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J-GLOBAL ID：202201009160990390 Update date: Aug. 07, 2024

Takayama Eiji

タカヤマエイジ | Takayama Eiji

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Affiliation and department：
Job title： Associate Proffesor

Research field (1)： Applied biochemistry

Research keywords (2)：音声病態 , T細胞免疫

Research theme for competitive and other funds (23)：

2024 - 2027 フッ素徐放性Zn-Alハイドロタルサイトの創出と新規多機能歯科材料としての応用評価
2022 - 2025 Modification of the intercellular network of immune cells in tumor microenvironment by sedatives and anesthetics.
2022 - 2025 腸内環境改善と炎症制御による新たなサルコペニア肥満治療の開発
2021 - 2024 ハイドロタルサイトの化学的特性を応用した新たな多機能型歯科用セメントの創出
2021 - 2024 化学療法抵抗性の頭頸部腫瘍を伴う患者でニボルマブが化学療法を著効する仕組みの解明

2020 - 2023 Dental clinical application fo induction odontoblastic differentiation mechanism in Dental Pulp Stem Cells

2020 - 2023 口腔扁平上皮癌の悪性化に伴う間葉系および骨髄系間質細胞の免疫制御と調節因子の変化

2019 - 2022 ケトン食が抗腫瘍免疫能を賦活化し、腫瘍の成長・予後を改善するメカニズム

2018 - 2022 Influence of anesthetics on host immunity through cancer microenvironment

2018 - 2022 Effect of low-dose / low-dose-rate radiation on systemic immunity of disease model animals

2017 - 2020 Repairing of radiation-induced tissue damage by extracellular vesicles that mediate interaction of tissue-specific stem cells

2017 - 2020 Clarification of metastasis development mechanism in oral cancer stem cell

2017 - 2020 Effect of immersion in phosphate buffer on the surface charge and protein adsorption properties of titanium dental implant materials

2017 - 2020 Mechanisms of immune modulation regulated by factors from OSCC cells on the development of acquiring metastatic potential to regional lymph nodes

2015 - 2018 Development of Technology for Therapeutic Effect Follow-up by Voice Pathophysiological Analyzing

2015 - 2018 Antitumor immunities with low dose / low dose rate radiation on murine model with oral squamous cell carcinoma

2015 - 2018 The immunomodulatory effects of anesthetics in cancer microenvironment leading to cancer malignancy

2014 - 2017 Cellular response to the novel carbonate apatite bone substitute activating bone regeneration

2014 - 2017 Modulatory effect of fluvastatin upon immune suppression regulated by mesenchymal stromal cells and oral squamous cell carcinoma cells

2012 - 2015 Study for subsets of lymphocyte which take a role on the mechanism that mesenchymal stem cells derived from dental pulp reduce graft versus host disease

2011 - 2014 Regulatory effect of the TLR/TACI-MyD88 signaling pathway on immune responses associated with the homing of IgA-producing B cells into salivary glands

2011 - 2013 Prognosis of oral squamous cell carcinoma patients using gene expression profile and immunological status.

2011 - 2013 Basic research for drug discovery: Modulation of early chondrogenesis by the interaction of CCN2 and CCN3

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Papers (102)：

Megumi Ando, Moe Takahashi, Masako Mizuno-Kamiya, Hiroe Morimoto-Ito, Kumiko Ikeno, Kyohei Ueno, Eiji Takayama, Harumi Kawaki, Genjiro Nakamura, Yasunori Muramatsu, et al. Enhanced production of IL-2 from anti-CD3 antibody-stimulated mouse spleen cells by caffeic acid phenethyl ester, a major component of Chinese propolis. Journal of oral biosciences. 2023. 65. 4. 386-394
高橋萌, 神谷真子, 池野久美子, 上野恭平, 梅村直樹, 高山英次, 川木晴美, 中村源次郎, 村松泰徳, 近藤信夫. カフェイン酸フェネチルエステル(CAPE)による、抗CD3抗体刺激マウス脾細胞におけるIL-2産生の促進を介したIL-4およびIL-10の活性化. Journal of Oral Biosciences Supplement. 2023. 2023. [P2-23]
神谷真子, 高山英次, 川木晴美, 梅村直己, 上野恭平, 高橋萌, 村松泰徳, 近藤信夫. マウス刺激脾細胞のインターロイキン-2およびインターロイキン-10産生におよぼすベンゾジアゼピン受容体リガンドの効果. Journal of Oral Biosciences Supplement. 2023. 2023. [P3-22]
ラハマン・シィファ, 鶴田はねみ, 池野久美子, 上野恭平, 梅村直己, 高山英次, 川木晴美, 中村源次郎, 二階堂徹, 近藤信夫. ブラジル産グリーンプロポリス(BGP)によるマウス脾細胞のIL-2産生促進作用に対するカフェイン酸フェネチルエステル(CAPE)の抑制作用. Journal of Oral Biosciences Supplement. 2023. 2023. [P1-13]
Masakazu Higuchi, Mitsuteru Nakamura, Shuji Shinohara, Yasuhiro Omiya, Takeshi Takano, Daisuke Mizuguchi, Noriaki Sonota, Hiroyuki Toda, Taku Saito, Mirai So, et al. Detectionof Major Depressive Disorder Based on a Combination of Voice Features: An Exploratory Approach. International journal of environmental research and public health. 2022. 19. 18

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MISC (25)：

安藤恵, 神谷真子, 池野久美子, 上野恭平, 梅村直樹, 高山英次, 川木晴美, 中村源次郎, 近藤信夫. カフェイン酸フェネチルエステル(CAPE)による抗CD3抗体刺激マウス脾細胞のサイトカイン産生調節機構(Regulatory mechanism of cytokine productions from anti CD3 antibody-stimulated mouse spleen cells by caffeic acid phenethyl ester(CAPE)). Journal of Oral Biosciences Supplement. 2022. 2022. 207-207
神谷真子, 高山英次, 川木晴美, 梅村直己, 上野恭平, 高橋萌, 智原栄一, 村松泰徳, 近藤信夫. マウス刺激脾細胞のインターロイキン-2産生におよぼすミダゾラムの効果(Effect of midazolam on the interleukin-2 production in stimulated mouse splenocytes). Journal of Oral Biosciences Supplement. 2022. 2022. 210-210
高橋萌, 神谷真子, 池野久美子, 上野恭平, 梅村直樹, 高山英次, 川木晴美, 中村源次郎, 村松泰徳, 近藤信夫. Artepillin CおよびCaffeic acid phenethyl ester(CAPE)によるIL-2産生促進作用の比較(Comparison of enhanced IL-2 productions from anti-CD3 antibody-stimulated mouse spleen cells treated with Artepillin C or caffeic acid phenethyl ester(CAPE)). Journal of Oral Biosciences Supplement. 2022. 2022. 374-374
神谷真子, 松並晃弘, 安藤恵, 上野恭平, 梅村直己, 川木晴美, 高山英次, 村松泰徳, 智原栄一, 近藤信夫. 癌組織における免疫抑制環境の形成におよぼすミダゾラムの影響. Journal of Oral Biosciences Supplement. 2020. 2020. 228-228
安藤恵, 松並晃弘, 神谷真子, 池野久美子, 上野恭平, 梅村直己, 川木晴美, 高山英次, 中村源次郎, 近藤信夫. 腫瘍微小環境における間質細胞の免疫抑制作用に対するブラジル産プロポリス(BP)の作用. Journal of Oral Biosciences Supplement. 2020. 2020. 231-231

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Lectures and oral presentations (160)：

口腔扁平上皮癌細胞は薬剤耐性獲得に伴い発現したABCG2はがん幹細胞の特長の維持に関与する(Maintenance of cancer stem cell characteristic in oral squamous cell carcinoma cells by the expression of ABCG2 associated with acquired drug resistance)
(Journal of Oral Biosciences Supplement 2021)
マウス刺激脾細胞のIL-10産生におよぼすミダゾラムの効果(Effect of midazolam on the IL-10 production in stimulated mouse splenocytes)
(Journal of Oral Biosciences Supplement 2021)
陰イオン交換により作製した異なるホウ素濃度のS-PRGフィラー抽出液のヒト歯髄由来幹細胞への影響(Effect of S-PRG filler eluate with different boron concentrations prepared by anion exchange on human dental pulp-derived stem cells)
(Journal of Oral Biosciences Supplement 2021)
ブラジル産プロポリスによる抗CD3刺激脾細胞のIL-2産生促進作用の解析(Mechanism of enhanced production of IL-2 from anti CD3-stimulated mouse spleen cells by Brazilian propolis)
(Journal of Oral Biosciences Supplement 2021)
ShikoninはCD44存在下でAKT-mTORを介して歯髄幹細胞を象牙芽細胞へと分化誘導する
(Journal of Oral Biosciences Supplement 2020)

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Education (5)：

1991 - 1995 Kyoto University
1989 - 1991 東京大学大学院理学系研究科
1988 - 1989 Kyoto University
1986 - 1988 京都工芸繊維大学大学院繊維学研究科
1982 - 1986 Kyoto Institute of Technology

Work history (2)：

2008/11 - 現在 Asahi University School of Dentistry
1995/07 - 2008/10 防衛省防衛医科大学校

Association Membership(s) (5)：

ヒト細胞学会 , 癌学会 , 免疫学会 , 分子生物学会 , 生化学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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