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J-GLOBAL ID：200902200926366727   Reference number：06A0705191

Association between the Severity of Hashimoto’s Disease and the Functional +874A/T Polymorphism in the Interferon-γ Gene

橋本病の重度とインターフェロン-γ遺伝子の機能的+874A/T多型との関連性

Author (5)： ITO Chisato (Dep. of Biomedical Informatics, Div. of Health Sci., Osaka Univ. Graduate School of Medicine) ,  WATANABE Mikio (Dep. of Biomedical Informatics, Div. of Health Sci., Osaka Univ. Graduate School of Medicine) ,  OKUDA Noriko (Dep. of Biomedical Informatics, Div. of Health Sci., Osaka Univ. Graduate School of Medicine) ,  WATANABE Chikami (Dep. of Biomedical Informatics, Div. of Health Sci., Osaka Univ. Graduate School of Medicine) ,  IWATANI Yoshinori (Dep. of Biomedical Informatics, Div. of Health Sci., Osaka Univ. Graduate School of Medicine)
Material： Endocrine Journal  (Endocr J)
Volume： 53  Issue： 4  Page： 473-478 (J-STAGE)  Publication year： 2006 
JST Material Number： F0625A  ISSN： 0918-8959  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： interferon gamma ,...
Semi thesaurus term： *Graves' Disease ,...

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JST classification (3)： Endocrine diseases  (GL03000I) ,  Cytokines  (EB08090G) ,  Molecular genetics in general  (EC02010J)

Reference (23)：

• 1. Volpe R (2001) The immune system and its role in endocrine function. In: Becker KL (ed) Principles and practice of endocrinology and metabolism. Lippincott Williams & Wilkins, Philadelphia: 1770-1781.
• 2. Davies TF (2000) Pathogenesis of Graves' disease. In: Braverman LE and Utiger RD (eds) The thyroid: a Fundamental and Clinical Text. Lippincott Williams & Wilkins, Philadelphia: 518-531.
• 3. Watanabe M, Yamamoto N, Maruoka H, Tamai H, Matsuzuka F, Miyauchi A, Iwatani Y (2002) Independent involvement of CD8⁺CD25⁺ cells and autoantibodies in disease severity of Hashimoto's disease. Thyroid 12: 801-808.
• 4. Iwatani Y, Watanabe M (1999) Normal mechanisms for self-tolerance. In: Volpe R (ed) Autoimmune endocrinopathies. Humana Press, Inc., Totawa: 1-30.
• 5. Pravica V, Perrey C, Stevens A, Lee JH, Hutchinson IV (2000) A single nucleotide polymorphism in the first intron of the human IFN-γ gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-γ production. Hum Immunol 61: 863-866.

Terms in the title (5)： 橋本病 ,  インターフェロン-γ ,  遺伝子 ,  多型 ,  関連性