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J-GLOBAL ID：202101011343736377 Update date: Mar. 03, 2025

Yano Fumiko

ヤノフミコ | Yano Fumiko

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Research theme for competitive and other funds (38)：

2024 - 2027 関節の恒常性維持と破綻における超硫黄分子の機能解明に基づく関節疾患治療の基盤構築
2024 - 2027 The mechanism of joint homeostasis in the coupling of articular cartilage and synovium
2023 - 2027 関節の恒常性を司る、滑膜と軟骨の連関制御機構の解明
2021 - 2026 The elucidation of joint homeostasis regulated by lubricin/Prg4-expressing cells using next generation sequencing technology
2022 - 2024 Development of effective tissue regeneration method based on single cell genomics of neural crest derived cell

2021 - 2024 Identification of pathogenesis, and development of therapeutic method for ossification of posterior longitudinal ligament recognized among inherited FGF23-related hypophosphatemic rickets/osteomalacia

2020 - 2024 Cdk6による骨格幹細胞G0/G1期制御機構の解明と骨再生医療に向けた基礎的検討

2020 - 2023 Notchシグナルによる関節幹細胞の維持機構の解明

2020 - 2023 変形性関節症におけるケモカインシグナル・フロントに着目した新規治療法の開発

2020 - 2023 神経根症の発症に関与する細胞群の解析と間葉系幹細胞による病態制御法の開発

2020 - 2023 自然免疫細胞と破骨細胞の骨免疫ネットワークの解明

2020 - 2023 Notchシグナルによる関節幹細胞の維持機構の解明

2020 - 2023 変形性関節症におけるケモカインシグナル・フロントに着目した新規治療法の開発

2019 - 2022 Prg4 を標的とした変形性関節症治療薬開発のための基盤研究

2018 - 2022 Prg4に立脚した、細胞・分子の多層的アプローチによる関節形成・維持機構の解明

2017 - 2020 Elucidation of tendon regeneration mechanism using achilles tendon resection model.

2017 - 2020 Wnt/b-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

2017 - 2019 靭帯骨化に関わる細胞集団とシグナル連関の解明

2016 - 2019 Basic research for the nanosheet to overcome serious clinical problems in the field of orthopedic surgery

2015 - 2018 Molecular Mechanisms of How Mechanical Stress Regulates Inflammation of Locomotive Organs

2015 - 2018 Mechanism of maintainace of articular chondrocyte by NF-kB signaling.

2015 - 2018 Transcription factor Hes1 modulates osteoarthritis development

2015 - 2018 Regulation of articular joint diseases by transcription factor family C/EBP

2015 - 2018 Identification of candidate compounds for the maintenance of SFZ in the articular cartilage through Prg4 induction

2016 - 2018 Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation(Fostering Joint International Research)

2014 - 2017 Development of chondrocyte differentiation method from human iPS cells

2013 - 2017 Runx1 contributes to articular cartilage maintenance through enhancement of cartilage matrix production and suppression of hypertrophic differentiation

2012 - 2016 Mechanism and its regulation of lipid rafts in the osteoclastic resorption of bone

2012 - 2015 a new disease-modifying osteoarthritis drug (DMOAD) candidate using a cell based screening system

2011 - 2014 Examination of hybrid bone grafts using nano DDS and artificial bones

2010 - 2013 The mechanism of transcriptional factor Runx1 in chondrogenic differentiation

2011 - 2013 Elucidation of tendon calcification inhibition mechanism of histamine H2-receptor antagonist

2009 - 2012 β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.

2009 - 2011 The elucidation of the between PTH and COX-2 in bone reconstruction

2009 - 2010 顎顔面領域軟骨欠損部に対する新たな軟骨再生法の確立

2008 - 2010 Strategic research for the identification of novel osteogenic small compounds and their application to bone regeneration

2008 - 2010 Clarification of interaction between β-catenin and PTH in osteogenesis for craniofacial bone regeneration

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Papers (71)：

Miki Maemura, Masanobu Morita, Seiryo Ogata, Yoichi Miyamoto, Tomoaki Ida, Kazuhiro Shibusaka, Soichiro Negishi, Masahiro Hosonuma, Taku Saito, Jun Yoshitake, et al. Supersulfides contribute to joint homeostasis and bone regeneration. Redox biology. 2025. 81. 103545-103545
Junya Miyahara, Yasunori Omata, Ryota Chijimatsu, Hiroyuki Okada, Hisatoshi Ishikura, Junya Higuchi, Naohiro Tachibana, Kosei Nagata, Shoichiro Tani, Kenichi Kono, et al. CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis. JCI insight. 2025. 10. 2
Kazuhiro Shibusaka, Soichiro Negishi, Nobuhiro Sakai, Youngkwan Kim, Hiroyuki Okada, Fumiko Yano. Synergistic effects of estrogen deficiency and articular disk derangement on condylar bone loss. Journal of Oral Biosciences. 2025. 100616-100616
Kenta Makabe, Hiroyuki Okada, Naohiro Tachibana, Hisatoshi Ishikura, Norihito Ito, Masaru Tanaka, Ryota Chijimatsu, Asuka Terashima, Fumiko Yano, Meiko Asaka, et al. Baricitinib ameliorates inflammatory and neuropathic pain in collagen antibody-induced arthritis mice by modulating the IL-6/JAK/STAT3 pathway and CSF-1 expression in dorsal root ganglion neurons. Arthritis research & therapy. 2024. 26. 1. 121-121
Sakura Uto, Atsuhiko Hikita, Daisuke Mori, Tomoaki Sakamoto, Fumiko Yano, Shinsuke Ohba, Taku Saito, Tsuyoshi Takato, Kazuto Hoshi. Subcutaneously Transplanted Fresh Cartilage in Allogeneic and Xenogeneic Immunocompetent Mouse. Tissue engineering. Part A. 2023. 29. 19-20. 541-556

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MISC (266)：

岡田寛之, 岡田寛之, 岡田寛之, 照井悠太, 小俣康徳, 小俣康徳, 関真秀, 谷彰一郎, 谷彰一郎, 谷彰一郎, et al. 運動器発のサブセルラーシーケンスで,細胞生物学の常識に挑む. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2023. 41st
岡田寛之, 岡田寛之, 岡田寛之, 照井悠太, 小俣康徳, 小俣康徳, 関真秀, 谷彰一郎, 谷彰一郎, 宮原潤也, et al. 1生細胞内シーケンスで多核巨細胞の遺伝子発現制御に挑む. 日本生化学会大会(Web). 2023. 96th
永田向生, 齋藤琢, 北條宏徳, 矢野文子, 岡田寛之, 大庭伸介, 鄭雄一, 田中栄. Runx2とRunx3は手術誘導された変形性関節症において関節軟骨に異なる役割を果たす. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2023. 41st
宮原潤也, 小俣康徳, 寺島明日香, 千々松良太, 岡田寛之, 矢野文子, 鈴木穣, 田中栄, 齋藤琢. The pathophysiology and symptoms of knee osteoarthritis are associated with gene expression and subsets of synovial cells. 日本軟骨代謝学会プログラム・抄録集. 2023. 35th
Naohiro Tachibana, Ryota Chijimatsu, Hiroyuki Okada, Yuki Taniguchi, Takeshi Oichi, Hideki Nakamoto, So Kato, Toru Doi, Yoshitaka Matsubayashi, Yasushi Oshima, et al. Rspo2/Prg4-Positive Cells Contribute to Ligament/Tendon Homeostasis Through Suppression of Ectopic Endochondral Ossification. JOURNAL OF BONE AND MINERAL RESEARCH. 2022. 37. 1-1

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Patents (2)：

Professional career (1)：

Ph.D. (Medicine) (The University of Tokyo)

Work history (4)：

2025/03 - 現在 Showa University Showa University Research Administration Center: SURAC
2021/07 - 2025/02 Showa University School of Dentistry
2018/04 - 2021/06 東京大学医学部附属病院ティッシュエンジニアリング部整形外科・脊椎外科骨・軟骨再生医療講座特任准教授
2016/12 - 2020/10 Harvard Medical School, Boston Children's Hospital Genetics, Orthopedic Research Center JSPS Scientist for Joint International Research

Committee career (2)：

2018 - 現在日本再生医療学会代議員
2013 - 2015 IBMS(International Bone & Mineral Society) Young Investigator Committee

Association Membership(s) (4)：

The American Society for Bone Mineral Research , 日本口腔外科学会 , 日本再生医療学会 , 日本骨代謝学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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