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J-GLOBAL ID：201802261944677818   Reference number：18A2218818

Syntheses of prodrug-type 2′-O-methyldithiomethyl oligonucleotides modified at natural four nucleoside residues and their conversions into natural 2′-hydroxy oligonucleotides under reducing condition

天然4ヌクレオシド残基で修飾されたプロドラッグ型2′-O-メチルジチオメチルオリゴヌクレオチドの合成と還元条件下での天然2′-ヒドロキシオリゴヌクレオチドへの変換【JST・京大機械翻訳】

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Author (10)： Hayashi Junsuke (Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Ochi Yosuke (Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Morita Yasuyuki (Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Soubou Katsuma (Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Ohtomo Yuhei (Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Nishigaki Misa (Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Tochiyama Yuko (Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Nakagawa Osamu (Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Wada Shun-ichi (Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Urata Hidehito (Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 26  Issue： 22  Page： 5838-5844  Publication year： 2018 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We previously reported that re...

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Thesaurus term： precursor (substance) ,  siRNA ,  Cytoplasm ,  *nucleoside ,  RNA ,  nuclease ,  *prodrug ,  *oligonucleotide ,  *reduction (reaction) ,  Gene Knockdown Technique ,  pyrimidine nucleoside ,  ribonucleoside ,  purine nucleoside
Semi thesaurus term： 残基 , 【Automatic Indexing@JST】

Author keywords (4)： Prodrug-type RNA ,  Reducing environment ,  2′-O-modified RNA ,  Post-synthetic modification

JST classification (2)： Nucleic acids in general  (EB04010U) ,  Nucleosides,nucleotides  (CF10060K)

Substance index (4)： Cytidine ,  Guanosine ,  Adenosine ,  Uridine

Terms in the title (5)： ヌクレオシド ,  残基 ,  修飾 ,  プロドラッグ ,  還元