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J-GLOBAL ID：201502226813391926   Reference number：15A0314087

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

肝臓アセチルCoAは脂肪組織炎症を肝臓インスリン耐性およびII型糖尿病へつなぐ

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Author (26)： PERRY Rachel J. (Howard Hughes Medical Inst., Yale Univ., New Haven, CT 06519, USA) ,  PERRY Rachel J. (Dep. of Internal Medicine, Yale Univ., New Haven, CT 06520, USA) ,  PERRY Rachel J. (Dep. of Cellular and Molecular Physiology, Yale Univ., New Haven, CT 06520, USA) ,  CAMPOREZ Joao-Paulo G. (Dep. of Internal Medicine, Yale Univ., New Haven, CT 06520, USA) ,  KURSAWE Romy (Dep. of Internal Medicine, Yale Univ., New Haven, CT 06520, USA) ,  TITCHENELL Paul M. (The Inst. for Diabetes, Obesity and Metabolism, Perelman School of Medicine, Univ. of Pennsylvania, Philadelphia, PA ...) ,  ZHANG Dongyan (Howard Hughes Medical Inst., Yale Univ., New Haven, CT 06519, USA) ,  PERRY Curtis J. (Dep. of Immunobiology, Yale Univ., New Haven, CT 06520, USA) ,  JURCZAK Michael J. (Dep. of Internal Medicine, Yale Univ., New Haven, CT 06520, USA) ,  ABUDUKADIER Abulizi (Dep. of Internal Medicine, Yale Univ., New Haven, CT 06520, USA) ,  HAN Myoung Sook (Program in Molecular Medicine, Univ. of Massachusetts Medical School, Worcester, MA 01605, USA) ,  ZHANG Xian-Man (Howard Hughes Medical Inst., Yale Univ., New Haven, CT 06519, USA) ,  RUAN Hai-Bin (Dep. of Comparative Medicine, Yale Univ., New Haven, CT 06520, USA) ,  YANG Xiaoyong (Dep. of Cellular and Molecular Physiology, Yale Univ., New Haven, CT 06520, USA) ,  YANG Xiaoyong (Dep. of Comparative Medicine, Yale Univ., New Haven, CT 06520, USA) ,  CAPRIO Sonia (Dep. of Pediatrics, Yale Univ., New Haven, CT 06520, USA) ,  KAECH Susan M. (Dep. of Immunobiology, Yale Univ., New Haven, CT 06520, USA) ,  SUL Hei Sook (Dep. of Nutritional Sciences and Toxicology, Univ. of California, Berkeley, Berkeley, CA 94720, USA) ,  BIRNBAUM Morris J. (The Inst. for Diabetes, Obesity and Metabolism, Perelman School of Medicine, Univ. of Pennsylvania, Philadelphia, PA ...) ,  DAVIS Roger J. (Howard Hughes Medical Inst., Yale Univ., New Haven, CT 06519, USA) ,  DAVIS Roger J. (Program in Molecular Medicine, Univ. of Massachusetts Medical School, Worcester, MA 01605, USA) ,  CLINE Gary W. (Dep. of Internal Medicine, Yale Univ., New Haven, CT 06520, USA) ,  PETERSEN Kitt Falk (Dep. of Internal Medicine, Yale Univ., New Haven, CT 06520, USA) ,  SHULMAN Gerald I. (Howard Hughes Medical Inst., Yale Univ., New Haven, CT 06519, USA) ,  SHULMAN Gerald I. (Dep. of Internal Medicine, Yale Univ., New Haven, CT 06520, USA) ,  SHULMAN Gerald I. (Dep. of Cellular and Molecular Physiology, Yale Univ., New Haven, CT 06520, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 160  Issue： 4  Page： 745-758  Publication year： Feb. 12, 2015 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： knockout mouse ,  Rattus ,  liver ,  Adipose Tissue ,  *Lipid Metabolism ,  Inflammation ,  Insulin resistance ,  pathophysiology ,  Obesity ,  Type 2 diabetes mellitus ,  *gluconeogenesis ,  metabolic regulation ,  suppression and control ,  metabolite ,  acyl CoA ,  insulin signaling ,  Glucose repression ,  Adipose Tissue, White ,  Signal Transduction ,  Inflammation reaction ,  laboratory animal ,  Mus musculus ,  Myomorpha ,  Biliary Tract
Semi thesaurus term： cellular signal transduction ,  inflammatory response

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Animal metabolism and nutrition in general  (EJ02031R) ,  Biological function  (EB02020R)

Substance index (1)： Acetyl Coenzyme A

Terms in the title (5)： 肝臓 ,  アセチルCoA ,  脂肪組織炎症 ,  インスリン耐性 ,  II型糖尿病