Miyairi Shinichi

ミヤイリシンイチ | Miyairi Shinichi

Affiliation and department：
Job title： Professor

Research field (4)： Pharmaceuticals - analytical and physicochemistry , Pharmaceuticals - health and biochemistry , Pharmaceuticals - chemistry and drug development , Pharmaceuticals - chemistry and drug development

Research keywords (10)： Indirubin and its related compounds , Indole derivatives , Aryl hydrocarbon receptor , Enzyme-linked immunosorbent assay , autoinducer , Quorum sensing , Pseudomonas aeruginosa , Enzyme induction , Arylhydrocarbon receptor , Environmental pollutant

Papers (73)：

Toru Tanaka, Sachiyo Ohashi, Hiroaki Saito, Taira Wada, Tadashi Aoyama, Yoshimi Ichimaru, Shinichi Miyairi, Shunsuke Kobayashi. Indirubin 3′-oxime inhibits anticancer agent-induced YB-1 nuclear translocation in HepG2 human hepatocellular carcinoma cells. Biochemical and Biophysical Research Communications. 2018. 496. 1. 7-11
Yasuhiro Kosuge, Hiroaki Saito, Tatsuki Haraguchi, Yoshimi Ichimaru, Sachiyo Ohashi, Hiroko Miyagishi, Shunsuke Kobayashi, Kumiko Ishige, Shinichi Miyairi, Yoshihisa Ito. Indirubin derivatives protect against endoplasmic reticulum stress-induced cytotoxicity and down-regulate CHOP levels in HT22 cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017. 27. 23. 5122-5125
Yoshimi Ichimaru, Takeshi Fujii, Hiroaki Saito, Makoto Sano, Taketo Uchiyama, Shinichi Miyairi. 5-Bromoindirubin 3 '-(O-oxiran-2-ylmethyl)oxime: A long-acting anticancer agent and a suicide inhibitor for epoxide hydrolase. BIOORGANIC & MEDICINAL CHEMISTRY. 2017. 25. 17. 4665-4676
Makoto Sano, Yoshimi Ichimaru, Masahiro Kurita, Emiko Hayashi, Taku Homma, Hiroaki Saito, Shinobu Masuda, Norimichi Nemoto, Akihiro Hemmi, Takashi Suzuki, et al. Induction of cell death in pancreatic ductal adenocarcinoma by indirubin 3 '-oxime and 5-methoxyindirubin 3 '-oxime in vitro and in vivo. CANCER LETTERS. 2017. 397. 72-82
Emi Kanno, Kazuyoshi Kawakami, Shinichi Miyairi, Hiromasa Tanno, Aiko Suzuki, Rina Kamimatsuno, Naoyuki Takagi, Tomomitsu Miyasaka, Keiko Ishii, Naomasa Gotoh, et al. Promotion of acute-phase skin wound healing by Pseudomonas aeruginosa C-4-HSL. INTERNATIONAL WOUND JOURNAL. 2016. 13. 6. 1325-1335

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MISC (6)：

Yoshimi Ichimaru, Hiroaki Saito, Shinichi Miyairi. Is an inhibitor or blocker of inactivation of glycogen synthase kinase-3beta (GSK-3beta) a reliable agent for cancer chemotherapy?. International Journal of Clinical Pharmacology & Pharmacotherapy. 2016. 1. 102
Hiroaki Saito, Shinichi Miyairi. Recent Advances in Cinchona Alkaloid Catalysis for Enantioselective Carbon-Nitrogen Bond Formation Reactions. CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2014. 14. 2. 224-228
宮入伸一. Quorum-sensing制御による感染症治療の可能性. 分子呼吸器病. 2005. 9. 1. 33-37
宮入伸一, 南原利夫. 生物学的親和性を利用する分析法ー総論ー. ぶんせき. 1991. 9. 668-674
宮入伸一. アロマターゼインヒビター. ファルマシア. 1990. 26. 6. 558-561

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Patents (1)：

Indirubin derivative having highly selective cytotoxicity for malignant tumors

Books (13)：

薬がわかる構造式集
廣川書店 2013 ISBN:9784567462600
岩波生物学辞典第5版
岩波書店 2013 ISBN:9784000803144
イラストで見る化学実験の基礎知識第3版
丸善株式会社 2009 ISBN:4621080881
Indirubin, the red shade of indigo
2006 Life in Progress editions 2006 ISBN:2951802900
日本薬学会編知っておきたい有機反応100
東京化学同人 2006

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Lectures and oral presentations (119)：

浸潤性膵管癌の自然発症モデルマウスに対するインディルビン誘導体の治療効果の検証
(第64回日本薬学会東海支部大会 2018)
カルベノイドの高エナンチオ選択的N-H 挿入反応を目指したロジウム(II)錯体触媒の合成と機能評価
(日本薬学会第138年会 2018)
Tellimagrandin I アナログの合成とα-グルコシダーゼ阻害活性評価
(日本薬学会第138年会 2018)
インディルビン 3'-オキシム類の脂肪蓄積抑制効果
(日本薬学会第138年会 2018)
インディルビン誘導体の小胞体ストレス誘発細胞死に対する保護効果
(日本薬学会第138年会 2018)

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Education (3)：

1979 - 1982 Tohoku University Graduate School of Pharmaceutical Sciences
1977 - 1979 Tohoku University Graduate School of Pharmacetical Sciences
1972 - 1976 Science University of Tokyo Faculty of Pharmaceutical Science 製薬学科

Professional career (2)：

薬学修士 (東北大学)
薬学博士 (東北大学)

Work history (9)：

1993/04 - 2006/03 東北大学医学部非常勤講師
2001/04 - Nihon Univetsity School of Pharmacy Professor
1999/04 - 2001/03 Tohoku University Graduate School Graduate School of Pharmacetical Sciences Associate Professor
1993/07 - 1999/03 Tohoku University Associate Professor 助教授
1993/04 - 1994/03 東北大学医療短期大学部非常勤講師

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Association Membership(s) (8)：

日本薬学会 , 日本分析化学会 , 日本癌学会 , 日本臨床化学会 , 内分泌学会(The Endocrine Society) , 米国科学振興協会(American Association for the Advancement of Science) , 日本生化学会 , 日本内分泌撹乱物質学会

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