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J-GLOBAL ID：202401017726571703 Update date: Apr. 18, 2025

Oki Eiji

オキエイジ | Oki Eiji

Affiliation and department：
Job title： Associate Professor
Research theme for competitive and other funds (50)：

2024 - 2027 NK様活性をもつ細胞療法による大腸癌に対する画期的な周術期治療法の開発
2023 - 2026 治療抵抗性を獲得した食道癌への局所免疫を応用した革新的治療法の開発
2023 - 2026 メタボロゲノミクス解析による胃癌術後腸内細菌叢の解明と術後栄養障害の革新的治療法の開発
2022 - 2026 Development of label free separation and recovery technology for circulating tumor cells
2022 - 2025 直腸癌の個別的リスク評価を目的とした人工知能MRI解析アルゴリズムの確立

2022 - 2025 機械学習(AI)を用いた画像診断で同定困難な大腸癌微小肝転移の高精度同定法の開発

2022 - 2024 機能獲得型変異p53が制御する癌幹細胞化の解明と治療戦略の確立

2021 - 2024 バイオマーカーおよびプロテアソーム阻害剤を用いた新たなイリノテカン療法の開発

2020 - 2023 Establishment of new selection system for adjuvant chemotherapy of colorectal cancer

2020 - 2023 Elucidation of oxidative repair function involved in esophageal carcinogenesis mechanism and development of novel therapy for prevention of cancer invasion

2020 - 2023 Innovative Therapies Targeting Increased Susceptibility to Chemoradiotherapy for Esophageal Cancer

2019 - 2022 Development of a new treatment method aimed at enhancing the effect of irinotecan therapy for gastrointestinal cancer

2018 - 2021 Molecular mechanism of carcinogenesis of head and neck and esophagus induced by cigarette smoking and alcohol drinking: Aiming to establishment of personalized treatment strategy

2018 - 2021 Exploring an effective irinotecan treatment by way of biomarker and a new remedy

2018 - 2020 RNA involvement in the process of chemotherapy-induced DNA replication stress

2017 - 2020 Molecular mechanism of therapy-induced senescence caused by replicative stress

2017 - 2020 New classification of gastric cancer based on genome analysis for precision medicine

2017 - 2020 Molecular mechanisms of cytokinesis completion and cell fate decision after cytokinesis failure

2015 - 2020 Development of Innovative Treatment Targeting the Sphere Formation Mechanism Involving Cancer Stem Cells

2016 - 2019 Elucidation of molecular mechanism of resistance to chemoradiotherapy of esophageal cancer and development of new treatment focusing on cancer stem cells

2016 - 2019 Elucidation of molecular mechanisms of and development of combined therapy with immune checkpoint inhibitors for digestive tract cancer

2016 - 2019 The development of genomically stability and chromosomal instability and the molecular mechanism of peritoneal metastases for gastric cancer

2016 - 2019 Molecular mechanism of the cancer odor and development of the new cancer diagnostic system

2016 - 2018 Development of the the innovative treatment and the proposal of the Self-niche hypothesis in refractory cancer

2015 - 2018 Research and development of measuring systems of breast cancer by mimicking olfactory systems of nematode C. elegans

2015 - 2018 Research and development of innovative biological tissue bonding technology by laser transmission welding method using biomaterial

2015 - 2018 Molecular mechanism of development and progression of upper aerodigestive tract cancer induced by cigarette smoking and alcohol drinking

2015 - 2018 Strategy of anti-cancer therapy for gastrointestinal cancers targeting non-oncogenic addiction

2015 - 2018 Clinical application to significance and growth control of the chromosome instability in carcinogenesis, the progress of gastrointestinal cancer

2015 - 2017 molecular analysis of mechanisms for improving glucose tolerance ability with bariatric surgery

2014 - 2017 Investigation of chemoradiation sensitivity based on the DNA repair mechanism in esophageal carcinoma

2014 - 2016 Biomarker research for PD-1 inhibitor and new combination therapy anti-PD-1 and chemotherapeutic agents

2013 - 2016 Novel molecular targeting strategy against chromosomal maintenance factor FANCJ

2013 - 2016 Chromosomal dynamics and development of novel therapy in gastrointestinal tract cancer

2013 - 2016 Establishment of the new therapy based on inflammatory mediator and DNA methylation in colorectal cancer

2013 - 2016 The analysis of the spindle checkpoint protens and the application to the new molecular targetted therapy for colorectal cancer.

2013 - 2016 The study for molecular mechanism of drug resistance and development of new treatment which aimed at colorectal cancer stem cell.

2012 - 2016 DNA mismatch repair gene analysis predicts the response to anticancer drug sensitivity in gastrointestinal cancers for tailored therapy.

2014 - 2015 ヒト癌免疫編成機構の分子機序解明と免疫合成致死を誘導する革新的免疫療法の研究開発

2012 - 2015 Pre-clinical application of an innovative therapy, "BioKnife", to malignant pleural mesothelioma

2012 - 2015 The study of the sensitivity for gastric cancer neoadjuvant chemotherapy raleting to cancer stem cells

2012 - 2015 Molecular mechanism of esophageal carcinogenesis induced by cigarette smoking and alcohol drinking and its clinical application

2012 - 2015 The development of the high precision navigation system of sentinel node in gastrointestinal cancer in an open MRI operating theater

2008 - 2010 Clarification of the molecular mechanism of Japanese triple negative breast cancers and the development of innovative therapy for them

2007 - 2008 New Molecular target of cancer cell migration in breast cancer patients.

2007 - 2008 Analysis of EGFR ligandpathway in gastric cancer and as a target for anti-cancer drug discovery

2006 - 2008 Mechanism of multicentric carcinogenesis and prevention of the second cancer in the upper aerodigestive induced by cigarette smoking and alcohol drinking

2005 - 2006 Prediction of chemoradiosensitivity of esophageal cancer

2005 - 2006 PTEN/ATK/PI3Kシグナル経路の制御による消化器癌の新しい薬物治療の開発

2001 - 2004 Detection and clinical application of circulating cancer cells, using highy pricise cancer cell determination system

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Papers (564)：

Yasushi Tanaka, Qingjiang Hu, Tetsuro Kawazoe, Hirotada Tajiri, Ryota Nakanishi, Yoko Zaitsu, Yuichiro Nakashima, Mitsuhiko Ota, Eiji Oki, Yoshinao Oda, et al. The clinical significance of signal regulatory protein alpha expression in the immune environment of gastric cancer. International journal of clinical oncology. 2025. 30. 2. 330-339
Yasushi Tanaka, Ryota Nakanishi, Shota Sato, Akihiko Otake, Keiichiro Ryujin, Shinichiro Ikeda, Yuho Ebata, Tomoya Harima, Keita Natsugoe, Takayuki Yoshiyama, et al. RAS mutant transverse colon cancer with multiple liver metastases achieving long-term disease-free survival with postoperative maintenance therapy with aflibercept + FOLFIRI and four repeated radical resections: a case report. Surgical case reports. 2024. 10. 1. 231-231
Takeshi Wakasa, Kentaro Nonaka, Akihito Harada, Yasuyuki Ohkawa, Chie Kikutake, Mikita Suyama, Takashi Kobunai, Kenta Tsunekuni, Kazuaki Matsuoka, Yuki Kataoka, et al. The anti-tumor effect of trifluridine via induction of aberrant mitosis is unaffected by mutations modulating p53 activity. Cell death discovery. 2024. 10. 1. 307-307
Masaki Mori, Satoshi Hirano, Kenichi Hakamada, Eiji Oki, Shigeo Urushidani, Ichiro Uyama, Masatoshi Eto, Yuma Ebihara, Kenji Kawashima, Takahiro Kanno, et al. Clinical practice guidelines for telesurgery 2022. Surgery Today. 2024
Yasuhiro Haruta, Yuichiro Nakashima, Tetsuo Ikeda, Eiji Oki, Tomoharu Yoshizumi. Evaluation of gastric tube blood flow by multispectral camera and fluorescence angiography. Surgery open science. 2024. 19. 87-94

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MISC (6)：

Yuka Inoue, Nami Yamashita, Eriko Tokunaga, Hiroyuki Kitao, Kimihiro Tanaka, Hiroki Ueo, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara. Biological significance of the wild-type p53-induced phosphatase 1(Wip1) expression in invasive breast cancer. CANCER RESEARCH. 2016. 76
E. Oki, Y. Emi, Y. Miyamoto, Y. Ogata, S. Tokunaga, K. Shirabe, T. Beppu, S. Uchida, M. Takatsuki, M. Sakoda, et al. Comparison of two Phase II trials of mFOLFOX6 plus bevacizumab (KSCC0802) and SOX (S-1 and oxaliplatin) plus cetuximab (KSCC1002): First line chemotherapy in colorectal cancer patients with initially unresectable or not optimally resectable liver only metastases. EUROPEAN JOURNAL OF CANCER. 2015. 51. S378-S378
Yuji Miyamoto, Yasunori Emi, Shoji Tokunaga, Toru Beppu, Yoshihiro Kakeji, Eiji Oki, Hiroshi Saeki, Shinichiro Mori, Masafumi Inomata, Yoshito Akagi, et al. Liver resectability following S-1+L-OHP with cetuximab as the first-line treatment of unresectable liver limited metastases from KRAS exon 2 wild-colorectal cancer in Japanese patients (KSCC 1002). JOURNAL OF CLINICAL ONCOLOGY. 2015. 33. 3
Hiroyuki Kawano, Hiroshi Saeki, Hiroyuki Kitao, Koji Ando, Shuhei Ito, Eiji Oki, Masaru Morita, Yoshihiko Maehara. Relationship of global DNA hypomethylation-mediated chromosomal instability to the initiation and progression of esophageal squarnous cell carcinoma. JOURNAL OF CLINICAL ONCOLOGY. 2014. 32. 15
Tetsuya Kusumoto, Koji Ando, Satoshi Ida, Yasue Kimura, Hiroshi Saeki, Eiji Oki, Masaru Morita, Yoshihiko Maehara. S-1/docetaxel compared with the other standard S-1 based regimens as a first-line chemotherapy for patients with advanced gastric cancer. JOURNAL OF CLINICAL ONCOLOGY. 2013. 31. 15

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Patents (4)：

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