Yasuda Kaori

ヤスダカオリ | Yasuda Kaori

Affiliation and department：

Research field (2)： Nutrition and health science , Pharmaceuticals - health and biochemistry

Research keywords (3)：ビタミンD , Biochemistry , Drug metabolism

Research theme for competitive and other funds (14)：

2023 - 2026 Synthesis of half-life prolonging vitamin D derivatives and analysis of enhancement of hormone-effects on disease animal models
2022 - 2025 遺伝子疾患動物評価系を用いたビタミンD誘導体の開発および遺伝子治療法の確立
2020 - 2023 循環腫瘍細胞・セルクラスター・セルフリー核酸を調べつくすためのシンプルな分離法
2019 - 2022 Elucidation of vitamin D actions using genetically modified rats and application of vitamin D analogs to medical drugs
2019 - 2022 Development of diagnostic and preventive methods for diseases involving vitamin D metabolism

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Papers (83)：

Yuichiro Iwai, Ayano Iijima, Satoko Kise, Chika Nagao, Yuto Senda, Kana Yabu, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, et al. Characterization of Rickets Type II Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor. Biomolecules. 2023. 13. 11
Satoko Kise, Ayano Iijima, Chika Nagao, Tadashi Okada, Miyu Nishikawa, Shinichi Ikushiro, Tomoko Nakanishi, Shigeto Sato, Kaori Yasuda, Toshiyuki Sakaki. Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector. Scientific reports. 2023. 13. 1. 18528-18528
Takuya Kushioka, Hiroki Mano, Sayuri Matsuoka, Miyu Nishikawa, Kaori Yasuda, Shinichi Ikushiro, Toshiyuki Sakaki. Analysis of vitamin D metabolites in biological samples using a nanoluc-based vitamin D receptor ligand sensing system: NLucVDR. The Journal of steroid biochemistry and molecular biology. 2023. 233. 106367-106367
Fumihiro Kawagoe, Sayuri Mototani, Kaori Yasuda, Akiko Takeuchi, Hiroki Mano, Shinji Kakuda, Hiroshi Saitoh, Toshiyuki Sakaki, Atsushi Kittaka. Synthesis of (22R)-, (22S)-22-Fluoro-, and 22,22-Difluoro-25-hydroxyvitamin D₃ and Effects of Side-Chain Fluorination on Biological Activity and CYP24A1-Dependent Metabolism. The Journal of Organic Chemistry. 2023
Yuka Mizumoto, Ryota Sakamoto, Kazuto Iijima, Naoto Nakaya, Minami Odagi, Masayuki Tera, Takatsugu Hirokawa, Toshiyuki Sakaki, Kaori Yasuda, Kazuo Nagasawa. Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D3 and Identification of Their Metabolites. Biomolecules. 2023. 13. 7. 1036-1036

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MISC (106)：

鎌田成栄, 和田萌加, 山形昌也, 水谷公彦, 三上文三, 三上文三, 大橋錬, 佐久間宙, 根本翔, NILOUYAL Somaye, et al. 放線菌由来P450(CYP105A1)の機能改変と医薬品代謝研究への応用:R84A変異体による非ステロイド性抗炎症薬(NSAIDs)の代謝. 生物高分子. 2023. 23. 2
木瀬智子, 安田佳織, 西川美宇, 榊利之. ビタミンD受容体遺伝子欠損によるII型くる病に対する遺伝子治療およびゲノム編集治療の可能性-Possibility of gene therapy and genome-editing therapy for type II rickets caused by vitamin D receptor deficiency. ビタミン = Vitamins. 2022. 96. 2. 41-45
岩井悠一郎, 大下遥己, 真野寛生, 川越文裕, 高野真史, 橘高敦史, 榊利之, 安田佳織. 側鎖にフッ素を有するビタミンD誘導体の代謝およびヒト乳がん細胞株に対する増殖抑制効果. ビタミン. 2022. 96. 4
長尾知佳, 安田佳織, 岡田只士, 岡田只士, 西川美宇, 生城真一, 中西友子, 斎藤泉, 榊利之. ビタミンD1α位水酸化酵素発現アデノウイルスベクターを用いたI型くる病モデルラットの治療. ビタミン. 2022. 96. 4
水本結花, 永田亜希子, 坂本良太, 岩城海帆, 飯島一翔, 安田佳織, 榊利之, 高橋康司, 福沢世傑, 小田木陽, et al. Synthesis of 4, 25-dihydroxyvitamin D₃ and evaluation its biological activities. 日本化学会春季年会講演予稿集(Web). 2022. 102nd

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Patents (12)：

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Education (3)：

2013 - 2013 Toyama Prefectural University Faculty of Engineering
2002 - 2004 Kyoto University
1998 - 2002 Kyoto University Faculty of Engineering School of Industrial Chemistry

Professional career (1)：

博士(工学) (富山県立大学)

Work history (6)：

2023/04 - 現在 Toyama Prefectural University
2019/04 - 2023/03 Toyama Prefectural University
2017/04 - 2019/03 Toyama Prefectural University Faculty of Engineering
2016/04 - 2017/03 Toyama Prefectural University Faculty of Engineering, Department of Biotechnology
2008/10 - 2016/03 Toyama Prefectural University Faculty of Engineering, Department of Biotechnology

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Awards (5)：

2021/06 - 日本ビタミン学会 2021年度日本ビタミン学会奨励賞天然型ビタミンDおよびビタミンD誘導体の代謝と生理作用に関する研究
2019/05 - 22nd Workshop on Vitamin D Elsevier Poster Award Elucidation of 25-hydroxyvitamin D3 metabolism using Cyp24a1-knockout Rats generated by CRISPR/Cas9 System.
2017/11 - 日本薬物動態学会第32回年会ベストポスター賞 Comparative analysis of 25-hydroxyvitamin D3 metabolism between wild-type and CYP24A1-knockout rats.
2017/09 - Innovation Forums Basel Life 2017 1st prize of the Poster Award 2017 Application of actinomycetes CYP105A1 to the production of active forms of vitamin D or drug metabolites
2015/11 - The 6th International Conference on Food Factors (IcoFF 2015) Young Investigator Award Sesamin metabolism by drug-metabolizing enzymes and drug-sesamin interaction

Association Membership(s) (5)：

THE JAPANESE SOCIETY FOR BIOMATERIALS , THE VITAMIN SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS , THE PHARMACEUTICAL SOCIETY OF JAPAN

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