Rchr
J-GLOBAL ID：200901007041217297
Update date: Jul. 08, 2022
MOTOHASHI Shigeyasu
モトハシ シゲヤス | MOTOHASHI Shigeyasu
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Affiliation and department：
Nihon University School of Pharmacy Department of Pharmacy
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Detailed information
Job title：
Professor
Research field (4)：
Pharmaceuticals - chemistry and drug development
, Synthetic organic chemistry
, Bioorganic chemistry
, Structural/physical organic chemistry
Research keywords (4)：
Sulfoxides
, Optical activity
, Asymmetric Synthesis
, Organic Chemistry
Papers (45)：
Daijiro Kobayashi, Motofumi Miura, Masaharu Toriyama, Shigeyasu Motohashi. Stereoselective Synthesis of Secondary and Tertiary Propargylic Alcohols Induced by a Chiral Sulfoxide Auxiliary. Tetrahedron Letters. 2019. 60. 120-123
Hiroyuki Yoda, Toshimitsu Nakayama, Motofumi Miura, Masaharu Toriyama, Shigeyasu Motohashi, Takashi Suzuki. Vitamin K3 derivative induces apoptotic cell death in neuroblastoma via downregulation of MYCN expression. Biochemistry and Biophysics Reports. 2019. 20. 100701
Motofumi Miura, Toshinori Nakakita, Masaharu Toriyama, Shigeyasu Motohashi. An Efficient Synthesis of exo/endo-Hydroxylated Cyclohexenones by Thiol/Amine-Mediated Tandem Aldol-[2,3]-Sigmatropic Rearrangement: Amine-Dependent Complementary Regioselectivity. ASIAN JOURNAL OF ORGANIC CHEMISTRY. 2018. 7. 5. 883-887
Miko Imai, Kaname Hashizaki, Aiko Yanagi, Hiroyuki Taguchi, Yoshihiro Saito, Shigeyasu Motohashi, Makiko Fujii. Skin Permeation of Testosterone from Viscoelastic Lecithin Reverse Wormlike Micellar Solution. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2016. 39. 4. 532-539
Shigeyasu Motohashi, Kouichi Nagase, Toshinori Nakakita, Takeshi Matsuo, Yoshikazu Yoshida, Takashi Kawakubo, Motofumi Miura, *, Masaharu Toriyama, and Mikhail V. Barybin. Stereochemically Controlled Asymmetric 1,2-Reduction of Enones Mediated by a Chiral Sulfoxide Moiety and a Lanthanum(III) Ion. The Journal of Organic Chemistry. 2011. 76. 10. 3922-3936
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MISC (8)：
Toshinori Nakakita, Motofumi Miura, Masaharu Toriyama, Shigeyasu Motohashi, Mikhail V. Barybin. Remote induction of stereoselective 1,2-addition of aryl Grignard reagents to beta-sulfinyl enones. TETRAHEDRON LETTERS. 2014. 55. 5. 1090-1092
Jie Zhang, Ryosuke Koike, Ayako Yamamoto, Motohiko Ukiya, Makoto Fukatsu, Norihiro Banno, Motofumi Miura, Shigeyasu Motohashi, Harukuni Tokuda, Toshihiro Akihisa. Glycosidic Inhibitors of Melanogenesis from Leaves of Passiflora edulis. CHEMISTRY & BIODIVERSITY. 2013. 10. 10. 1851-1865
Miko Imai, Kaname Hashizaki, Hiroyuki Taguchi, Yoshihiro Saito, Shigeyasu Motohashi. A new reverse worm-like micellars sysytem from a lecithin, multivalent carboxylic acid and oil mixture. Jouranal of Colloid and Interface Science. 2013. 403. 77-83
Katsuhiko Konno, Motofumi Miura, Masaharu Toriyama, Shigeyasu Motohashi, Rie Sawamura, Wataru Watanabe, Hiroki Yoshida, Masahiko Kato, Ryuichi Yamamoto, Ken Yasukawa. Antiviral activity of diarylheptanoid stereoisomers against respiratory syncytial virus in vitro and in vivo. Journal of Natural Medicines. 2013. 67. 773-781
Tomohisa Hayashi, Ikuo Sakurada, Kensuke Honda, Shigeyasu Motohashi, Kazuo Uchikura. Electrochemical Detection of Sugar-related Compounds Using Boron-doped Diamond Electrodes. ANALYTICAL SCIENCES. 2012. 28. 2. 127-133
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Books (5)：
薬がわかる構造式集
廣川書店 2013
本格対応 毒物劇物取扱者試験 基礎化学、毒、劇物の性状・貯蔵・取扱方法
じほうビジネスサービス 2013
有機医薬品化学 ターゲット分子の合成
廣川書店 2011
無機化合物・錯体 -無機化合物の基礎- 第2版
廣川書店 2010
無機化合物・錯体-生物無機化学の基礎-
廣川書店 2005
Lectures and oral presentations (47)：
4-Tolylsulfinylheptandioneを用いた不斉アルドール/2,3-シグマトロピー転位反応の検討
(第63回日本薬学会関東支部会 2019)
触媒量のCsFによって加速される2-hydroxychalconeのHetero-Michael反応
(第63回日本薬学会関東支部会 2019)
キラルスルホキシドを用いた立体選択的プロパルギルアルコール類の合成
(日本薬学会第139年会 2019)
フッ化物イオン触媒を用いたHetero-Michael 反応による効率的なFlavanone 骨格の合成
(日本薬学会第139年会 2019)
光学活性スルホキシドを用いた不斉Aldol/2,3- シグマトロピー転位反応の検討
(日本薬学会第139年会 2019)
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Education (1)：
- 1976 Nihon University Faculty of Science and Engineering 薬学科
Association Membership(s) (4)：
アメリカ化学会(American Chemical Society)
, 日本化学会
, 日本薬学会
, 日本生薬学会
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