Ogura Hiroshi

2023 - 2026 Development of a new method for evaluating gut microbiota that can be evaluated in a simple, low-cost, and short time

2022 - 2025 Analysis of gut barrier function and immunity via gut microbiota and establishment of gut microbiota reconstruction therapy in critically ill condition

2022 - 2025 網羅的生体分子情報に基づく重症熱傷病態の中心的分子解明と新規治療薬開発

2022 - 2025 Immunomolecular pathogenesis of systemic and local lung immunity in ARDS based on integrated analysis

2022 - 2025 脂肪細胞による全身性炎症反応制御:オートファジーとアディポカイン産生

2022 - 2025 網羅的分子生体情報を用いた頭部外傷患者に対する新たな治療戦略の構築

2021 - 2024 neuroprotective effects after traumatic brain injury by enteric hydrogen generation from Si-based agent

2021 - 2024 シングル細胞シークエンスを用いた敗血症における免疫抑制病態の解明と新規治療法開発

2021 - 2024 トランスクリプトームを用いた心停止の分子ネットワーク病態の解明と神経予後予測

2021 - 2024 ナノポア技術と機械学習を用いた新たな微生物迅速診断検査系の確立

2020 - 2023 The association between gut microbiome and host immunity focused on regulatory T cell in patients with critical illness

2020 - 2023 敗血症の炎症最適化のためのマーカーと分子病態分類の解明:HIVEP1の臨床応用

2020 - 2023 Profiling of circulating micro RNA expression in patients with sepsis

2021 - 2023 Development and clinical application of novel biomarkers of molecular pathogenesis using comprehensive gene/protein expression analysis in patients with novel coronavirus infection (COVID-19)

2019 - 2022 Trauma-specific memory-like regulatory T-cell responses and fundamental research for clinical translation

2019 - 2022 New developments in regenerative therapy for critical illness: the role of novel inflammatory amplification mechanisms.

2019 - 2022 重症病態での腸内細菌叢を介した免疫システム解明と腸内細菌叢再構築のための治療戦略

2019 - 2022 重症熱傷におけるグリコカリックスからみた血管内皮障害メカニズム解明と制御法の確立

2017 - 2022 Reconsideration of active therapeutics of septic enephalopathy by non-invasive methods focusing on molecular mechanism

2018 - 2021 Myeloid-derived suppressor cells infiltrate the brain and suppress neuroinflammation in a mouse model of focal traumatic brain injury

2017 - 2020 Randomized controlled trial of the effect of low carbohydrate and high fat diet on blood glucose variation in critically ill patients

2016 - 2020 A novel approach for diagnosis of meningitis and encephalitis using metagenomic sequencing

2016 - 2019 A novel development of regenerative therapy following acute systemic inflammatory response syndrome: the effects of transplantation of bone marrow-derived mononuclear cells and new rejuvenation factor

2016 - 2019 Citrullinated histon H3 for control of ciritical illness

2016 - 2019 Elucidation of mechanisms between endothelial injury and host immune response in severe trauma patients

2016 - 2019 Explanatory research of consciousness related substances in iPS cell-derived brain microvascular endothelial cell models

2015 - 2018 elucidation of the brain circulation during prehospital resuscitation

2015 - 2018 Establishment of methods for immune response analysis of lymphocytes and neutrophils against sepsis and trauma

2015 - 2018 A novel strategy for organ dysfunctions following systemic inflammatory response syndrome: the effect of new rejuvenation factor GDF11

2014 - 2017 The analysis of the gut microbiota change in severe emergency patients via high-throughput DNA sequencing

2013 - 2017 New strategy for critically ill patients by control of NETs

2013 - 2016 Regenerative therapy following severe insults: Establishment of cell transplantation and elucidation of immunologic response

2012 - 2015 Elucidation of the brain circulation during resuscitation.

2012 - 2015 A novel strategy for heat stroke: targeted therapy for free nucleotides

2012 - 2015 Establishment of synbiotic therapy in severe sepsis

2012 - 2014 Development of a novel strategy for heatstroke via the cholinergic anti-inflammatory pathway

2010 - 2014 The development of cell transplantation therapy against sepsis-associated multiple organ dysfunction targeted at endogenous stem cell function.

2010 - 2013 Regenerative therapy following severe insults : Establishment of cell transplantation in the blood

2010 - 2013 侵襲期低栄養患者に関するリスク評価及び病態解析

2009 - 2011 The effects of"Preemptive Infection Control" in critical care center

2009 - 2011 A novel strategy for heat stroke: Transplantation of mesenchymal stem cells

2007 - 2009 Regenerative response to insults : a novel strategy based on endothelial regeneration

2007 - 2009 Pathophysiological analysis for patients with anoxic coma after cardiopulmonary arrest.

2007 - 2009 Activation of endogenous neural stem cells using choroid plexus epithelial cells aimed at a new therapy for central nervous system injury

2006 - 2008 白血球のアクアポリンを介した全身性炎症反応の制御に関する研究

2006 - 2007 クラッシュ症候群における病態と治療に関する研究

2005 - 2007 The study on new artificial red blood cells (encapsulation Hb) at the shock

2005 - 2007 Gut flora and synbiotics therapy in patients with severe SIRS

2004 - 2006 Mechanisms of organ failure and abnormal oxygen metabolism during sepsis

2004 - 2006 ラット肺微少循環機能のリアルタイム計測技術の開発と応用

2003 - 2005 Immune response to severe insults: reaction through Toll-like receptors

2003 - 2005 Research on physiological responses in the acute phase of anoxic coma patients

2002 - 2004 Stress responses and leukocyte functions in sepsis

2001 - 2003 Telemedical support of emergency medicine using real-time telecommunication system.

2001 - 2003 脳死後の肺障害発生機序の解明と肺機能温存法開発に関する研究

2000 - 2002 Platelet-microparticles as a carrier of chemical mediators inducing remote organ failure

2000 - 2002 生体顕微鏡を用いた肺微小循環の可視化解析に関する研究

1999 - 2001 Investigation of the mechanism in multiple organ failure and the new approach by regulating leukocyte function

1998 - 2000 Elucidation of the mechanisms of cross-talk between the neurological, endocrine, and immune systems in the biological response to physical insults

1998 - 1999 侵襲時の多核白血球(PMNL)機能に関する総括的研究