Kojima Yasushi

Affiliation and department：
Homepage URL (1)： https://cancer-c.pref.aichi.jp/site/folder5/1130.html

Research field (4)： Tumor biology , Pathobiochemistry , Physiology , Nutrition and health science

Research keywords (5)：がん , 悪液質 , 代謝 , 肝臓代謝 , プロテオーム解析

Research theme for competitive and other funds (11)：

2022 - 2025 Molecular mechanisms that maintain stemness in metastatic colorectal cancer
2021 - 2024 臨床応用を指向したがん悪液質病態解明
2023 - 肝臓NAD代謝を標的とした新規がん悪液質治療薬の開発研究
2018 - 2022 Molecular mechanisms and preventive/therapeutic targets of colon cancer metastasis
2017 - 2020 Roles of Dio2 (deiodinase, iodothyronine, type II) in colorectal tumorigenesis

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Papers (16)：

Yu Li, Teruaki Fujishita, Emi Mishiro-Sato, Yasushi Kojima, Yanqing Niu, Makoto Mark Taketo, Yuya Urano, Tomohisa Sakai, Atsushi Enomoto, Yoshihiro Nishida, et al. TGF-β signaling promotes desmoid tumor formation via CSRP2 upregulation. Cancer science. 2024. 115. 2. 401-411
Yasushi Kojima, Emi Mishiro-Sato, Teruaki Fujishita, Kiyotoshi Satoh, Rie Kajino-Sakamoto, Isao Oze, Kazuki Nozawa, Yukiya Narita, Takatsugu Ogata, Keitaro Matsuo, et al. Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia. Nature Communications. 2023
Sho Tabata, Yasushi Kojima, Takeharu Sakamoto, Kaori Igarashi, Ko Umetsu, Takamasa Ishikawa, Akiyoshi Hirayama, Rie Kajino-Sakamoto, Naoya Sakamoto, Ken-ichi Yasumoto, et al. L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis. Oncogene. 2023. 42. 16. 1294-1307
Teruaki Fujishita, Yasushi Kojima, Rie Kajino-Sakamoto, Emi Mishiro-Sato, Yasuhiro Shimizu, Waki Hosoda, Rui Yamaguchi, Makoto Mark Taketo, Masahiro Aoki. The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells. Cancer research. 2022. 82. 22. 4179-4190
Seisuke Tanigawa, Mitsugu Fujita, Chiami Moyama, Shota Ando, Hiromi Ii, Yasushi Kojima, Teruaki Fujishita, Masahiro Aoki, Hayato Takeuchi, Takumi Yamanaka, et al. Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model. Cancer gene therapy. 2021. 28. 12. 1339-1352

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MISC (33)：

Multi-omic analyses of changes in metabolic organs induced by cancer. 2024. 42. 4. 528-534
Abstract Proceedings of, h, Cancer Cachexia Conference, September, Edinburgh. Abstracts. Journal of Cachexia, Sarcopenia and Muscle. 2023. 14. S1. 3-59
小島康, 三城恵美, 武藤誠, 曽我朋義, 青木正博. A hallmark of hepatic metabolic alterations in cancer cachexia. 日本癌学会学術総会抄録集(Web). 2023. 82nd
青木正博, 青木正博, 曽我朋義, 小島康. がん悪液質における全身性代謝異常の解析. がんと代謝研究会プログラム&抄録集. 2023. 9th
青木正博, 小島康. 代謝 VI.代謝とオミクス解析がん悪液質のメタボロームおよびプロテオーム. 生体の科学. 2023. 74. 5

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Lectures and oral presentations (6)：

がん悪液質の代謝学的特徴としての肝臓ビタミンB関連酵素群の減少
(第11回日本サルコペニア・悪液質・消耗性疾患研究会 2024)
The landscape of systemic metabolic alterations in cancer cachexia
(The 7th Cancer Cachexia Conference, Edingburgh, Scotland 2023)
The landscape of systemic metabolic alterations in cancer cachexia
(The 7th JCA-AACR Special Joint Conference 2022)
Dual-omics reveals how;cancer cachexia;ransforms the;landscape of;liver;metabolism
(2021)
Cancer Cachexia
(2018)

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Education (2)：

2000 - 2004 京都大学大学院医学研究科博士課程
1992 - 1998 Hirosaki University

Professional career (1)：

PhD (Kyoto University)

Work history (5)：

2018/04 - 現在愛知県がんセンター研究所がん病態生理学分野主任研究員
2011/04 - 2018/03 愛知県がんセンター研究所分子病態学部主任研究員
2008/04 - 2011/04 英国マンチェスター大学博士研究員
2004/04 - 2008/03 京都大学大学院医学研究科遺伝薬理学教室
1998/05 - 2000/03 医療法人鉄蕉会亀田総合病院臨床研修医

Awards (1)：

2018/01 - 第1回がんと代謝研究会・若手の会優秀賞

Association Membership(s) (3)：

日本サルコペニア・悪液質・消耗性疾患研究会 , 日本分子生物学会 , 日本癌学会

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