発

2020 - 2023 ナノバブルを用いた新たな臓器保存液の臨床応用に向けた有効性の確立とシステム開発

2020 - 2023 スキャフォールドフリーの3次元構造体による機能を有する人工尿管の作成

2019 - 2023 組織骨格を利用した再生臓器におけるハイブリッド型血管ニッチの確立と移植研究

2019 - 2023 革新的な新規リキッドバイオプシー法を用いた新しい乳癌の診断・治療法の探索

2018 - 2023 Scaffold-free artificial trachea for tracheal deiseases

2019 - 2022 Development of rejection control method by mesenchymal stem cells using original rat lung transplantation model

2019 - 2022 Development of a Novel Respiratory Surgical Coating Material Using Freeze- and Vaccum-Dried Human Amniotic Membranes

2018 - 2021 Study on molecular cytological analysis of the pathogenic mechanism of familial lung adenocarcinoma

2017 - 2020 Generation of the small human lungs as the novel ex vivo lung cancer study models

2017 - 2020 Regenerative medicine for esophagus using a scaffold-free structure created with bio-three-dimensional printing technology

2017 - 2020 Development of a new oragan preservation solution for lung transplantation using nanobublized solution contained nitrogen

2017 - 2020 Treatment of lymphedema with super microsurgery and bio-3D printing technique

2016 - 2019 Development of a novel diagnostic kit to detect lymph nodes in thyroid papillary carcinoma

2016 - 2019 Reducing ischemic lung perfusion injury by artificial hemoglobin

2016 - 2019 Development of a new culture method for cell culture and three-dimensional structure using oxygen nanobubbles

2015 - 2019 Transplantation studies of tissue engineered tracha and lung regenerated from recellularized xenogeneic-decellularized scaffold

2015 - 2018 Search of the responsible gene mutations associated with familial hereditary lung cancer

2015 - 2018 The new methods of treatment for the anastomotic leakage of the trachea with regenetrative medicial application

2015 - 2018 Development of an antenna system for radio wave type laparoscope

2014 - 2018 Functional analysis of new biomarkers (Runx3, EZH2) in Gastroesophageal junction cancer

2014 - 2018 Establishment of the new surgical education using VR System and the 3D-Printing technology

2013 - 2017 Medical-Engineering Hybrid Professional Development Program

2014 - 2017 Immunofluorescence analysis of P53-binding protein 1 in thyroid follicular tumours

2014 - 2017 Scaffold-free trachea and lung tissue engineering using bio-3D printing system

2014 - 2017 Basic researches for the improvement of the fragility and the organ portection about de-and re-cellularization based regenerated lung

2014 - 2017 Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer

2013 - 2016 Novel method for tracheal diseases and pulmonary diseases

2013 - 2016 Germline mutations causing familial lung cancer

2013 - 2016 Development of Local Treatment for Bile Duct Carcinoma by PDT Applying the New Glucose-Conjugated Chlorin

2014 - 2016 Development of Telemedicine System for Home Health Care

2011 - 2014 Establishment of therapeutic strategy for synchronous double lung cancers based on molecular analysis

2011 - 2013 New role of stem cells in the GFP-rat lung transplantation model

2011 - 2013 The study of tissue protection and cell implantation effects by adipose tissue derived stromal cells for future usage in damaged or transplanted lung

2009 - 2011 Development of new treatment applying photodynamic therapy in bile duct carcinoma

2008 - 2010 The effects of adiponectin on lung cancer and lung disease

2008 - 2010 A examination of KGF seat to prevent bronchpleural fistula.

2007 - 2009 Prospective non-randomized trial comparing esophagectomy versus definitive chemoradiation for potentially-resectable esophageal cancer : multi-institutional study

2006 - 2007 Gene therapy for lung emphysema

2005 - 2006 Anthropological prospect of earwax determining gene and association between earwax and breast cancer

2004 - 2005 Keratinocyte growth factor is a potent modulator of lung compensatory regeneration after lobectomy

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Papers (1,437)：

Ethan N. Okoshi, Shiro Fujita, Kris Lami, Yuka Kitamura, Ryuta Matsuda, Andrey Bychkov, Takuro Miyazaki, Keitaro Matsumoto, Takeshi Nagayasu, Junya Fukuoka. Progression to invasive carcinoma: cellular activities and immune-related pathways define the lepidic and acinar subtypes of lung adenocarcinoma. Pathology. 2025
Kaido Oishi, Keitaro Matsumoto, Shintaro Hashimoto, Fumitake Uchida, Ryosuke Hara, Masato Nishimuta, Takamune Matsumoto, Mayumi Iwatake, Koichi Tomoshige, Ryoichiro Doi, et al. Spheroid Morphology of Lung Cancer Cell Lines Correlates with Oncological Profiles. 2024
Fumitake Uchida, Keitaro Matsumoto, Masato Nishimuta, Takamune Matsumoto, Kaido Oishi, Ryosuke Hara, Ryusuke Machino, Daisuke Taniguchi, Shosaburo Oyama, Masaaki Moriyama, et al. Fabrication of a three-dimensional scaffold-free trachea with horseshoe-shaped hyaline cartilage. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2024. 66. 4
Mayumi Iwatake, Tokiko Nagamura-Inoue, Ryoichiro Doi, Yukinori Tanoue, Mitsutoshi Ishii, Hiroshi Yukawa, Keitaro Matsumoto, Koichi Tomoshige, Takeshi Nagayasu, Tomoshi Tsuchiya. Designer umbilical cord-stem cells induce alveolar wall regeneration in pulmonary disease models. Frontiers in Immunology. 2024. 15
Yoshito Imamura, Daisuke Nakajima, Takashi Kanou, Yasushi Shintani, Seiichiro Sugimoto, Shinichi Toyooka, Yasushi Hoshikawa, Keitaro Matsumoto, Takeshi Nagayasu, Hidemi Suzuki, et al. Effect of revised organ transplant law in Japan on lung transplantation. Surgery today. 2024

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MISC (589)：

時任高諄, 城戸貴志, 永淵修, 朝重耕一, 松本理宗, 溝口聡, 由良博一, 石本裕士, 篠塚賢一, 中澤暦, et al. Detection of microplastics using respiratory specimens. 日本呼吸器学会誌(Web). 2024. 13
小坂太一郎, 藤田拓郎, 宮本大輔, 篠原彰太, 山根裕介, 日高匡章, 永安武, 江口晋. 当科における胆道閉鎖症の治療戦略-葛西手術における肝門部索状物切離時のICG蛍光造影法の有用性の検討と再生医療を用いた治療戦略-. 日本外科学会定期学術集会(Web). 2023. 123rd
岩竹真弓, 土谷智史, 土谷智史, 長村登紀子, 住田吉慶, 松本桂太郎, 永安武. デザイナー臍帯由来間葉系幹細胞による新規肺疾患治療法の開発. 日本再生医療学会総会(Web). 2023. 22nd
篠原彰太, 山根裕介, 高瀬雄介, 谷岡真司, 舩越康智, 永安武. 腹腔鏡併用により経腹経仙骨的切除を安全に施行しえた仙骨Ewing肉腫の1例. 日本小児血液・がん学会雑誌. 2022. 59. 4. 319-319
望月保志, 松田剛, 迎祐太, 中西裕美, 曽山明彦, 宮崎拓郎, 平尾朋仁, 日宇健, 関野元裕, 竹田昭子, et al. 脳死下臓器提供数増加を目指した院内連携システムの構築と活動. 日本臨床腎移植学会プログラム・抄録集. 2022. 55th

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Patents (11)：

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Lectures and oral presentations (20)：

内頸静脈端側吻合に対するSatinsky型サメ肌血管鉗子の開発
(日本マイクロサージャリー学会学術集会プログラム・抄録集 2019)
エリブリンの有効性および安全性の後方視的検討
(日本乳癌学会総会プログラム抄録集 2019)
コンパニオン診断と遺伝学的検査としてのBRCA遺伝子に関する包括的マネージメントと地域連携について
(日本乳癌学会総会プログラム抄録集 2019)
乳癌の針生検と手術材料によるHER2評価の比較
(日本乳癌学会総会プログラム抄録集 2019)
当院におけるティッシュエキスパンダーによる一次二期乳房再建術についての検討
(日本乳癌学会総会プログラム抄録集 2019)

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Education (2)：

1992 - 1996 Nagasaki University Graduate School
1982 - 1987 Nagasaki University School of Medicine

Professional career (1)：

M.D.,Ph.D.

Work history (15)：

2023/10 - 現在 Nagasaki University President
2021/09 - 現在 Nagasaki University Trustee (Strategic Development and Research)
2019/10 - 現在 Nagasaki University Trustee and Vice President (Research and International Affairs)
2017/04 - 現在 Nagasaki University School of Medicine Dean
2013/10 - 現在 Nagasaki University Graduate School of Biomedical Sciences Medical-Engineering Hybrid Professional Training Center Director

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Committee career (7)：

2023/05 - 現在日本呼吸器内視鏡学会理事
2019/05 - 現在日本呼吸器外科学会監事
2018/12 - 現在日本内視鏡外科学会理事
2018/05 - 2019/05 日本呼吸器内視鏡学会副理事長
2017/05 - 2019/05 日本呼吸器外科学会副理事長

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Awards (2)：

2006/10 - The Japanese Association for Thoracic Surgery 2006 Best paper awards Beneficial Effects of Plasmapheresis before Thymectomy on the Outcome in Myasthenia Gravi
2002/09 - 19th International Congress of The Transplantation Society Travel Grant Awards

Association Membership(s) (8)：

THE JAPAN LUNG CANCER SOCIETY , THE JAPAN SOCIETY FOR TRANSPLANTATION , JAPAN SOCIETY FOR ENDOSCOPIC SURGERY , THE JAPAN BRONCHO-ESOPHAGOLOGICAL SOCIETY , THE JAPAN SOCIETY FOR RESPIRATORY ENDOSCOPY , The Japanese Association for Chest Surgery , THE JAPANESE ASSOCIATION FOR THORACIC SURGERY , JAPAN SURGICAL SOCIETY

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