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J-GLOBAL ID：201802265112776433   Reference number：18A0130215

4-Methylthio-3-butenyl isothiocyanate mediates nuclear factor (erythroid-derived 2)-like 2 activation by regulating reactive oxygen species production in human esophageal epithelial cells

4-メチルチオ-3-ブテニルイソチオシアネートはヒト食道上皮細胞における活性酸素種の産生を調節することにより核因子(赤血球由来2) 様2活性化を仲介する【Powered by NICT】

Author (10)： Hirata Tadashi (Division of Pathology, National Institute of Health Sciences, Tokyo, Japan) ,  Hirata Tadashi (Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, Tokyo, Japan) ,  Cho Young-Man (Division of Pathology, National Institute of Health Sciences, Tokyo, Japan) ,  Suzuki Isamu (Division of Pathology, National Institute of Health Sciences, Tokyo, Japan) ,  Suzuki Isamu (Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan) ,  Toyoda Takeshi (Division of Pathology, National Institute of Health Sciences, Tokyo, Japan) ,  Akagi Jun-ichi (Division of Pathology, National Institute of Health Sciences, Tokyo, Japan) ,  Nakamura Yasushi (Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Kyoto, Japan) ,  Numazawa Satoshi (Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, Tokyo, Japan) ,  Ogawa Kumiko (Division of Pathology, National Institute of Health Sciences, Tokyo, Japan)
Material： Food and Chemical Toxicology  (Food Chem Toxicol)
Volume： 111  Page： 295-301  Publication year： 2018 
JST Material Number： B0937A  ISSN： 0278-6915  CODEN： FCTOD7  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： 4-Methylthio-3-butenyl isothio...

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Thesaurus term： gene ,  *epithelial cell ,  phosphorylation ,  carcinogenesis ,  carcinogen ,  ERK ,  *active oxygen ,  *esophagus ,  *erythrocyte ,  *human(primates) ,  Western blotting
Semi thesaurus term： キナーゼ ,  NFE2関連因子2 ,  細胞保護 ,  第II相酵素 , 【Automatic Indexing@JST】

Author keywords (5)： Chemoprevention ,  Isothiocyanate ,  4-Methylthio-3-butenyl isothiocyanate ,  Nuclear factor (erythroid-derived 2)-like 2 ,  Reactive oxygen species

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Cell physiology in general  (EF02010S)

Terms in the title (10)： ヒト ,  食道 ,  上皮細胞 ,  活性酸素種 ,  調節 ,  核 ,  因子 ,  赤血球 ,  活性化 ,  仲介