Rchr
J-GLOBAL ID:202001018017221666   Update date: Sep. 17, 2024

Macpherson Tom

Macpherson Tom | Macpherson Tom
Affiliation and department:
Job title: Assistant Professor
Homepage URL  (1): http://www.protein.osaka-u.ac.jp/laboratories/adbancedbrainfunctions
Research field  (3): Animals: biochemistry, physiology, behavioral science ,  Psychiatry ,  Neuroscience - general
Research keywords  (5): Striatal Pathways ,  Psychiatric Disorders ,  Learning and Memory ,  Basal Ganglia ,  Neural Networks
Research theme for competitive and other funds  (6):
  • 2022 - 2025 Elucidation of the neural mechanism of strategic decision-making and the pathogenesis of psychiatric disorders
  • 2022 - 2025 戦略的な意思決定の神経機構と精神疾患病態の解明
  • 2021 - 2023 Investigation of nucleus accumbens subpopulations controlling reward and aversive learning
  • 2016 - 2021 Neural circuit mechanism of reward / goal-oriented behavior
  • 2016 - 2019 Neuronal circuit mechanisms in prepulse inhibition
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Papers (29):
  • Yoshiatsu Aomine, Yuto Shimo, Koki Sakurai, Mayuka Abe, Tom Macpherson, Takaaki Ozawa, Takatoshi Hikida. Sex-dependant differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice. bioRxiv. 2024
  • Yoshiatsu Aomine, Yoshinobu Oyama, Koki Sakurai, Tom Macpherson, Takaaki Ozawa, Takatoshi Hikida. Clozapine N-oxide, compound 21, and JHU37160 do not influence effortful reward-seeking behavior in mice. Psychopharmacology. 2023
  • 青峰 良淳, 櫻井 航輝, マクファーソン・トム, 小澤 貴明, 宮本 洋一, 米田 悦啓, 岡 正啓, 疋田 貴俊. アルコール関連行動異常の根底にある核-細胞質間輸送メカニズム. 日本神経精神薬理学会年会プログラム・抄録集. 2023. 53回. 154-154
  • 青峰 良淳, 櫻井 航輝, マクファーソン・トム, 小澤 貴明, 宮本 洋一, 米田 悦啓, 岡 正啓, 疋田 貴俊. アルコール関連行動異常の根底にある核-細胞質間輸送メカニズム. 日本神経精神薬理学会年会プログラム・抄録集. 2023. 53回. 154-154
  • Tom Macpherson, Claire I. Dixon, Jonathan Robertson, Marsha M. Sindarto, Patricia H. Janak, Delia Belelli, Jeremy J. Lambert, David N. Stephens, Sarah L. King. α4-containing GABAAreceptors on DRD2-neurons of the nucleus accumbens mediate instrumental responding for conditioned reinforcers, and its potentiation by cocaine. eNeuro. 2023. ENEURO.0236-23.2023
more...
MISC (4):
  • 柴田智弘, 米丸ひなの, 松本悠真, 中村萌, 岩本涼太郎, 尾山賀信, 櫻井航輝, MACPHERSON Tom, 疋田貴俊, 小澤貴明. The role of dopaminergic circuits on the enhancing effects of umami on salt seeking behavior in mice. 日本味と匂学会誌. 2021
  • Tom Macpherson, Takatoshi Hikida. Nucleus Accumbens D1 Receptor-Expressing Neurons Control Autoshaping Behavior. NEUROPSYCHOPHARMACOLOGY. 2017. 43. S287-S287
  • Takatoshi Hikida, Makiko Morita, Mahomi Kuroiwa, Tom Macpherson, Taichi Itou, Takahide Shuto, Naoki Sotogaku, Minae Niwa, Akira Sawa, Akinori Nishi. Social Isolated DISC1 Mutant Mice Displayed High Sensitivity to Chronic Cocaine Exposure and Rolipram Treatment. NEUROPSYCHOPHARMACOLOGY. 2015. 40. S249-S249
  • 疋田 貴俊, 森田 真規子, マクファーソン・トム, 伊藤 大一, 丹羽 美苗, 黒岩 真帆美, 澤 明, 西 昭徳. 社会的ストレス下においてDISC1変異マウスのコカイン感受性はPDE4により制御される(Cocaine-induced behavioral sensitization is regulated by PDE4 in social stressed DISC1 mutant mice). 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集. 2015. 37回・45回. 189-189
Lectures and oral presentations  (23):
  • Striatal mechanisms of discrimination learning and their dysfunction in psychiatric conditions
    (5th Annual Meeting of the UK-Japan Neuroscience Sympsoium 2023)
  • Striatal mechanisms of cue-guided decision-making and its dysfunction in schizophrenia model mice
    (43rd Annual Meeting of the Japan Neuroscience Society (JNS) 2023)
  • Cell-type-specific control of reward and aversive signaling in the Nucleus Accumbens
    (100th Annual Meeting of The Physiological Society of Japan Meeting 2023)
  • Striatal mechanisms of discrimination learning and their dysfunction in schizophrenia model mice
    (52nd Annual Meeting of the Society for Neuroscience (SfN) 2022)
  • Neural mechanisms in reward and aversion signaling
    (National Institute of Physiological Science (NIPS) Emotion Conference 2022)
more...
Education (2):
  • 2009 - 2014 Sussex University Neuroscience Behavioral and Clinical Neuroscience PhD
  • 2006 - 2009 Sussex University Neuroscience Psychology and Neuroscience
Professional career (1):
  • PhD (Neuroscience) (University of Sussex, UK)
Work history (5):
  • 2020 - 現在 Osaka University Institute for Protein Research Assistant Professor
  • 2018 - 2020 Osaka University Institute for Protein Research Specially Appointed Assistant Professor
  • 2017 - 2018 Kyoto University Graduate School of Medicine Postdoctoral Researcher
  • 2014 - 2017 Kyoto University Graduate School of Medicine JSPS Research Fellow
  • 2014 - 2014 Sussex University Neuroscience Postdoctoral Researcher
Association Membership(s) (3):
Society for Neuroscience ,  The Physiological Society of Japan ,  The Japan Neuroscience Society
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