Art

J-GLOBAL ID：200902268641312236   Reference number：08A1275123

New diterpene pyrone-type compounds, metarhizins A and B, isolated from entomopathogenic fungus, Metarhizium flavoviride and their inhibitory effects on cellular proliferation

昆虫病原菌,Metarhizium flavovirideから単離した新しいジテルペンであるピロン型化合物,メタリジンA及びB並びにその細胞増殖阻害効果

Author (11)： KIKUCHI Haruhisa (Graduate School of Pharmaceutical Sciences, Tohoku Univ., Aoba-yama, Aoba-ku, Sendai 980-8578, JPN) ,  HOSHI Tomoko (Graduate School of Pharmaceutical Sciences, Tohoku Univ., Aoba-yama, Aoba-ku, Sendai 980-8578, JPN) ,  KITAYAMA Minoru (Graduate School of Pharmaceutical Sciences, Tohoku Univ., Aoba-yama, Aoba-ku, Sendai 980-8578, JPN) ,  SEKIYA Mizuki (Graduate School of Pharmaceutical Sciences, Tohoku Univ., Aoba-yama, Aoba-ku, Sendai 980-8578, JPN) ,  KATOU Yasuhiro (Graduate School of Pharmaceutical Sciences, Tohoku Univ., Aoba-yama, Aoba-ku, Sendai 980-8578, JPN) ,  UEDA Kazunori (Graduate School of Pharmaceutical Sciences, Tohoku Univ., Aoba-yama, Aoba-ku, Sendai 980-8578, JPN) ,  KUBOHARA Yuzuru (Inst. for Molecular and Cellular Regulation, Gunma Univ., Maebashi 371-8512, JPN) ,  SATO Hiroki (Kyushu Res. Center, Forestry and Forest Products Res. Inst. Kurokami, Kumamoto 860-0862, JPN) ,  SHIMAZU Mitsuaki (Dep. of Forest Entomology, Forestry and Forest Products Res. Inst., 1 Matsunosato, Tsukuba, Ibaraki 305-8687 Japan) ,  KURATA Shoichiro (Graduate School of Pharmaceutical Sciences, Tohoku Univ., Aoba-yama, Aoba-ku, Sendai 980-8578, JPN) ,  OSHIMA Yoshiteru (Graduate School of Pharmaceutical Sciences, Tohoku Univ., Aoba-yama, Aoba-ku, Sendai 980-8578, JPN)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 65  Issue： 2  Page： 469-477  Publication year： Jan. 10, 2009 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *bicyclic diterpene ,  insect disease ,  *fungus ,  secondary metabolite ,  molecular structure ,  electron impact ionization mass spectrometry ,  proton magnetic resonance ,  13C NMR ,  two-dimensional NMR ,  *inhibition of multiplication ,  tumor cell ,  chemical synthesis ,  cell cycle ,  aliphatic alcohol
Semi thesaurus term： Metarhizium flavoviride

JST classification (2)： Diterpenes,sesterterpenes  (CF10023R) ,  Microorganism biochemistry  (EG03020N)

Substance index (13)： Methanol ,  MF-1 ,  Metarhizin B ,  Viridoxin A ,  (2R,3S)-2-Hydroxy-3-methylvaleric acid (1S,8aα)-1,4aβ-dimethyl-6-methylene-1α-(4-methyl-3-pentenyl)-5α-(2-oxo-4-methoxy-5,6-dimethyl-2H-pyran-3-ylmethyl)decalin-2β-yl ester ,  3-[[(1R,4aα)-2-Methylene-5α-(4-methyl-3-pentenyl)-5,8aβ-dimethyl-6β-hydroxydecalin-1α-yl]methyl]-4-(methoxymethoxy)-5,6-dimethyl-2H-pyran-2-one ,  Acetic acid (1S,8aα)-1,4aβ-dimethyl-6-methylene-1α-(4-methyl-3-pentenyl)-5α-[2-oxo-4-(methoxymethoxy)-5,6-dimethyl-2H-pyran-3-ylmethyl]decalin-2β-yl ester ,  Hexanoic acid (1S,8aα)-1,4aβ-dimethyl-6-methylene-1α-(4-methyl-3-pentenyl)-5α-[2-oxo-4-(methoxymethoxy)-5,6-dimethyl-2H-pyran-3-ylmethyl]decalin-2β-yl ester ,  Sesquicillin A ,  Hexanoic acid (1S,8aα)-1,4aβ-dimethyl-6-methylene-1α-(4-methyl-3-pentenyl)-5α-(2-oxo-4-hydroxy-5,6-dimethyl-2H-pyran-3-ylmethyl)decalin-2β-yl ester ,  Hexanoic acid (1S,8aα)-1,4aβ-dimethyl-6-methylene-1α-(4-methyl-3-pentenyl)-5α-(2-methoxy-4-oxo-5,6-dimethyl-4H-pyran-3-ylmethyl)decalin-2β-yl ester ,  Hexanoic acid (1S,8aα)-1,4aβ-dimethyl-6-methylene-1α-(4-methyl-3-pentenyl)-5α-(2-oxo-4-methoxy-5,6-dimethyl-2H-pyran-3-ylmethyl)decalin-2β-yl ester ,  (2R)-2-Hydroxyisovaleric acid (1S,8aα)-1,4aβ,6α-trimethyl-1α-(4-methyl-pentyl)-5α-(2-oxo-4-hydroxy-5,6-dimethyl-2H-pyran-3-ylmethyl)decalin-2β-yl ester

Terms in the title (7)： 昆虫病原菌 ,  Metarhizium ,  単離 ,  ジテルペン ,  ピロン ,  リジン ,  細胞増殖阻害効果