Art

J-GLOBAL ID：201602251260843358   Reference number：16A1175912

Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignant mesothelioma and lung tumors

ラット肺内に気管内滴下した多層カーボンナノチューブは,肋膜悪性中皮腫と肺がんの発生を誘発する

Author (19)： Suzui Masumi (Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Futakuchi Mitsuru (Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Fukamachi Katsumi (Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Numano Takamasa (Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Abdelgied Mohamed (Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Abdelgied Mohamed (Nanotoxicology Project, Nagoya City University, Nagoya, Japan) ,  Abdelgied Mohamed (Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt) ,  Takahashi Satoru (Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Ohnishi Makoto (Japan Industrial Safety and Health Association, Japan Bioassay Research Center, Kanagawa, Japan) ,  Omori Toyonori (National Center for Child Health and Development, Tokyo, Japan) ,  Tsuruoka Shuji (Institute of Carbon Science and Technology, Shinshu University, Nagano City, Japan) ,  Hirose Akihiko (Division of Risk Assessment, National Institute of Health Sciences, Akihiko Hirose, Tokyo, Japan) ,  Kanno Jun (Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Tokyo, Japan) ,  Sakamoto Yoshimitsu (Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan) ,  Alexander David B. (Nanotoxicology Project, Nagoya City University, Nagoya, Japan) ,  Alexander William T. (Nanotoxicology Project, Nagoya City University, Nagoya, Japan) ,  Jiegou Xu (Nanotoxicology Project, Nagoya City University, Nagoya, Japan) ,  Jiegou Xu (Department of Immunology, College of Basic Medical Sciences, Anhui Medical University, Hefei, China) ,  Tsuda Hiroyuki (Nanotoxicology Project, Nagoya City University, Nagoya, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 107  Issue： 7  Page： 924-935  Publication year： 2016 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *multiwalled carbon nanotube ,...
Semi thesaurus term： *pleural mesothelioma ,...

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Author keywords (5)： Intratracheal instillation ,  lung tumors ,  malignant mesothelioma ,  multiwalled carbon nanotubes ,  rat

JST classification (3)： Carcinogenic mechanisms and factors  (GE02020C) ,  Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Medical materials  (GA05040H)

Reference (48)：

• Donaldson K, Poland CA. Nanotoxicology: new insights into nanotubes. Nat Nanotechnol 2009; 4: 708 - 10.
• Kohyama N, Suzuki Y. Analysis of asbestos fibers in lung parenchyma, pleural plaques, and mesothelioma tissues of North American insulation workers. Ann N Y Acad Sci 1991; 643:27-52.
• Donaldson K, Poland CA, Murphy FA, MacFarlane M, Chernova T, Schinwald A. Pulmonary toxicity of carbon nanotubes and asbestos - Similarities and differences. Adv Drug Deliv Rev 2013; 65: 2078-86.
• Takagi A, Hirose A, Nishimura T et al. Induction of mesothelioma in p53 + /- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 2008; 33: 105-16.
• Sakamoto Y, Nakae D, Fukumori N et al. Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J Toxicol Sci 2009; 34:65-76.

Terms in the title (9)： ラット ,  肺 ,  気管 ,  滴下 ,  多層カーボンナノチューブ ,  肋膜 ,  悪性中皮腫 ,  肺がん ,  誘発