Rchr
J-GLOBAL ID：201901003590085345   Update date: Apr. 17, 2024

Takashi Misawa

ミサワ タカシ | Takashi Misawa
Affiliation and department：
National Institute of Health Sciences

About National Institute of Health Sciences


Research field  (1)： Pharmaceuticals - chemistry and drug development
Research keywords  (2)： 創薬化学 ,  ペプチド化学
Research theme for competitive and other funds  (6)：
  • 2020 - 2023 Development of helical promoter sequence and its application for bioactive peptides.
  • 2018 - 2021 Development of cell penetrating peptides based on helical promoter for biomedical application
  • 2015 - 2019 Development of helical template peptides for post-functionalization
  • 2013 - 2015 Development of novel small molecules which rescue the trafficking of mutated ABCD1 responsible for adrenoleukodystrophy
  • 2010 - 2014 Chemical control of protein dramatype
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Papers (97)：
  • Motoharu Hirano, Hidetomo Yokoo, Nobumichi Ohoka, Takahito Ito, Takashi Misawa, Makoto Oba, Takao Inoue, Yosuke Demizu. Rational Design of Amphipathic Antimicrobial Peptides with Alternating L-/D-Amino Acids That Form Helical Structures. Chemical & pharmaceutical bulletin. 2024. 72. 2. 149-154
  • Takuji Shoda, Genichiro Tsuji, Maiko Kawamura, Takashi Kurohara, Takashi Misawa, Ruri Kikura-Hanajiri, Yosuke Demizu. Structural analysis of an lysergic acid diethylamide (LSD) analogue N-methyl-N-isopropyllysergamide (MiPLA): Insights from Rotamers in NMR spectra. Drug Testing and Analysis. 2023
  • Takahito Ito, Natsumi Matsunaga, Megumi Kurashima, Yosuke Demizu, Takashi Misawa. Enhancing Chemical Stability through Structural Modification of Antimicrobial Peptides with Non-Proteinogenic Amino Acids. Antibiotics. 2023. 12. 8
  • Takahito Ito, Wakana Hashimoto, Nobumichi Ohoka, Takashi Misawa, Takao Inoue, Ryuji Kawano, Yosuke Demizu. Structure-Activity Relationship Study of Helix-Stabilized Antimicrobial Peptides Containing Nonproteinogenic Amino Acids. ACS biomaterials science & engineering. 2023. 9. 8. 4654-4661
  • Rika Ishikawa, Kosuke Saito, Takashi Misawa, Yosuke Demizu, Yoshiro Saito. Identification of the Stapled α-Helical Peptide ATSP-7041 as a Substrate and Strong Inhibitor of OATP1B1 In Vitro. Biomolecules. 2023. 13. 6
ｍore...
MISC (98)：
  • Takashi Misawa, Yosuke Demizu. Developmental Trends of Peptide Drugs and Their Quality Assessment using Secondary Structure Analysis. ChemistrySelect. 2023. 8. 11
  • 水谷佐久美, 河村麻衣子, 田中理恵, 三澤隆史, 辻厳一郎, 黒原崇, 伊藤美千穂, 出水庸介, 花尻(木倉)瑠理. Simultaneous analysis of 23 compounds derived from constituents of cannabis. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 藤田陽, 藤田陽, 土屋圭輔, 土屋圭輔, 木吉真人, 石井明子, 三澤隆史, 出水庸介, 出水庸介. In silico design of peptides inhibiting Wnt/β-catenin pathway. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 河村麻衣子, 三澤隆史, 辻厳一郎, 黒原崇, 伊藤美千穂, 出水庸介, 花尻(木倉)瑠理. Study on analytical methods for derivatives of cannabis constituents. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 平野元春, 平野元春, 横尾英知, 大庭誠, 三澤隆史, 出水庸介, 出水庸介. Intracellular delivery of oligonucleotides using amphipathic stapled peptides. 日本薬学会年会要旨集(Web). 2023. 143rd
ｍore...
Work history (2)：
  • 2019/10 - 現在 National Institute of Health Sciences Division of Organic Chemistry
  • 2017/07 - 現在 国立医薬品食品衛生研究所 有機化学 主任研究官
Committee career (1)：
  • 2018/04 - 現在 独立行政法人医薬品医療機器総合機構 日本薬局方原案審議委員会化学薬品委員会委員
Awards (2)：
  • 2021/10 - 日本ペプチド学会 2021年度日本ペプチド学会 奨励賞
  • 2021/09 - 日本薬学会関東支部 2021年度日本薬学会関東支部 奨励賞
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