Yoshida Keisuke

ヨシダケイスケ | Yoshida Keisuke

Affiliation and department：
Job title： Associate Professor

Research field (2)： Genomics , Molecular biology

Research keywords (7)： Environmental stress-induced epigenetic change , Genome Editing , Spermatozoa , ATF7 , Transgenerational Inheritance , Pathogenic Variant , Epigenetics

Research theme for competitive and other funds (7)：

2020 - 2024 Study of environmental factor-induced diversity in disease phenotype
2018 - 2021 Analysis for sperm epigenome regulated by ATF7 using complete mature sperm
2016 - 2019 Molecular analysis of effect of infection stress into the next generation
2017 - 2019 Molecular mechanism for inheritance trait from parental hygiene environment
2011 - 2012 Transgenerational inheritance of altered gene expression via stress

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Papers (18)：

Takehiro Tozuka, Rintaro Noro, Keisuke Yoshida, Satoshi Takahashi, Mariko Hirao, Kuniko Matsuda, Yasuhiro Kato, Shinji Nakamichi, Susumu Takeuchi, Masaru Matsumoto, et al. Phosphoproteomic Analysis Identified Mutual Phosphorylation of FAK and Src as a Mechanism of Osimertinib Resistance in EGFR-Mutant Lung Cancer. JTO Clinical and Research Reports. 2024. 5. 4. 100668-100668
Keisuke Yoshida, Shin-Ichiro Fujita, Ayako Isotani, Takashi Kudo, Satoru Takahashi, Masahito Ikawa, Dai Shiba, Masaki Shirakawa, Masafumi Muratani, Shunsuke Ishii. Intergenerational effect of short-term spaceflight in mice. iScience. 2021. 24. 7. 102773-102773
Keisuke Yoshida, Toshio Maekawa, Nhung Hong Ly, Shin-ichiro Fujita, Masafumi Muratani, Minami Ando, Yuki Katou, Hiromitsu Araki, Fumihito Miura, Katsuhiko Shirahige, et al. ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet. Molecular Cell. 2020
Toshio Maekawa, Binbin Liu, Yang Liu, Keisuke Yoshida, Masafumi Muratani, Bruno Chatton, Shunsuke Ishii. Stress-induced and ATF7-dependent epigenetic change influences cellular senescence. Genes to cells. 2019. 24. 9. 627-635
Nhung Hong Ly, Toshio Maekawa, Keisuke Yoshida, Yang Liu, Masafumi Muratani, Shunsuke Ishii. RNA-Sequencing Analysis of Paternal Low-Protein Diet-Induced Gene Expression Change in Mouse Offspring Adipocytes. G3. 2019. 9. 7. 2161-2170

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Books (7)：

自然免疫記憶とエピゲノム変化
科学評論社 2021
父親の環境ストレスの遺伝
羊土社 2021
エピゲノム記憶によって誘導される訓練免疫
学会出版センター 2021 ISBN:476220837X
Transmission of epigenetic change
2020
Epigenome defined by outer environment
2016

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Lectures and oral presentations (25)：

Transgenerational inheritance of paternal environmental stress
(The 51st Annual Meeting of the Japanese Society of Toxicology 2024)
父親の炎症ストレスが子供の腎機能に与える影響
(第46回日本分子生物学会年会 2023)
Effect of paternal low-protein diet on oncogene expression in mouse mouse offspring
(The 43th Japan Society for Molecular Tumor Marker Research 2023)
宇宙マウスとその子供達のはなし
(日本遺伝学会第95回大会公開市民講座『宇宙環境と遺伝』 2023)
父親の環境ストレスの遺伝メカニズム
(環境ホルモン学会自由集会5「内分泌かく乱物質とエピジェネティクス」 2022)

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Education (2)：

2006 - 2010 Tokyo Tech Graduate School of Bioscience
2002 - 2006 Tokyo Tech School of Bioscience

Professional career (1)：

PhD (TiTech (Japan))

Work history (5)：

2021/10 - 現在 Nippon Medical School Department of Bioregulation Associate Professor
2019/04 - 2021/09 RIKEN, BRC Next Generation Human Disease Model Team R&D Researcher
2013/04 - 2019/03 RIKEN, tsukuba Molecular Genetics Lab. Cooperative Research Fellow
2010/04 - 2013/03 RIKEN, tsukuba Molecular Genetics Lab. Special Postdoctoral Researchers Program
2009/04 - 2010/03 Tokyo Institute of Technology Graduate School of Bioscience JSPS・DC2

Association Membership(s) (2)：

The Japanese Cancer Association , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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