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J-GLOBAL ID：200901022350771168 Update date: Apr. 09, 2025

Yasui Hiroshi

ヤスイヒロシ | Yasui Hiroshi

Affiliation and department：
Job title： Specially Appointed Professor
Other affiliations (4)：

The University of Tokyo Division of Cell Signaling and Molecular Medicine, The Institute of Medical Science Visiting Associate Professor
The University of Tokyo Department of Hematology/Oncology, The Institute of Medical Science Research Hospital, Visiting senior assistant professor
Mitsui Memorial Hospital Department of Hematology A part-time physician
Kawasaki Municipal Tama Hospital Development of Hematology A part-time physician

Homepage URL (1)： https://www.marianna-u.ac.jp/houjin/staff/doctors/yasui_hiroshi.html

Research field (5)： Hematology and oncology , Tumor diagnostics and therapeutics , Pharmaceuticals - chemistry and drug development , Molecular biology , Genomics

Research keywords (10)： hematology/oncology , oncology , internal medicine , Multiple Myeloma , Translational Research , Cancer Immunology , Investigator initiated trial under IND , 臨床試験 , Genomic Medicine , Artificial Intelligence

Research theme for competitive and other funds (13)：

2022 - 2028 Platform of Supporting Cohort Study and Biospecimen Analysis
2020 - 2023 Strategy to overcome the refractoriness of hematological malignancies through inhibition of intracellular signaling and immune enhancement
2016 - 2021 Platform of Supporting Cohort Study and Biospecimen Analysis
2014 - 2016 A fundamental study to develop novel targeted drug delivery systems for multiple myeloma therapy
2010 - 2016 Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

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Papers (95)：

Wei Yan, Xue Shi, Yun Zhao, Xiaoyu Liu, Xueming Jia, Le Gao, Jiahe Yuan, Aijun Liao, Hiroshi Yasui, Xiaobin Wang, et al. Microbiota-reprogrammed phosphatidylcholine inactivates cytotoxic CD8 T cells through UFMylation via exosomal SerpinB9 in multiple myeloma. Nature communications. 2025. 16. 1. 2863-2863
Naoki Osada, Jiro Kikuchi, Sae Matsuoka, Hiroshi Yasui, Sho Ikeda, Naoto Takahashi, Yusuke Furukawa, Hideki Nakasone. c-FOS Confers Stem Cell-like Features to Multiple Myeloma Cells in a Bone Marrow Microenvironment. Cells. 2025
Sae Matsuoka, Naoki Osada, Hirokazu Kubota, Ko Kikuzato, Hiroo Koyama, Takeshi Sonoda, Akiko Idei, Minoru Yoshida, Masaki Kikuchi, Takashi Umehara, et al. Discovery of a novel class NSD2 inhibitor for t(4;14)-positive multiple myeloma. Blood Neoplasia. 2025. 100091-100091
Hiroko Yaegashi, Yukikazu Hayashi, Makoto Takeda, Shih-Wei Chiu, Haruhiko Nakayama, Hiroyuki Ito, Atsushi Takano, Masahiro Tsuboi, Koji Teramoto, Hiroyuki Suzuki, et al. Efficiency of eSource Direct Data Capture in Investigator-Initiated Clinical Trials in Oncology. Therapeutic innovation & regulatory science. 2024
Jiro Kikuchi, Mitsuo Hori, Naoki Osada, Sae Matsuoka, Atsushi Suzuki, Satoshi Kakugawa, Hiroshi Yasui, Takeshi Harada, Hirofumi Tenshin, Masahiro Abe, et al. Soluble SLAMF7 is generated by alternative splicing in multiple myeloma cells. Haematologica. 2024. 109. 10. 3414-3418

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MISC (328)：

安井寛, 渡邉俊樹. 【学術研究支援の最先端】コホート・生体試料支援プラットフォーム(CoBiA) 生体試料支援 HTLV-1バイオリソースの収集と提供支援. 生体の科学. 2024. 75. 5. 504-505
長田直希, 松岡紗恵, 池田翔, 高橋直人, 安井寛, 古川雄祐, 菊池次郎, 仲宗根秀樹. LINC00887はHDAC3との結合を介して多発性骨髄腫細胞の薬剤耐性を誘導する. 日本血液学会学術集会. 2024. 86回. O1-1
菊池次郎, 長田直希, 松岡紗恵, 太田智美, 増田喬子, 風間啓敬, 白井丙五郎, Meloni Marco, Chiron Marielle, 安井寛, et al. 1q増幅陽性骨髄腫細胞においてFOXM1はイサツキシマブによる直接的細胞死の標的分子である. 日本血液学会学術集会. 2024. 86回. O1-2
松岡紗恵, 長田直希, 池田翔, 高橋直人, 安井寛, 古川雄祐, 菊池次郎, 仲宗根秀樹. SETD7はt(11;14)陽性多発性骨髄腫に対する新たな治療標的分子となる. 日本血液学会学術集会. 2024. 86回. O1-4
石垣知寛, 平野啓二, 土岐典子, 柳田匡俊, 安井寛. 分子イメージングサイトメトリーを用いたCAR-T細胞の免疫反応性評価法の確立. 日本血液学会学術集会. 2024. 86回. O1-1

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Books (8)：

ライフライン21 がんの先進医療別冊免疫力が変えるがんの治療・再発予防効果: 次世代がん治療として世界が注目する免疫療法について、専門家16人が語る最新ガイド
株式会社蕗書房 2015
造血器腫瘍とエピジェティクス-治療への応用と新たな展開-
医薬ジャーナル社 2012
原発性マクログロブリン血症の診断と治療
多発性骨髄腫診療ハンドブック(中外医学社) 2008
プロテアソーム阻害剤ボルテゾミブの臨床応用
蛋白質核酸酵素増刊号「ユビキチンープロテアソーム系とオートファジー」 (共立出版) 2006
Inhibition of TGF-β signaling in multiple myeloma and its bone marrow microenvironment [Review]
Transforming growth factor-beta in cancer therapy: Methods in Molecular Biology 2006

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Lectures and oral presentations (33)：

多発性骨髄腫における新規治療薬の有効性と有害事象-日欧米比較研究からの検討-
(第62回日本体質医学会総会 2012)
Study of FLC and PIC in immunoglobulin light chain amyloidosis
(The 74th Annual Meeting of the Japanese Society of Hematology 2012)
A model of Translational Cancer Research in Multiple Myeloma
(71st Annual Meeting of Japanese Cancer Association 2012)
多発性骨髄腫における基礎研究の進歩と臨床応用
(第54回日本血液学会秋季北海道地方会 2012)
北海道地域におけるHIV感染症の現況と対策
(第3回日本プライマリ・ケア連合学会学術大会 2012)

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Education (2)：

2000 - 2004 Graduate School of Medicine, Sapporo Medical University
1993 - 1999 Sapporo Medical University School of Medicine

Professional career (2)：

Ph.D. (Sapporo Medical University)
M.D. (Sapporo Medical University)

Work history (19)：

2024/06 - 現在 Kawasaki Municipal Tama Hospital Development of Hematology A part-time physician
2024/04 - 現在 St. Marianna University School of Medicine Department of Hematology and Oncology Specially Appointed Professor
2024/04 - 現在 The University of Tokyo Division of Cell Signaling and Molecular Medicine, The Institute of Medical Science Visiting Associate Professor
2024/04 - 現在 The University of Tokyo The Institute of Medical Science Research Hospital, Department of Hematology/Oncology Guest senior assistant professor
2018/07 - 現在 Mitsui Memorial Hospital, Tokyo Department of Hematology Visiting Physician

2023/06 - 2024/03 St.Marianna University School of Medicine Division of Hematology and Oncology, Department of Internal Medicine Part-time Lecturer

2023/04 - 2024/03 The University of Tokyo Project Division of Innovative Diagnostics Technology Platform, and Department of Hematology/Oncology of IMSUT hospital, The Institute of Medical Science Project Associate Professor

2022/10 - 2023/03 The University of Tokyo The Institute of Medical Science A part-time lecturer

2022/10 - 2023/03 St.Marianna University School of Medicine Division of Hematology & Oncology, Department of Internal Medicine Specially appointed Associate Professor

2021/10 - 2022/09 The University of Tokyo Project Division of Innovative Diagnostics Technology Platform, Research hospital / Department of Hematology/Oncology, The Institute of Medical Science Project associate professor and Chief of division

2016/01 - 2021/09 The University of Tokyo The Institute of Medical Science, Project Division of Fundamental Study on Cutting Edge of Genome Medicine / Research Hospital, Department of Hematology/Oncology Associate Professor (Project)

2013/01 - 2015/12 The University of Tokyo Center for Antibody and Vaccine Therapy, Research Hospital, The Institute of Medical Science Senior Assistant Professor (Project)

2011/03 - 2012/12 Sapporo Medical University First Department of Internal Medicine and Department of Regional Health Care and Medicine Instructor

2010/02 - 2011/02 Sapporo Medical University Department of Biochemistry, First Department of Internal Medicine Instructor

2006/10 - 2010/01 First Department of Internal Medicine Research and Clinical Fellow

2004/04 - 2006/09 Dana-Farber Cancer Institute, Harvard Medical School Jerome Lipper Multiple Myeloma Center (Prof. Kenneth Anderson) Postdoctoral Fellow

2002/04 - 2004/03 Japan Society for Promotion of Science Research Fellowships for Young Scientists

2000/04 - 2004/03 Graduate School of Medicine, Sapporo Medical University First Department of Internal Medicine Ph.D course

1999/04 - 2000/03 Sapporo Medical University Hospital First Department of Internal Medicine Resident of Medicine

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Committee career (9)：

2020/09 - 現在 Japanese Society of Myeloma Committee member (publicity, education, review, home page)
2018/04 - 現在 Japanese Electrophoresis Society Director
2016/04 - 現在 Japanese Electrophoresis Society Editorial board, Board of education
2015/10 - 現在 Japan Society for Moleculer Tumor Marker Research Delegate
2015/01 - 現在 The Japanese Cancer Association Councilor

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Awards (7)：

2025/03 - Korean Society of Hematology Travel Award (Blue Dragon) Clinical Features and Prognostic Factors of Adult Systemic Chronic Active Epstein-Barr Virus Disease: A Retrospective Analysis Using Japanese Registry Data
2024/03 - Korean Society of Hematology Special Travel award Immune function of chimeric antigen receptor T cells quantitatively assessed via molecular imaging flow cytometry
2024/03 - Korean Society of Hematology Best oral presentation award Immune function of chimeric antigen receptor T cells quantitatively assessed via molecular imaging flow cytometry
2019/07 - Japanese Electrophoresis Society Kodama Prize Electrophoresis for advanced clinical medicine of hematologic malignancies
2012/06 - Japan Society of Hematology 17th EHA Congress Travel Award for JSH Young Hematologists

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Association Membership(s) (18)：

The Japanese Association of Pharmaceutical Medicine , SOCIETY FOR REGULATORY SCIENCE OF MEDICAL PRODUCTS , JAPAN PRIMARY CARE ASSOCIATION , Japan Society for Moleculer Tumor Marker Reseach , THE JAPAN SOCIETY OF HUMAN GENETICS , Japan Society of Clinical Trials and Research , Japanese Association of Cancer Immunology , The Japan Society for Transplantation and Cellular Therapy , The Japanese Society of HTLV-1 and Associated Diseases , THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , JAPANESE ELECTROPHORESIS SOCIETY , The Japanese Society for AIDS Research , Japan Society of Myeloma , Japanese Cancer Association , The Japanese Society of Hematology , American Society of Hematology , THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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