Rchr
J-GLOBAL ID：200901008577138884   Update date: Jan. 28, 2026

Nagata Tetsuya

ナガタ テツヤ | Nagata Tetsuya
Affiliation and department：
Institute of Science Tokyo NucleoTIDE and PepTIDE Drug Discovery Center, Institute of Research

About Institute of Science Tokyo NucleoTIDE and PepTIDE Drug Discovery Center, Institute of Research


Job title： Professor
Research field  (1)： Neurology
Research keywords  (5)： 血液脳関門 ,  遺伝子治療 ,  筋疾患 ,  神経変性疾患 ,  核酸医薬
Research theme for competitive and other funds  (11)：
  • 2022 - 2026 Development of innovative target organ-specific oligonucleotide therapy
  • 2021 - 2024 羊膜間葉系幹細胞由来エクソソームを利用した次世代型脳梗塞治療法の確立
  • 2019 - 2022 Development of innovative nucleic acid therapy enabling any gene control in cardiac and skeletal muscle
  • 2017 - 2022 血液脳関門通過性ヘテロ核酸の開発
  • 2016 - 2019 全身投与による中枢神経制御を可能とする新規核酸医薬の開発
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Papers (110)：
  • Sakino Matsuda-Kawabata, Tetsuya Nagata, Mitsugu Yanagidaira, Kensuke Ihara, Masaki Ohyagi, Hidetoshi Kaburagi, Kie Yoshida-Tanaka, Asuka Sasaki, Aya Abe, Satoe Ebihara, et al. Heteroduplex oligonucleotide technology boosts gene knockdown in cardiac and skeletal muscles. Nucleic Acids Research. 2026
  • Mitsugu Yanagidaira, Tetsuya Nagata, Juri Hasegawa, Takashi Ishii, Satoe Ebihara, Makiko Nawa, Takanori Yokota. Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection. Nature Communications. 2025
  • Hiroyuki Chaya, Mitsuru Naito, Kazuko Toh, Naoki Yamada, Kaori Taniwaki, Yurugi Kinoshita, Shigeto Fukushima, Katsura Minegishi, Yoshitsugu Aoki, Tetsuya Nagata, et al. Enhanced Accumulation of Heteroduplex Oligonucleotides in Dystrophin-Deficient Skeletal Muscles by Single Oligonucleotide-Loaded Unit Polyion Complexes. ACS omega. 2025. 10. 31. 34363-34371
  • Yukitake Yoshioka, Syunsuke Yamamoto, Kosuke Kusamori, Miyu Nakayama, Hisashi Fujita, Akihiko Goto, Shinji Iwasaki, Tetsuya Nagata, Shoko Itakura, Hiroyuki Kusuhara, et al. Pharmacokinetics and protein binding of cholesterol-conjugated heteroduplex oligonucleotide. Journal of controlled release : official journal of the Controlled Release Society. 2025. 380. 787-799
  • Ryo Iwase, Taro Ishiguro, Rintaro I Hara, Tetsuya Nagata, Takanori Yokota. G-Quadruplex-Based Splice Switching as a Therapeutic Approach in Duchenne Muscular Dystrophy. ACS chemical biology. 2025. 20. 3. 670-679
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MISC (307)：
  • 石井光太郎, 板倉祥子, 草森浩輔, 山本俊輔, 岩崎慎治, 楠原洋之, 永田哲也, 永田哲也, 横田隆徳, 横田隆徳, et al. Regulation of the cellular uptake and in vivo pharmacokinetics of antisense oligonucleotides through protein binding. 日本薬剤学会年会講演要旨集(CD-ROM). 2025. 40th
  • 木曾由梨香, 福田翔一郎, 向井英史, 田原強, 大谷環樹, 毛利浩太, 北原育美, 松尾礼子, 桑原宏哉, 永田哲也, et al. Evaluation of the usefulness of Nose-to-Brain Delivery Nanoparticles and Ionic Liquids for Nose-to-Brain Delivery of Heteroduplex Nucleic Acids. 日本薬学会年会要旨集(Web). 2025. 145th
  • 天野晶子, 三條伸夫, 荒木亘, 永田哲也, 永田哲也, 中木戸誠, 中木戸誠, 松原悦朗, 松原悦朗, 安楽泰孝, et al. Aβ oligomer特異的フラグメント抗体の投与による認知機能及び病態改善効果の検討. Dementia Japan. 2024. 38. 4
  • 勝山真帆, 吉岡耕太郎, SU Lei Mon Su, JIA Chunyan, 田中規恵, 原(岩田)倫太朗, 永田哲也, 横田隆徳. Validation of Mechanisms for Mitigating Central Nervous System Toxicity of Antisense Oligonucleotides Using Heteroduplex Oligonucleotide Technology. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2024. 9th
  • 黒田隆之, 吉岡耕太郎, LEI MON Su Su, 佐藤久美子, 磯貝恵理子, 勝山真帆, 吉田(田中)規恵, 原(岩田)倫太朗, 山口卓男, 永田哲也, et al. Novel chemical modification mitigates late-onset neurotoxicity of antisense oligonucleotide via intrathecal route. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2024. 9th
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Patents (72)：
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Lectures and oral presentations  (8)：
  • デュシャンヌ型筋ジストロフィーに対する核酸医薬
    (第38回日本神経治療学会学術大会 2020)
  • BBB-penetrating heteroduplex oligonucleotide
    (2020)
  • 核酸医薬品開発の現状
    (BioJapan 2018)
  • Development of oligonucleotide therapies for neurodegenerative disease.
    (2018)
  • ヘテロ核酸による遺伝子発現抑制
    (2018)
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Education (2)：
  • - 1999 Graduate School, Division of Medical Sciences, Tohoku University
  • - 1994 Faculty of Medicine, Tohoku University
Professional career (1)：
  • M.D., Ph.D. (Tohoku University)
Work history (7)：
  • 2022/08 - 現在 Tokyo Medical and Dental University NucleoTIDE and PepTIDE Drug Discovery Center, Institute of Research Professor
  • 2018/04 - 2022/07 Tokyo Medical and Dental University
  • 2014/11 - 2018/03 Tokyo Medical and Dental University Department of Neurology and Neurological Science Senior Assistant Professor
  • 2009 - 2014/10 National Center of Neurology and Psychiatry National Institute of Neuroscience Section cheif
  • 2008 - 2009 Okayama University Department of Neurology Assistant professor
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Committee career (4)：
  • 2019/04 - 現在 日本核酸医薬学会 幹事
  • 2015/04 - 現在 日本核酸医薬学会 評議員
  • - 現在 日本神経学会 代議員
  • - 現在 日本神経治療学会 評議員
Awards (3)：
  • 2022/11 - Japanese Society of Neurological Therapeutics The Best Activity Award 神経・筋疾患に対する核酸医薬品の開発への取り組み
  • 2022/10 - Oligonucleotide Therapeutics Society 2022 Paper of the Year Award - Basic Research Category Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS
  • 2020/11 - 日本核酸医薬学会 特別賞 国内初のデュシェンヌ型筋ジストロフィーに対する核酸医薬品の開発
Association Membership(s) (8)：
Society for Neuroscience ,  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM ,  THE JAPAN NEUROSCIENCE SOCIETY ,  Oligonucleotide Therapeutics Society ,  日本神経治療学会 ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  日本核酸医薬学会 ,  JAPANESE SOCIETY OF NEUROLOGY
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