Research field (7):
Clinical pharmacy
, Physiology
, Cell biology
, Molecular biology
, Laboratory animal science
, Nutrition and health science
, Sports science
Research keywords (6):
サルコペニア
, 筋ジストロフィー
, Muscle metabolism
, Muscle fiber type
, Muscle stem cell
, Skeletal muscle
Research theme for competitive and other funds (9):
2021 - 2026 Multi-omics technologies to reveal common mechanism of dystrophic and sarcopenic skeletal muscles
2021 - 2024 Clarification of the mechanisms of muscle atrophy by RNA-binding proteins
2019 - 2022 Elucidation of pathogenesis of sarcopenia based on the plasticity of metabolism of skeletal muscle
2018 - 2021 Elucidation of the mechanisms of age-related muscle atrophy and development of novel therapies for sarcopenia
2016 - 2019 Elucidation of pathogenesis of sarcopenia based on the mechanism of metabolic changes of skeletal muscle
2018 - 2019 筋線維タイプ変換に基づいた新規筋萎縮治療法の開発
2015 - 2018 骨格筋細胞における代謝変換誘導因子の探索
2015 - 2016 骨格筋細胞における代謝変換メカニズムの解明
2009 - 2009 細胞移植治療を目指した骨格筋再生メカニズムの解析
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Papers (52):
Xuan Du, Hideyuki Nakanishi, Takashi Yamada, Yooksil Sin, Katsura Minegishi, Norio Motohashi, Yoshitsugu Aoki, Keiji Itaka. Polyplex Nanomicelle-Mediated Pgc-1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025. e2409065
Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Jacob Torrejon, Irene Basili, Flavia Bernardi, Patricia Benites Goncalves da Silva, Wanchen Wang, Owen Chapman, Liying Yang, et al. Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression. Developmental cell. 2024
Katsuhiko Kunitake, Norio Motohashi, Takafumi Inoue, Yutaka Suzuki, Yoshitsugu Aoki. Characterization of CD90/Thy-1 as a crucial molecular signature for myogenic differentiation in human urine-derived cells through single-cell RNA sequencing. Scientific reports. 2024. 14. 1. 2329-2329
Norio Motohashi, Katsura Minegishi, Yoshitsugu Aoki. Inherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein. Cell death & disease. 2023. 14. 10. 689-689
Nao Yamauchi, Katsuyuki Tamai, Iori Kimura, Azuma Naito, Nao Tokuda, Yuki Ashida, Norio Motohashi, Yoshitsugu Aoki, Takashi Yamada. High-intensity interval training in the form of isometric contraction improves fatigue resistance in dystrophin-deficient muscle. The Journal of physiology. 2023. 601. 14. 2917-2933