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J-GLOBAL ID：201901003590085345 Update date: Apr. 05, 2025

Takashi Misawa

ミサワタカシ | Takashi Misawa

Affiliation and department：

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (2)：創薬化学 , ペプチド化学

Research theme for competitive and other funds (6)：

2020 - 2023 Development of helical promoter sequence and its application for bioactive peptides.
2018 - 2021 Development of cell penetrating peptides based on helical promoter for biomedical application
2015 - 2019 Development of helical template peptides for post-functionalization
2013 - 2015 Development of novel small molecules which rescue the trafficking of mutated ABCD1 responsible for adrenoleukodystrophy
2010 - 2014 Chemical control of protein dramatype

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Papers (105)：

Rika Ishikawa, Takashi Misawa, Yosuke Demizu, Yoshiro Saito, Ruri Kikura-Hanajiri, Kosuke Saito. Comprehensive in vitro evaluation of the inhibitory effects of relatively high molecular weight peptides on drug-drug interaction-associated four liver transporters and its association with physicochemical properties. Drug Metabolism and Pharmacokinetics. 2025
Motoharu Hirano, Yuki Takechi-Haraya, Yasuhiro Abe, Takashi Misawa, Norihito Shibata, Yoji Sato, Yosuke Demizu. Mechanistic study of plasmid DNA delivery by Magainin 2-derived stapled peptides. Bioorganic & medicinal chemistry. 2025. 123. 118176-118176
Takahito Ito, Nobumichi Ohoka, Michihiko Aoyama, Takashi Nishikaze, Takashi Misawa, Takao Inoue, Akiko Ishii-Watabe, Yosuke Demizu. Correction: Strategic design of GalNAc-helical peptide ligands for efficient liver targeting. Chemical science. 2025. 16. 6. 2931-2933
Takahito Ito, Nobumichi Ohoka, Michihiko Aoyama, Takashi Nishikaze, Takashi Misawa, Takao Inoue, Akiko Ishii-Watabe, Yosuke Demizu. Strategic design of GalNAc-helical peptide ligands for efficient liver targeting. Chemical science. 2024
Michihiko Aoyama, Minoru Tada, Hidetomo Yokoo, Takahito Ito, Takashi Misawa, Yosuke Demizu, Akiko Ishii-Watabe. Linker and Conjugation Site Synergy in Antibody-Drug Conjugates: Impacts on Biological Activity. Bioconjugate chemistry. 2024

MISC (111)：

平野元春, 平野元春, 原矢佑樹, 阿部康弘, 三澤隆史, 柴田識人, 佐藤陽治, 出水庸介, 出水庸介. Intracellular transport of nucleic acids using amphiphilic stapled peptides and mechanism elucidation. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2024. 9th
三澤隆史, 伊藤貴仁, 伊藤貴仁, 倉島恵愛, 出水庸介, 出水庸介. Development of antimicrobial peptide foldamers containing cationic disubstituted amino acids. 日本薬学会年会要旨集(Web). 2024. 144th
藤田陽, 藤田陽, 菊地杏美香, 有田恭平, 三澤隆史, 出水庸介, 出水庸介. Development of peptides that inhibit the Wnt/β-catenin signaling pathwayusing in silico approach. 日本薬学会年会要旨集(Web). 2024. 144th
三澤隆史, 伊藤貴仁, 伊藤貴仁, 倉島恵愛, 山崎聖司, 西野邦彦, 出水庸介, 出水庸介. Development of antimicrobial peptide foldamers as therapeutics for multi-drug resistant bacteria. 日本細菌学雑誌(Web). 2024. 79. 2
橋井則貴, 蛭田葉子, 三澤隆史, 大岡伸通, 鈴木琢雄, 出水庸介, 石井明子. Evaluation of peptide-related impurities from nonstandard cyclic peptide by reversed phase chromatography. 日本薬学会年会要旨集(Web). 2024. 144th

Work history (2)：

2019/10 - 現在 National Institute of Health Sciences Division of Organic Chemistry
2017/07 - 現在国立医薬品食品衛生研究所有機化学主任研究官

Committee career (1)：

Awards (2)：

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