Art

J-GLOBAL ID：201702241064678533   Reference number：17A0972341

Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder

双極性障害におけるミトコンドリアDNAポリメラーゼ遺伝子(POLG1)の有害変異のエンリッチメント

Author (21)： Kasahara Takaoki (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Ishiwata Mizuho (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Kakiuchi Chihiro (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Fuke Satoshi (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Iwata Nakao (Faculty of Medicine, Department of Psychiatry, Fujita Health University, Japan) ,  Ozaki Norio (Faculty of Medicine, Department of Psychiatry, Nagoya University, Nagoya, Japan) ,  Kunugi Hiroshi (Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Minabe Yoshio (Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Nakamura Kazuhiko (Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Iwata Yasuhide (Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Fujii Kumiko (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Fujii Kumiko (Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan) ,  Kanba Shigenobu (Department of Psychiatry, Kyushu University School of Medicine, Fukuoka, Japan) ,  Ujike Hiroshi (Department of Psychiatry, Okayama University School of Medicine, Okayama, Japan) ,  Kusumi Ichiro (Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan) ,  Kataoka Muneko (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Matoba Nana (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Takata Atsushi (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan) ,  Iwamoto Kazuya (Department of Molecular Brain Science, Graduate School of Medicine, Kumamoto University, Kumamoto, Japan) ,  Yoshikawa Takeo (Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan) ,  Kato Tadafumi (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan)
Material： Psychiatry and Clinical Neurosciences  (Psychiatry Clin Neurosci)
Volume： 71  Issue： 8  Page： 518-529  Publication year： Aug. 2017 
JST Material Number： W1032A  ISSN： 1323-1316  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *DNA polymerase ,...
Semi thesaurus term： *genetic variation ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A0972341&from=J-GLOBAL&jstjournalNo=W1032A") }}

Author keywords (5)： bipolar disorder ,  mitochondrial dysfunction ,  POLG ,  POLG1 ,  rare variants

JST classification (1)： Basic psychiatry  (GR01020I)

Reference (44)：

• Merikangas KR, Jin R, He JP et al. Prevalence and correlates of bipolar spectrum disorder in the World Mental Health Survey Initiative. Arch. Gen. Psychiatry 2011; 68: 241-251.
• Kawakami N. Large-scale epidemiological study on the prevalence of mental disorders: World Mental Health Japan Survey. A report of the Health Labour Sciences Research Grant from The Ministry of Health Labour and Welfare. 2014 (in Japanese).
• Kato T. Whole genome/exome sequencing in mood and psychotic disorders. Psychiatry Clin. Neurosci. 2015; 69: 65-76.
• Kerner B. Toward a deeper understanding of the genetics of bipolar disorder. Front. Psychiatry 2015; 6: 105.
• Chen DT, Jiang X, Akula N et al. Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Mol. Psychiatry 2013; 18: 195-205.

Terms in the title (5)： 双極性障害 ,  ミトコンドリア ,  DNAポリメラーゼ ,  遺伝子 ,  変異