Takahashi Atsushi

Affiliation and department：
Job title： Director
Other affiliations (2)：

国立研究開発法人国立循環器病研究センター創薬オミックス解析センター副センター長
特定国立研究開発法人理化学研究所横浜研究所客員主幹研究員

Research field (2)： Systems genomics , Genomics

Research keywords (3)： Bioinformatics , Statistics , Statistical Genetics

Research theme for competitive and other funds (4)：

2023 - 2026 心臓発生期のゲノム網羅的エンハンサーアトラスと心臓内領域特異的遺伝子発現制御機構
2022 - 2025 Research for Risk Stratification of cerebral hemorrhage
2021 - 2024 周産期心筋症の病態-遺伝要因・心筋炎症・血管障害-解明研究
2019 - 2023 心臓突然死に関連する遺伝子異常・多型の解明と人工知能(AI)の応用

Papers (290)：

Keiko Yamazaki, Chikashi Terao, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Satoshi Asai, Yasuo Takahashi. Genome-wide Association Studies Categorized by Class of Antihypertensive Drugs Reveal Complex Pathogenesis of Hypertension with Drug Resistance. Clinical Pharmacology & Therapeutics. 2023. 114. 2. 393-403
Nilufer Rahmioglu, Sally Mortlock, Marzieh Ghiasi, Peter L Møller, Lilja Stefansdottir, Geneviève Galarneau, Constance Turman, Rebecca Danning, Matthew H Law, Yadav Sapkota, et al. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nature genetics. 2023. 55. 3. 423-436
Masato Akiyama, Saori Sakaue, Atsushi Takahashi, Kazuyoshi Ishigaki, Makoto Hirata, Koichi Matsuda, Yukihide Momozawa, Yukinori Okada, Toshiharu Ninomiya, Masaru Koido, et al. Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals. Communications Biology. 2023. 6. 1
Kazuo Miyazawa, Kaoru Ito, Masamichi Ito, Zhaonan Zou, Masayuki Kubota, Seitaro Nomura, Hiroshi Matsunaga, Satoshi Koyama, Hirotaka Ieki, Masato Akiyama, et al. Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction. Nature genetics. 2023. 55. 2. 187-197
Mika Hori, Atsushi Takahashi, Kiminori Hosoda, Masatsune Ogura, Mariko Harada-Shiba. A Low-Frequency APOB p.(Pro955Ser) Variant Contributes to the Severity of/Variability in Familial Hypercholesterolemia. The Journal of clinical endocrinology and metabolism. 2023. 108. 2. 422-432

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MISC (42)：

Saori Sakaue, Masahiro Kanai, Juha Karjalainen, Masato Akiyama, Mitja Kurki, Nana Matoba, Atsushi Takahashi, Makoto Hirata, Michiaki Kubo, Koichi Matsuda, et al. Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan. Nature medicine. 2020. 26. 4. 542-548
池田匡志, 高橋篤, 鎌谷洋一郎, 桃沢幸秀, 齋藤竹生, 近藤健治, 島崎愛夕, 川瀬康平, 作佐部太也, 岩山佳美, et al. Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect(和訳中). 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集. 2019. 29回・49回. 124-124
Chisato Shimizu, Jihoon Kim, Hariklia Eleftherohorinou, Victoria Wright, Long Hoang, Adriana Tremoulet, Alessandra Franco, Martin Hibberd, Atsushi Takahashi, Michiaki Kubo, et al. Genetic Variants in HLA-C and Class I Pathway Genes Influence Susceptibility to Kawasaki Disease. ARTHRITIS & RHEUMATOLOGY. 2017. 69
Makiko Taira, Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani, Michiaki Kubo, Momoko Horikoshi, Shiro Maeda. A Meta-analysis of Genome-Wide Association Studies for Susceptibility Loci to Diabetic Nephropathy in Japanese Patients with Type 2 Diabetes. DIABETES. 2017. 66. A473-A473
Low S-K, Takahashi A, Ebana Y, Ozaki K, Christophersen I E, Ellinor P T, Consortium A F, Ogishima S, Yamamoto M, Satoh M, et al. Identification of six new genetic loci associated with atrial fibrillation in the Japanese population. Nat Genet. 2017. 49. 6. 953-958

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Work history (11)：

2017/08 - 現在 RIKEN Laboratory for Statistical Analysis, Center for Integrative Medical Sciences
2016/11 - 現在 National Cerebral and Cardiovascular Center Omics Research Center Deputy Director
2016/11 - 現在 National Cerebral and Cardiovascular Center Department of Genomic Medicine Director
2015/04 - 2017/07 RIKEN Laboratory for Statistical Analysis, Center for Genomic Medicine Visiting Researcher
2015/04 - 2016/10 National Cerebral and Cardiovascular Center Laboratory for Omics Informatics, Omics Research Center Laboratory Chief

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Committee career (2)：

2017/08 - 現在 Journal of Human Genetics Editorial Board
2020/11 - 2023/11 The Japan Society of Human Genetics Councilor

Awards (1)：

2013/10 - The Japan Society of Human Genetics The Award for Young Investigator

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