Art

J-GLOBAL ID：201702239878357227   Reference number：17A1551610

RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity

RNAアプタマーは高い親和性と特異性でヘパリン結合表皮成長因子様成長因子を結合し,その活性を中和する【Powered by NICT】

Author (19)： Yamato Masaki (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Matsuzaki Takashi (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Araki Ryo (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Tsuchida Shota (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Okuda Keiji (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Fu Hai Ying (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Sanada Shoji (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Asanuma Hiroshi (Department of Internal Medicine, Meiji University of Integrative Medicine, Kyoto, Japan) ,  Asano Yoshihiro (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Asakura Masanori (Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan) ,  Torii Hiroomi (Graduate School of Engineering Science, Osaka University, Osaka, Japan) ,  Noi Kentaro (Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan) ,  Ogi Hirotsugu (Graduate School of Engineering Science, Osaka University, Osaka, Japan) ,  Iwamoto Ryo (Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan) ,  Mekada Eisuke (Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan) ,  Takashima Seiji (Department of Medical Biochemistry, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Kitakaze Masafumi (Department of Clinical Research and Development, National Cerebral and Cardiovascular Center, Osaka, Japan) ,  Sakata Yasushi (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Minamino Tetsuo (Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan)
Material： International Journal of Gerontology
Volume： 11  Issue： 3  Page： 191-196  Publication year： 2017 
JST Material Number： W3458A  ISSN： 1873-9598  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Heparin-binding epidermal grow...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A1551610&from=J-GLOBAL&jstjournalNo=W3458A") }}

Thesaurus term： phosphorylation ,  human ,  polymerase chain reaction ,  *EGF ,  oligonucleotide ,  Western blotting ,  *Heparin ,  *RNA ,  *affinity ,  EGF receptor ,  binding site ,  DNA ,  Ligands ,  HB-EGF ,  *aptamer ,  bioassay ,  *hematological drug ,  *anticoagulant ,  *drug ,  *glycoside ,  *polyuronide ,  *glucoside ,  *sugar sulfate ,  *drug acting on blood and body fluid

Author keywords (2)： aptamer ,  heparin-binding epidermal growth factor-like growth factor

JST classification (5)： Liver  (EJ06060J) ,  Cell physiology in general  (EF02010S) ,  Enzyme in general  (EB09010D) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Cytokines  (EB08090G)

Terms in the title (8)： RNAアプタマー ,  親和性 ,  特異性 ,  ヘパリン ,  表皮成長因子 ,  成長因子 ,  活性 ,  中和